Crisis of wild animal life viewed through genome analysis: P450 strategy to cope with environmental pollution

In addition to various artificial chemical substances, such as drugs, environmental chemicals and food additives, even naturally derived materials contained in food products become foreign substances for animals when incorporated into their bodies. All living beings, including humans, have mechanisms that eliminate xenobiotics before such substances produce toxic effects in their bodies. In the toxicology laboratory, we study detoxification mechanisms, such as cytochrome P450, that biological species have developed in adapting to the environment which is flooded with chemicals. We also conduct research on living organisms as well as their ecosystems to investigate how chemicals in natural fields produce toxic effects on humans and animals (the photo shows surveillance in an African country).


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