2024年
*Original articles
1）Ogawara K, Inanami O, Takakura H, Saita K, Nakajima K, Kumar S, Ieda N, Kobayashi M, Taketsugu T, Ogawa M
Theoretical Design and Synthesis of Caged Compounds Using X-Ray-Triggered Azo Bond Cleavage.
Adv Sci (Weinh). 11(12), e2306586, 2024.
doi: 10.1002/advs.202306586
2）Kato-Suzuki M, Okamatsu-Ogura Y, Inanami O, Kimura K.
Time-dependent changes in retinoids content in liver and adipose tissue after feeding of a vitamin A-deficient diet to mice.
Exp Anim. 73, 302-309, 2024.
doi: 10.1538/expanim.23-0123
3) Goto Y, Ando K, Takakura H, Nakajima K, Kobayashi M, Inanami O, Taketsugu T, Ogawa M.
Development of a red-shifted photosensitizer for near-infrared photoimmunotherapy of cancer.
J Photochem Photobiol. 20, 100230, 2024.
doi: 10.1016/j.jpap.2024.100230
4) Tada T, Mizuno Y, Shibata Y, Yasui H, Kuge Y.
Application of copper (I) selective ligands for PET imaging of reactive oxygen species through metabolic trapping.
Nucl Med Biol. 134-135, 108914, 2024
doi: 10.1016/j.nucmedbio.2024.108914
5) Kato K, Yasui H, Sato-Akaba H, Emoto MC, Fujii HG, Kmiec MM, Kuppusamy P, Mizuno Y, Kuge Y, Nagane M, Yamashita T, Inanami O.
Feasibility study of multimodal imaging for redox status and glucose metabolism in tumor.
Free Radic Biol Med. 218, 57-67, 2024.
doi: 10.1016/j.freeradbiomed.2024.03.028
6) Oba M, Taguchi M, Kudo Y, Yamashita K, Yasui H, Matsumoto S, Kirilyuk IA, Inanami O, Hirata H.
Partial Acquisition of Spectral Projections Accelerates Four-dimensional Spectral-spatial EPR Imaging for Mouse Tumor Models: A Feasibility Study.
Mol Imaging Biol. 26, 459-472, 2024.
doi: 10.1007/s11307-024-01924-y
7) Yamashita K, Yasui H, Bo T, Fujimoto M, Inanami O.
Mechanism of the Radioresistant Colorectal Cancer Cell Line SW480RR Established after Fractionated X Irradiation.
Radiat Res. 202, 38-50, 2024
doi: 10.1667/RADE-23-00021.1
8) Kitamura H, Fujimoto M, Hashimoto M, Yasui H, Inanami O.
USP2 Mitigates Reactive Oxygen Species-Induced Mitochondrial Damage via UCP2 Expression in Myoblasts.
Int J Mol Sci. 25, 11936, 2024.
doi: 10.3390/ijms252211936
9) Higashikawa K, Uehara R, Horiguchi S, Shibata Y, Okubo N, Mizuno Y, Yasui H, Ohnishi S, Takeda H, Kuge Y.
Thymidine Phosphorylase Imaging Probe for Differential Diagnosis of Metabolic dysfunction-associated Steatohepatitis.
Mol Imaging Biol. 26, 1036-1045, 2024
doi: 10.1007/s11307-024-01964-4
10) Yamaguchi M, Htun KT, Tatara Y, Sato Y, Hosoda M, Kothan S, Kamimura C, Inanami O, Kashiwakura I.
Radio-protective effects of ultra-fine bubble hydrogen water and serum protein responses in whole-body radiation-exposed mice.
Radiat Res. Sci Rep 15, 4447, 2025
doi: 10.1038/s41598-025-87963-z
11) Miyazono K, Tomihari M, Arashiki N, Koshino I, Otsuka-Yamasaki Y, Kizaki K, Tsukamoto T, Inanami O, Deguchi A, Kitaguchi E, Demura M, Mohandas N, Takakuwa Y, Inaba M.
Red cell shape regulation by band 3–ankyrin–spectrin linkage: Implications for clinical severity of bovine HS.
Blood Red Cells & Iron. 2025.
doi: 10.1016/j.brci.2025.100003
12) Ogawara K, Ieda N, Takakura H, Nakajima K, Mukaimine A, Harada M, Hashimoto K, Inanami O, Ogawa M.
Effect of hydroxy groups on X-ray-induced reactions of azo benzene derivatives.
Org Biomol Chem. 2025
doi: 10.1039/d5ob00003c
2023年
*Original articles
1）Nakajima K, Sugikawa A, Yasui H, Higashikawa K, Suzuki C, Natsume T, Suzuki M, Takakura H, Tomita M, Takahashi S, Hirata K, Magata Y, Kuge Y, Ogawa M.
In vivo imaging of acute physiological responses after treatment of cancer with near-infrared photoimmunotherapy.
Mol Imaging Biol. 25(4), 648-658, 2023.
doi: 10.1007/s11307-023-01822-9
*Other publications
1） 安井博宣, 小澤拓実, 藤本政毅, 稲波修. 老化細胞標的がん治療 -がんセノセラピー-に向けた基礎研究. Precision Medicine 6(13), 1096-1100, 2023
2022年
*Original articles
1）Fujimoto M, Higashiyama R, Yasui H, Yamashita K, Inanami O.
Preclinical studies for improving radiosensitivity of non-small cell lung cancer cell lines by combining glutaminase inhibition and senolysis.
Transl Oncol. 21, 101431, 2022.
doi: 10.1016/j.tranon.2022.101431
2) Hashimoto M, Fujimoto M, Konno K, Lee ML, Yamada Y, Yamashita K, Toda C, Tomura M, Watanabe M, Inanami O, Kitamura H.
Ubiquitin-specific protease 2 in the ventromedial hypothalamus modifies blood glucose levels by controlling sympathetic nervous activation.
J Neurosci. 42(23), 4607-4618, 2022.
doi: 10.1523/JNEUROSCI.2504-21.2022
3) Takakura H, Matsuhiro S, Inanami O, Kobayashi M, Saita K, Yamashita M, Nakajima K, Suzuki M, Miyamoto N, Taketsugu T, Ogawa M.
Ligand release from silicon phthalocyanine dyes triggered by X-ray irradiation.
Org Biomol Chem. 20(36), 7270-7277, 2022
doi: 10.1039/d2ob00957a
4) Kawai T, Matsuo M, Takakusagi Y, Saito K, Hyodo F, Devasahayam N, Matsumoto S, Kishimoto S, Yasui H, Yamamoto K, Krishna MC.
Continuous monitoring of postirradiation reoxygenation and cycling hypoxia using electron paramagnetic resonance imaging.
NMR Biomed. 35(10), e4783, 2022.
doi: 10.1002/nbm.4783
5) Takamiya S, Kawabori M, Kitahashi T, Nakamura K, Mizuno Y, Yasui H, Kuge Y, Tanimori A, Takamatsu Y, Yuyama K, Shichinohe H, Fujimura M.
Intracerebral transplantation of mesenchymal stromal cell compounded with recombinant peptide scaffold against chronic intracerebral hemorrhage model.
Stem Cells Int. 2022, 8521922, 2022.
doi: 10.1155/2022/8521922
6) Nakaoka R, Kato K, Yamamoto K, Yasui H, Matsumoto S, Kirilyuk IA, Khramtsov VV, Inanami O, Hirata H.
Electron paramagnetic resonance implemented with multiple harmonic detections successfully maps extracellular pH in vivo.
Anal Chem. 95(8), 3940-3950, 2022
doi: 10.1021/acs.analchem.2c03194
*Other publications
1） 安井博宣, 小澤拓実, 藤本政毅, 稲波修. 細胞老化の制御に基づく新しいがん治療戦略. 細胞 55(2), 115-118, 2023
2021年
*Original articles
1）Nagane M, Yasui H, Kuppusamy P, Yamashita T, Inanami O.
DNA damage response in vascular endothelial senescence: Implication for radiation-induced cardiovascular diseases.
J Radiat Res. 62(4), 564-573, 2021.
doi: 10.1093/jrr/rrab032
2) Gulay KCM, Aoshima K, Shibata Y, Yasui H, Yan Q, Kobayashi A, Kimura T.
Kdm2b promotes cell viability by enhancing DNA 1 damage response in canine hemangiosarcoma.
J Genet Genom. 48(7), 618-630, 2021.
doi: 10.1016/j.jgg.2021.02.005.
3) Deguchi T, Hosoya K, Kim S, Murase Y, Yamamoto K, Bo T, Yasui H, Inanami O, Okumura M.
Metformin preferentially enhances the radiosensitivity of cancer stem-like cells with highly mitochondrial respiration ability in canine osteosarcoma cell line.
Mol Ther Oncolytics. 22, 143-151, 2021
doi: 10.1016/j.omto.2021.08.007
4) Bo T, Kobayashi S, Inanami O, Fujii J, Nakajima O, Ito T, Yasui H.
LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence.
Transl Oncol. 14(11), 101212, 2021.
doi: 10.1016/j.tranon.2021.101212
5) Kato T, Okada R, Goto Y, Furusawa A, Inagaki F, Wakiyama H, Furumoto H, Daar D, Turkbey B, Choyke PL, Takakura H, Inanami O, Ogawa M, Kobayashi H.
Electron Donors Rather Than Reactive Oxygen Species Needed for Therapeutic Photochemical Reaction of Near-Infrared Photoimmunotherapy.
ACS Pharmacol Transl Sci. 4(5), 1689-1701, 2021.
doi: 10.1021/acsptsci.1c00184
6) Kimura K, Iguchi N, Nakano H, Yasui H, Matsumoto S, Inanami O, Hirata H.
Redox-sensitive mapping of a mouse tumor model using sparse projection sampling of electron paramagnetic resonance.
Antioxid Redox Signal. 36(1-3), 57-69, 2022
doi: 10.1089/ars.2021.0003
7) Bo T, Yasui H, Shiga T, Shibata Y, Fujimoto M, Suzuki M, Higashikawa K, Miyamoto N, Inanami O, Kuge Y.
Eribulin improves tumor oxygenation demonstrated by 18F-DiFA hypoxia imaging, leading to radio-sensitization in human cancer xenograft models.
Eur J Nucl Med Mol Imaging. 49(3), 821-833, 2022.
doi: 10.1007/s00259-021-05544-4
8) Inanami O, Hiraoka W, Goto Y, Takakura H, Ogawa M.
EPR Characterisation of Phthalocyanine Radical Anions in Near-Infrared Photocleavage of the Hydrophilic Axial Ligand of a Photoimmunotherapeutic Reagent, IR700.
ChemPhotoChem. 6(1), e202100172, 2022.
doi: 10.1002/cptc.202100172
*Other publications
1） 稲波修, 安井博宣. ナノ粒子による腫瘍細胞における放射線増感機構. 化学工業 72(4), 238-243, 2021
2） 藤本政毅, 安井博宣, 稲波修. グルタミン代謝阻害とセノリシスを組み合わせた新しい放射線治療の可能性. 細胞 53(12), :698-701, 2021
2020年
*Original articles
1）Higashikawa K, Horiguchi S, Tarisawa M, Shibata Y, Ohkura K, Yasui H, Takeda H, Kuge Y.
Preclinical investigation of potential use of thymidine phosphorylase-targeting tracer for diagnosis of nonalcoholic steatohepatitis.
Nucl Med Biol. 2020;82-83:25-32.
doi: 10.1016/j.nucmedbio.2019.12.006.
2) Yasui H, Iizuka D, Hiraoka W, Kuwabara M, Matsuda A, Inanami O.
Nucleoside analogs as a radiosensitizer modulating DNA repair, cell cycle checkpoints, and apoptosis.
Nucleosides, Nucleotides and Nucleic Acids. 2020;39(1-3):439-452.
doi: 10.1080/15257770.2019.1670839.
3) Bo T, Yamamori T, Yamamoto K, Fujimoto M, Yasui H, Inanami O.
Mitochondrial fission promotes radiation-induced increase in intracellular Ca2+ level leading to mitotic catastrophe in mouse breast cancer EMT6 cells.
Biochem Biophys Res Commun. 2020;522(1):144-150.
doi: 10.1016/j.bbrc.2019.11.027
4) Wang Z, Higashikawa K, Yasui H, Kuge Y, Ohno Y, Kihara A, Yenari M, Houkin K, Kawabori M.
FTY720 protects against ischemia–reperfusion injury by preventing the redistribution of tight junction proteins and decreases inflammation in the sub-acute phase in an experimental stroke model.
Transl Stroke Res. 2020;11(5):1103-1116.
doi: 10.1007/s12975-020-00789-x
5) Fujimoto M, Bo T, Yamamoto K, Yasui H, Yamamori T, Inanami O
Radiation-induced abnormal centrosome amplification and mitotic catastrophe in human cervical tumor HeLa cells and murine mammary tumor EMT6 cells.
J Clin Biochem Nutr. 2020;67(3):240-247.
doi: 10.3164/jcbn.19-80
6) Oiwa Y, Oka K, Yasui H, Higashikawa K, Bono H, Kawamura Y, Miyawaki S, Watarai A, Kikusui T, Shimizu A, Okano H, Kuge Y, Kimura K, Okamatsu-Ogura Y, Miura K.
Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal.
Sci Rep. 2020;10(1):19488.
doi: 10.1038/s41598-020-74929-6
*Other Publications
1） Yasui H, Matsumoto S, Inanami O, Krishna M.C.
Imaging of Tumor-Specific Hypoxia Dynamics and Its Significance in Radiation Biology.
Igaku Butsuri. 2020;40(1):13-18. (in Japanese)
2019年
*Original articles
1) Yoneshiro T, Shin W, Machida K, Fukano K, Tsubota A, Chen Y, Yasui H, Inanami O, Okamatsu-Ogura Y, Kimura, K.
Differentiation of bone marrow?derived cells toward thermogenic adipocytes in white adipose tissue induced by the β3 adrenergic stimulation.
FASEB J. 2019;33(4):5196-5207.
doi: 10.1096/fj.201801757RR.
2) Bhilwade HN, Tatewaki N, Konishi T, Nishida M, Eitsuka T, Yasui H, Inanami O, Handa O, Naito Y, Ikekawa N, Nishida, H..
The Adjuvant Effect of Squalene, an Active Ingredient of Functional Foods, on Doxorubicin-Treated Allograft Mice.
Nutr Cancer. 2019;10:1-12.
doi: 10.1080/01635581.2019.1597900.
3) Watanabe S, Shiga T, Hirata K, Magota K, Okamoto S, Toyonaga T, Higashikawa K, Yasui H, Kobayashi J, Nishijima KI, Iseki K, Matsumoto H, Kuge Y, Tamaki N.
Biodistribution and Radiation Dosimetry of the Novel Hypoxia PET Probe [18F]DiFA and comparison with [18F]FMISO.
EJNMMI Res. 2019;9(1):60.
doi: 10.1186/s13550-019-0525-6.
4) Morita A, Gulay KCM, Onishi S, Shibata Y, Yasui H, Kobayashi A, Kimura T.
High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines.
Res Vet Sci. 2019;127:1-10
doi: 10.1016/j.rvsc.2019.09.011.
5）Hashimoto M, Saito N, Ohta H, Yamamoto K, Tashiro A, Nakazawa K, Inanami O, Kitamura H.
Inhibition of ubiquitin-specific protease 2 causes accumulation of reactive oxygen species, mitochondria dysfunction, and intracellular ATP decrement in C2C12 myoblasts.
Physiol Rep. 2019;7(14):e14193.
doi: 10.14814/phy2.14193.
6）Bo T, Yamamori T, Yamamoto K, Fujimoto M, Yasui H, Inanami O.
Mitochondrial fission promotes radiation-induced increase in intracellular Ca2+ level leading to mitotic catastrophe in mouse breast cancer EMT6 cells.
Biochem Biophys Res Commun. 2019;522(1):144-150.
doi: 10.1016/j.bbrc.2019.11.027.
7）Shibata Y, Yasui H, Higashikawa K, Miyamoto N, Kuge Y.
Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo.
PLoS One. 2019;14(12):e0225931.
doi: 10.1371/journal.pone.0225931.
8）Shimizu Y, Zhao S, Yasui H, Nishijima KI, Matsumoto H, Shiga T, Tamaki N, Ogawa M, Kuge Y.
A Novel PET Probe "[18F]DiFA" Accumulates in Hypoxic Region via Glutathione Conjugation Following Reductive Metabolism.
Mol Imaging Biol. 2019;21(1):122-129.
doi: 10.1007/s11307-018-1214-y.
2018年
*Original articles
1) Bo T, Yamamori T, Suzuki M, Sakai Y, Yamamoto K, Inanami O.
Calmodulin-dependent protein kinase II (CaMKII) mediates radiation-induced mitochondrial fission by regulating the phosphorylation of dynamin-related protein 1 (Drp1) at serine 616.
Biochem Biophys Res Commun. 2018;495(2):1601-1607.
doi: 10.1016/j.bbrc.2017.12.012.
2) Sakai Y, Yamamori T, Yoshikawa Y, Bo T, Suzuki M, Yamamoto K, Ago T, Inanami O.
NADPH oxidase 4 mediates ROS production in radiation-induced senescent cells and promotes migration of inflammatory cells.
Free Radic Res. 2018;52(1):92-102.
doi: 10.1080/10715762.2017.1416112.
3) Ueno D, Mizukawa H, Inanami O, Nagasaka H, Tatsuta N, Narazaki Y, Fujino T, Watanabe I, Kameda Y, Nakai K.
“Caddisfly watch,” a biomonitoring program using Stenopsyche larvae to determine radioactive cesium contamination in rivers following the Fukushima nuclear disaster.
Landscape and Ecological Engineering. 2018;14(1):29?35.
doi: https://doi.org/10.1007/s11355-017-0333-y.
4) Yasui H, Kubota N, Nishizumi J, Sakai Y, Yamamori T, Inanami O. Preclinical study on hypoxic radiosensitizing effects of glycididazole in comparison with those of doranidazole in vitro and in vivo.
Oncol Lett. 2018;15(2):1993-1998.
doi: 10.3892/ol.2017.7481
5) Shino H, Otsuka-Yamasaki Y, Sato T, Ooi K, Inanami O, Sato R,Yamasaki M.
Familial Congenital Methemoglobinemia in Pomeranian Dogs Caused by a Missense Variant in the NADH-Cytochrome B5 Reductase Gene.
J Vet Intern Med. 2018;32(1):165-171
doi: 10.1111/jvim.15031
6）Yamamoto K, Ikenaka Y, Ichise T, Bo T, Ishizuka M, Yasui H, Hiraoka W, Yamamori T, Inanami O.
Evaluation of mitochondrial redox status and energy metabolism of X-irradiated HeLa cells by LC/UV, LC/MS/MS and ESR.
Free Radic Res. 2018;52:648-660.
doi: 10.1080/10715762.2018.1460472.
7）Nagane M, Kuppusamy ML, An J, Mast JM, Gogna R, Yasui H, Yamamori T, Inanami O, Kuppusamy P.
Ataxia-Telangiectasia Mutated (ATM) Kinase Regulates eNOS Expression and Modulates Radiosensitivity in Endothelial Cells Exposed to Ionizing Radiation.
Radiat Res. 2018;189(5):519-528.
doi: 10.1667/RR14781.1.
8）Komarov DA, Ichikawa Y, Yamamoto K, Stewart NJ, Matsumoto S, Yasui H, Kirilyuk IA, Khramtsov VV, Inanami O, Hirata H.
In Vivo Extracellular pH Mapping of Tumors Using Electron Paramagnetic Resonance.
Anal Chem. 2018;90(23):13938-13945.
doi: 10.1021/acs.analchem.8b03328.
9）Tomita M, Yasui H, Higashikawa K, Nakajima K, Takakura H, Shiga T, Kuge Y, Ogawa M.
Anti PD-1 treatment increases [18F]FDG uptake by cancer cells in a mouse B16F10 melanoma model.
EJNMMI Res. 2018;8(1):82.
doi: 10.1186/s13550-018-0433-1.
2017年
*Original articles
1）Kubota H, Komarov DA, Yasui H, Matsumoto S, Inanami O, Kirilyuk IA, Khramtsov W, Hirata H.
Feasibility of in vivo three-dimensional T 2* mapping using dicarboxy-PROXYL and CW-EPR-based single-point imaging. MAGMA. 2017 doi: 10.1007/s10334-016-0606-8. Jun;30(3):291-298.
PMID: 28063096
2) Kitaya T, Maeda T, Yasui H, Mizukawa H, Inanami O, Nakata A, Miura T, Hosokawa Y,Kuwabara M.
Attempts of Radiation Dose Measurement in the Teeth of Mice Living around the Nuclear Power Plant in Fukushima Using Electron Spin Resonance Spectroscopy.Rad. Envi. Med.2017:Vol.6,No.1 1-5
3) Yasui H, Yamamoto K, Suzuki M, Sakai Y, Bo T, Nagane M, Nishimura E, Yamamori T,Yamasaki T,Yamada KI, Inanami O.
Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells.Cancer lett.
2017Jan 16,390:160-67.doi:10.1016/j.canlet.2017.01.006.[Epub ahead of print] PMID:28093283
4)Lue S, Moritake T,Ito K,Matsumoto Y, Yasui H, Nakagawa H, Hirayama A, Inanami O,Tsuboi K.
Metabolic analysis of radioresistant medulloblastoma steam-like clones and potential therapeutic targets.
PLoS One. 2017 Apr 20;12(4):e0176162. doi: 10.1371/journal.pone.0176162. eCollection .
5)Suzuki M,Yamamori T,Bo T,Sakai Y, Inanami O.
MK-8776,a novel Chk1 inhibitor ,exhibits an improved radiosensitizing effect compared to UGN-01 by exacerbating radiation-induced aberrant mitosis.
Translational Oncology.2017 10(4):491-500. doi: 10.1016/j.tranon.2017.04.002. PMID: 28550769
6)Amida T, Nakaoka R, Komarov DA, Yamamoto K, Inanami O, Matsumoto S, Hirata H.
A 750-MHz electronically tunable resonator using microstrip line couplers for electron paramagnetic resonance imaging of a mouse tumor-bearing leg.
IEEE Trans Biomed Eng. 2017 Aug . doi: 10.1109/TBME.2017.2743232. PMID: 28841547
7)Yasui H, Kawai T, Matsumoto S, Saito K, Devasahayam N, Mitchell JB, Camphausen K, Inanami O, Krishna MC.
Quantitative imaging of pO2 in orthotopic murine gliomas: hypoxia correlates with resistance to radiation.
Free Radic Res. 2017 Oct;51(9-10):861-871. doi: 10.1080/10715762.2017.1388506. PMID: 29076398
2016年
*Original articles
1) Maeda K, Yasui H, Matsuura T, Yamamori T, Suzuki M, Nagane M, Nam JM, Inanami O, Shirato H. Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro. J Radiat Res. 2 57(3):307-11. doi: 10.1093/jrr/rrv101. 2016 Feb 1. PMID: 26838131
3) Maeda K, Yasui H, Yamamori T, Matsuura T, Takao S, Suzuki M, Matsuda A, Inanami O, Shirato H.
Ａ nucleoside Anticancer Drug, 1-(3-C-Etynyl- β-D-Ribo-Pentofuranosyl)Cytosine,Induces Depth-Dependent Enhancement of Tumor Cell Deth in Spread-Out Bragg Peak(SOBP)of Proton Beam.PLOS ONE .2016 November.doi:10.1371/journal.pone.0166848
4)Yamamori T, Sasagawa T, Ichii O, Hiyoshi M, Bo T, Yasui H, Kon Y, Inanami O. Analysis of the mechanism of radiation-induced upregulation of mitochondrial abundance in mouse fibroblasts.
J.Radiat Res.2016:1-10.doi:10.1093/jrr/rrw113
*Other publications
1） Inanami, O. 2016 酸化ストレスとミトコンドリア電子伝達系応答
2015年
*Original articles
1) Nagane, M.,Yasui, H., Sakai, Y., Yamamori, T., Niwa, K., Hattori, Y., Kondo, T., and Inanami, O. 2015 Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway.Biochem Biophys Res Commun. 2;456(1):541-6. doi:10.1016/j.bbrc.2014.12.002
2) Sakai, Y., Yamamori, T., Yasui, H.,and Inanami, O. 2015. Downregulation of the DNA repair enzyme apurinic/apyrimidinic endonuclease 1 stimulates transforming growth factor-β1 production and promotes actin rearrangement.Biochem Biophys Res Commun.22;461(1):35-41. doi: 10.1016/j.bbrc.2015.03.163. PMID: 25858321
3) Sakata, K., Kondo, T., Mizuno, N., Shoji, M., Yasui, H., Yamamori, T., Inanami, O., Yokoo, H., Yoshimura, N., and Hattori, Y. 2015 Roles of ROS and PKC-βII in ionizing radiation-induced eNOS activation in human vascular endothelial cells. Vascul Pharmacol; 70:55-65. doi: 10.1016/j.vph.
4）Yamamori, T., Ike, S., Bo, T., Sasagawa, T., Sakai, Y., Suzuki, M1., Yamamoto, K., Nagane, M., Yasui, H.,and Inanami, O. 2015 Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after X-irradiation. Mol Biol Cell, 26;4607-4617.
2013年
*Original articles
2012年
*Original articles
1) Eitaki, M., Yamamori, T., Meike, S., Yasui, H. and Inanami, O. 2012.Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells. BMC Cancer, 12:469.
2) Indo, HP., Inanami, O., Koumura, T., Suenaga, S., Yen, HC., Kakinuma, S., Matsumoto, K., Nakanishi, I., St, Clair. W., St, Clair. DK., Matsui, H., Cornette, R., Gusev, O., Okuda, T., Nakagawa, Y., Ozawa, T. and Majima, HJ. 2012. Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE. Free Radic Res, 46:1029-1043.
3) Yamamori, T., Yasui, H., Yamazumi, M., Wada, Y., Nakamura, Y., Nakamura, H. and Inanami, O. 2012. Ionizing radiation induces mitochondrial reactive oxygen species production accompanied by upregulation of mitochondrial electron transport chain function and mitochondrial content under control of the cell cycle checkpoint. Free Radic Biol Med, 53:260-270.
4) Saito, K., Matsumoto, S., Yasui, H., Devasahayam, N., Subramanian, S., Munasinghe, JP., Patel, V., Gutkind, JS., Mitchell, JB. and Krishna, MC. 2012. Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin.PLoS One, 7:e49456.
5) Krishna, MC., Matsumoto, S., Yasui, H., Saito, K., Devasahayam, N., Subramanian, S. and Mitchell, JB. 2012. Electron paramagnetic resonance imaging of tumor pO?.Radiat Res, 177:376-386.
2011年
*Original articles
1) Yamamori, T., Mizobata, A., Saito, Y., Urano, Y., Inanami, O., Irani, K. and Noguchi, N. 2011. Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity. Free Radical Research, 2011;45:342-350.
2) Meike, S., Yamamori, T., Yasui, H., Eitaki, M., Matsuda, A., and Inanami, O. 2011. 8-amino-adenosine Enhances Radiation-induced Cell Death in Human Lung Carcinoma A549 Cells. Journal of Radiation Research,2011;52:456-463.
3) Meike, S., Yamamori, T., Yasui, H., Eitaki, M., Matsuda, A., Morimatsu, M., Fukushima, M., Yamasaki, Y.,and Inanami, O. 2011. A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106),sensitizes cells to radiation by suppressing BRCA2 expression. Molecular Cancer, 2011;10:92
4) Kobayashi, S., Abe, Y,. Inanami, O., Oda, S., Yamauchi, K., Hankanga, C., Yasuda, J., Sato, R. 2011. Oral administration of bovine lactoferrin upregulates neutrophil functions in a dog with familial β2-integrin-related neutrophil dysfunction. Vet erinary Immunol ogy and Immunopathology, 2011;15:143:155-161
5) Matsumoto, S., Batra, S., Saito, K., Yasui, H., Choudhuri, R., Gadisetti, C., Subramanian , S., Devasahayam, N., Munasinghe, JP., Mitchell, JB., Krishna, MC. 2011. Antiangiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia.Cancer research ,2011;15:71:6350-6359
6) Yamanaka, K., Saito, Y., Yamamori, T., Urano, Y., Noguchi, N., 24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis. Journal of Biological Chemistry , 2011;286:24666-24673. *Publications
1) Yamamori, T. and Irani, K. 2010. Deacetylation of AP endonuclease 1 by Sirt1 regulates DNA base excision repair activity. Biomedical Gerontology, 2011; 35:29-32.(in Japanese)
2) Yamamori, T. and Irani, K. 2011. Regulation of DNA repair enzyme AP endonuclease 1 by lifespan regulation-related protein Sirt1. The Journal of the Hokkaido Veterinary Medical Association, 2011; 55:45-49. (in Japanese)
2010年
*Original articles
1) Yamamori, T., DeRicco, J., Naqvi A, Hoffman TA., Mattagajasingh, I., Kasuno, K., Jung SB, Kim CS., and Irani, K.. 2010 SIRT1 deacetylates APE1 and regulates cellular base excision repair. Nucleic Acids Research, 38:832-845.
2) Asanuma, T., Ono, M., kubota, K., Hirose, A., Hayashi, Y., Saibara, T., Inanami, O., Enzan, H., Onishi, S., Kuwabara, M., and Oben, JA. 2010 Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease. Gut, 59:258-266.
3) Yasui, H., Ito, N., Yamamori, T., Nakamura, H., Okano, J., Asanuma, T., Nakajima, T., Kuwabara, M.,and Inanami, O. 2010 Induction of neurite outgrowth by alpha-phenyl-N-tert-butylnitrone through nitric oxide release and Ras-ERK pathway in PC12 cells. Free Radical Research, 44:645-654
4) Watanabe, Y., Hiraoka, W., Igarashi, M., Ito, K., Shimoyama, Y., Horiuchi, M., Yamamori, T., Yasui, H., Kuwabara, M., Inagaki, F., and Inanami, O. 2010 A novel copper(II) coordination at His186 in full-length murine prion protein. Biochemical and Biophysical Research Communications, 394:522-528
5) Yasui, H., Matsumoto, S., Devasahayam, N., Munasinghe, JP., Choudhuri, R., Saito, K.., Subramanian, S., Mitchell, JB., and Krishna, MC. 2010 Low-Field Magnetic Resonance Imaging to Visualize Chronic and Cycling Hypoxia in Tumor-Bearing Mice. Cancer Research, 70:6427-6436
6) Jung SB, Kim CS, Naqvi A, Yamamori T, Mattagajasingh I, Hoffman T, Cole M, Kumar A, Dericco J, Jeon BH, Irani K. Histone Deacetylase-3 Antagonizes Aspirin-Stimulated Endothelial Nitric Oxide Production by Reversing Aspirin-Induced Lysine Acetylation of Endothelial Nitric Oxide Synthase. Circulation Research, 2010;107(7):877-87.
7) Naqvi A, Hoffman T, Dericco J, Kumar A, Kim CS, Jung SB, Yamamori T, Kim Y, Mehdi F, Kumar S, Rankinen T, Ravussin E, Irani K. A single nucleotide variation in a p53 binding site affects nutrient-sensitive human SIRT1 expression. Human Molecular Genetics, 2010; 19(21):4123-33 8) Matsumoto, S., Yasui, H., Mitchell, JB., and Krishna, MC. 2010.Imaging cycling tumor hypoxia.Cancer Research, 70:10019-10023
*Publications
1） Yasui, H., Yamamori. T., Meike, S., Eitaki, M., Iizuka, D., Kuwabara, M., and Inanami, O. 2010.New insight into hypoxia-targeting cancer therapy. Radiation Biology Research Communications, 45: 45-57. (in Japanese)
2) Yasui, H. 2010. Report of overseas research experience, Spin Science, 14: 51-53. (in Japanese)
*Original articles
1）Ogawara K, Inanami O, Takakura H, Saita K, Nakajima K, Kumar S, Ieda N, Kobayashi M, Taketsugu T, Ogawa M
Theoretical Design and Synthesis of Caged Compounds Using X-Ray-Triggered Azo Bond Cleavage.
Adv Sci (Weinh). 11(12), e2306586, 2024.
doi: 10.1002/advs.202306586
2）Kato-Suzuki M, Okamatsu-Ogura Y, Inanami O, Kimura K.
Time-dependent changes in retinoids content in liver and adipose tissue after feeding of a vitamin A-deficient diet to mice.
Exp Anim. 73, 302-309, 2024.
doi: 10.1538/expanim.23-0123
3) Goto Y, Ando K, Takakura H, Nakajima K, Kobayashi M, Inanami O, Taketsugu T, Ogawa M.
Development of a red-shifted photosensitizer for near-infrared photoimmunotherapy of cancer.
J Photochem Photobiol. 20, 100230, 2024.
doi: 10.1016/j.jpap.2024.100230
4) Tada T, Mizuno Y, Shibata Y, Yasui H, Kuge Y.
Application of copper (I) selective ligands for PET imaging of reactive oxygen species through metabolic trapping.
Nucl Med Biol. 134-135, 108914, 2024
doi: 10.1016/j.nucmedbio.2024.108914
5) Kato K, Yasui H, Sato-Akaba H, Emoto MC, Fujii HG, Kmiec MM, Kuppusamy P, Mizuno Y, Kuge Y, Nagane M, Yamashita T, Inanami O.
Feasibility study of multimodal imaging for redox status and glucose metabolism in tumor.
Free Radic Biol Med. 218, 57-67, 2024.
doi: 10.1016/j.freeradbiomed.2024.03.028
6) Oba M, Taguchi M, Kudo Y, Yamashita K, Yasui H, Matsumoto S, Kirilyuk IA, Inanami O, Hirata H.
Partial Acquisition of Spectral Projections Accelerates Four-dimensional Spectral-spatial EPR Imaging for Mouse Tumor Models: A Feasibility Study.
Mol Imaging Biol. 26, 459-472, 2024.
doi: 10.1007/s11307-024-01924-y
7) Yamashita K, Yasui H, Bo T, Fujimoto M, Inanami O.
Mechanism of the Radioresistant Colorectal Cancer Cell Line SW480RR Established after Fractionated X Irradiation.
Radiat Res. 202, 38-50, 2024
doi: 10.1667/RADE-23-00021.1
8) Kitamura H, Fujimoto M, Hashimoto M, Yasui H, Inanami O.
USP2 Mitigates Reactive Oxygen Species-Induced Mitochondrial Damage via UCP2 Expression in Myoblasts.
Int J Mol Sci. 25, 11936, 2024.
doi: 10.3390/ijms252211936
9) Higashikawa K, Uehara R, Horiguchi S, Shibata Y, Okubo N, Mizuno Y, Yasui H, Ohnishi S, Takeda H, Kuge Y.
Thymidine Phosphorylase Imaging Probe for Differential Diagnosis of Metabolic dysfunction-associated Steatohepatitis.
Mol Imaging Biol. 26, 1036-1045, 2024
doi: 10.1007/s11307-024-01964-4
10) Yamaguchi M, Htun KT, Tatara Y, Sato Y, Hosoda M, Kothan S, Kamimura C, Inanami O, Kashiwakura I.
Radio-protective effects of ultra-fine bubble hydrogen water and serum protein responses in whole-body radiation-exposed mice.
Radiat Res. Sci Rep 15, 4447, 2025
doi: 10.1038/s41598-025-87963-z
11) Miyazono K, Tomihari M, Arashiki N, Koshino I, Otsuka-Yamasaki Y, Kizaki K, Tsukamoto T, Inanami O, Deguchi A, Kitaguchi E, Demura M, Mohandas N, Takakuwa Y, Inaba M.
Red cell shape regulation by band 3–ankyrin–spectrin linkage: Implications for clinical severity of bovine HS.
Blood Red Cells & Iron. 2025.
doi: 10.1016/j.brci.2025.100003
12) Ogawara K, Ieda N, Takakura H, Nakajima K, Mukaimine A, Harada M, Hashimoto K, Inanami O, Ogawa M.
Effect of hydroxy groups on X-ray-induced reactions of azo benzene derivatives.
Org Biomol Chem. 2025
doi: 10.1039/d5ob00003c
2023年
*Original articles
1）Nakajima K, Sugikawa A, Yasui H, Higashikawa K, Suzuki C, Natsume T, Suzuki M, Takakura H, Tomita M, Takahashi S, Hirata K, Magata Y, Kuge Y, Ogawa M.
In vivo imaging of acute physiological responses after treatment of cancer with near-infrared photoimmunotherapy.
Mol Imaging Biol. 25(4), 648-658, 2023.
doi: 10.1007/s11307-023-01822-9
*Other publications
1） 安井博宣, 小澤拓実, 藤本政毅, 稲波修. 老化細胞標的がん治療 -がんセノセラピー-に向けた基礎研究. Precision Medicine 6(13), 1096-1100, 2023
2022年
*Original articles
1）Fujimoto M, Higashiyama R, Yasui H, Yamashita K, Inanami O.
Preclinical studies for improving radiosensitivity of non-small cell lung cancer cell lines by combining glutaminase inhibition and senolysis.
Transl Oncol. 21, 101431, 2022.
doi: 10.1016/j.tranon.2022.101431
2) Hashimoto M, Fujimoto M, Konno K, Lee ML, Yamada Y, Yamashita K, Toda C, Tomura M, Watanabe M, Inanami O, Kitamura H.
Ubiquitin-specific protease 2 in the ventromedial hypothalamus modifies blood glucose levels by controlling sympathetic nervous activation.
J Neurosci. 42(23), 4607-4618, 2022.
doi: 10.1523/JNEUROSCI.2504-21.2022
3) Takakura H, Matsuhiro S, Inanami O, Kobayashi M, Saita K, Yamashita M, Nakajima K, Suzuki M, Miyamoto N, Taketsugu T, Ogawa M.
Ligand release from silicon phthalocyanine dyes triggered by X-ray irradiation.
Org Biomol Chem. 20(36), 7270-7277, 2022
doi: 10.1039/d2ob00957a
4) Kawai T, Matsuo M, Takakusagi Y, Saito K, Hyodo F, Devasahayam N, Matsumoto S, Kishimoto S, Yasui H, Yamamoto K, Krishna MC.
Continuous monitoring of postirradiation reoxygenation and cycling hypoxia using electron paramagnetic resonance imaging.
NMR Biomed. 35(10), e4783, 2022.
doi: 10.1002/nbm.4783
5) Takamiya S, Kawabori M, Kitahashi T, Nakamura K, Mizuno Y, Yasui H, Kuge Y, Tanimori A, Takamatsu Y, Yuyama K, Shichinohe H, Fujimura M.
Intracerebral transplantation of mesenchymal stromal cell compounded with recombinant peptide scaffold against chronic intracerebral hemorrhage model.
Stem Cells Int. 2022, 8521922, 2022.
doi: 10.1155/2022/8521922
6) Nakaoka R, Kato K, Yamamoto K, Yasui H, Matsumoto S, Kirilyuk IA, Khramtsov VV, Inanami O, Hirata H.
Electron paramagnetic resonance implemented with multiple harmonic detections successfully maps extracellular pH in vivo.
Anal Chem. 95(8), 3940-3950, 2022
doi: 10.1021/acs.analchem.2c03194
*Other publications
1） 安井博宣, 小澤拓実, 藤本政毅, 稲波修. 細胞老化の制御に基づく新しいがん治療戦略. 細胞 55(2), 115-118, 2023
2021年
*Original articles
1）Nagane M, Yasui H, Kuppusamy P, Yamashita T, Inanami O.
DNA damage response in vascular endothelial senescence: Implication for radiation-induced cardiovascular diseases.
J Radiat Res. 62(4), 564-573, 2021.
doi: 10.1093/jrr/rrab032
2) Gulay KCM, Aoshima K, Shibata Y, Yasui H, Yan Q, Kobayashi A, Kimura T.
Kdm2b promotes cell viability by enhancing DNA 1 damage response in canine hemangiosarcoma.
J Genet Genom. 48(7), 618-630, 2021.
doi: 10.1016/j.jgg.2021.02.005.
3) Deguchi T, Hosoya K, Kim S, Murase Y, Yamamoto K, Bo T, Yasui H, Inanami O, Okumura M.
Metformin preferentially enhances the radiosensitivity of cancer stem-like cells with highly mitochondrial respiration ability in canine osteosarcoma cell line.
Mol Ther Oncolytics. 22, 143-151, 2021
doi: 10.1016/j.omto.2021.08.007
4) Bo T, Kobayashi S, Inanami O, Fujii J, Nakajima O, Ito T, Yasui H.
LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence.
Transl Oncol. 14(11), 101212, 2021.
doi: 10.1016/j.tranon.2021.101212
5) Kato T, Okada R, Goto Y, Furusawa A, Inagaki F, Wakiyama H, Furumoto H, Daar D, Turkbey B, Choyke PL, Takakura H, Inanami O, Ogawa M, Kobayashi H.
Electron Donors Rather Than Reactive Oxygen Species Needed for Therapeutic Photochemical Reaction of Near-Infrared Photoimmunotherapy.
ACS Pharmacol Transl Sci. 4(5), 1689-1701, 2021.
doi: 10.1021/acsptsci.1c00184
6) Kimura K, Iguchi N, Nakano H, Yasui H, Matsumoto S, Inanami O, Hirata H.
Redox-sensitive mapping of a mouse tumor model using sparse projection sampling of electron paramagnetic resonance.
Antioxid Redox Signal. 36(1-3), 57-69, 2022
doi: 10.1089/ars.2021.0003
7) Bo T, Yasui H, Shiga T, Shibata Y, Fujimoto M, Suzuki M, Higashikawa K, Miyamoto N, Inanami O, Kuge Y.
Eribulin improves tumor oxygenation demonstrated by 18F-DiFA hypoxia imaging, leading to radio-sensitization in human cancer xenograft models.
Eur J Nucl Med Mol Imaging. 49(3), 821-833, 2022.
doi: 10.1007/s00259-021-05544-4
8) Inanami O, Hiraoka W, Goto Y, Takakura H, Ogawa M.
EPR Characterisation of Phthalocyanine Radical Anions in Near-Infrared Photocleavage of the Hydrophilic Axial Ligand of a Photoimmunotherapeutic Reagent, IR700.
ChemPhotoChem. 6(1), e202100172, 2022.
doi: 10.1002/cptc.202100172
*Other publications
1） 稲波修, 安井博宣. ナノ粒子による腫瘍細胞における放射線増感機構. 化学工業 72(4), 238-243, 2021
2） 藤本政毅, 安井博宣, 稲波修. グルタミン代謝阻害とセノリシスを組み合わせた新しい放射線治療の可能性. 細胞 53(12), :698-701, 2021
2020年
*Original articles
1）Higashikawa K, Horiguchi S, Tarisawa M, Shibata Y, Ohkura K, Yasui H, Takeda H, Kuge Y.
Preclinical investigation of potential use of thymidine phosphorylase-targeting tracer for diagnosis of nonalcoholic steatohepatitis.
Nucl Med Biol. 2020;82-83:25-32.
doi: 10.1016/j.nucmedbio.2019.12.006.
2) Yasui H, Iizuka D, Hiraoka W, Kuwabara M, Matsuda A, Inanami O.
Nucleoside analogs as a radiosensitizer modulating DNA repair, cell cycle checkpoints, and apoptosis.
Nucleosides, Nucleotides and Nucleic Acids. 2020;39(1-3):439-452.
doi: 10.1080/15257770.2019.1670839.
3) Bo T, Yamamori T, Yamamoto K, Fujimoto M, Yasui H, Inanami O.
Mitochondrial fission promotes radiation-induced increase in intracellular Ca2+ level leading to mitotic catastrophe in mouse breast cancer EMT6 cells.
Biochem Biophys Res Commun. 2020;522(1):144-150.
doi: 10.1016/j.bbrc.2019.11.027
4) Wang Z, Higashikawa K, Yasui H, Kuge Y, Ohno Y, Kihara A, Yenari M, Houkin K, Kawabori M.
FTY720 protects against ischemia–reperfusion injury by preventing the redistribution of tight junction proteins and decreases inflammation in the sub-acute phase in an experimental stroke model.
Transl Stroke Res. 2020;11(5):1103-1116.
doi: 10.1007/s12975-020-00789-x
5) Fujimoto M, Bo T, Yamamoto K, Yasui H, Yamamori T, Inanami O
Radiation-induced abnormal centrosome amplification and mitotic catastrophe in human cervical tumor HeLa cells and murine mammary tumor EMT6 cells.
J Clin Biochem Nutr. 2020;67(3):240-247.
doi: 10.3164/jcbn.19-80
6) Oiwa Y, Oka K, Yasui H, Higashikawa K, Bono H, Kawamura Y, Miyawaki S, Watarai A, Kikusui T, Shimizu A, Okano H, Kuge Y, Kimura K, Okamatsu-Ogura Y, Miura K.
Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal.
Sci Rep. 2020;10(1):19488.
doi: 10.1038/s41598-020-74929-6
*Other Publications
1） Yasui H, Matsumoto S, Inanami O, Krishna M.C.
Imaging of Tumor-Specific Hypoxia Dynamics and Its Significance in Radiation Biology.
Igaku Butsuri. 2020;40(1):13-18. (in Japanese)
2019年
*Original articles
1) Yoneshiro T, Shin W, Machida K, Fukano K, Tsubota A, Chen Y, Yasui H, Inanami O, Okamatsu-Ogura Y, Kimura, K.
Differentiation of bone marrow?derived cells toward thermogenic adipocytes in white adipose tissue induced by the β3 adrenergic stimulation.
FASEB J. 2019;33(4):5196-5207.
doi: 10.1096/fj.201801757RR.
2) Bhilwade HN, Tatewaki N, Konishi T, Nishida M, Eitsuka T, Yasui H, Inanami O, Handa O, Naito Y, Ikekawa N, Nishida, H..
The Adjuvant Effect of Squalene, an Active Ingredient of Functional Foods, on Doxorubicin-Treated Allograft Mice.
Nutr Cancer. 2019;10:1-12.
doi: 10.1080/01635581.2019.1597900.
3) Watanabe S, Shiga T, Hirata K, Magota K, Okamoto S, Toyonaga T, Higashikawa K, Yasui H, Kobayashi J, Nishijima KI, Iseki K, Matsumoto H, Kuge Y, Tamaki N.
Biodistribution and Radiation Dosimetry of the Novel Hypoxia PET Probe [18F]DiFA and comparison with [18F]FMISO.
EJNMMI Res. 2019;9(1):60.
doi: 10.1186/s13550-019-0525-6.
4) Morita A, Gulay KCM, Onishi S, Shibata Y, Yasui H, Kobayashi A, Kimura T.
High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines.
Res Vet Sci. 2019;127:1-10
doi: 10.1016/j.rvsc.2019.09.011.
5）Hashimoto M, Saito N, Ohta H, Yamamoto K, Tashiro A, Nakazawa K, Inanami O, Kitamura H.
Inhibition of ubiquitin-specific protease 2 causes accumulation of reactive oxygen species, mitochondria dysfunction, and intracellular ATP decrement in C2C12 myoblasts.
Physiol Rep. 2019;7(14):e14193.
doi: 10.14814/phy2.14193.
6）Bo T, Yamamori T, Yamamoto K, Fujimoto M, Yasui H, Inanami O.
Mitochondrial fission promotes radiation-induced increase in intracellular Ca2+ level leading to mitotic catastrophe in mouse breast cancer EMT6 cells.
Biochem Biophys Res Commun. 2019;522(1):144-150.
doi: 10.1016/j.bbrc.2019.11.027.
7）Shibata Y, Yasui H, Higashikawa K, Miyamoto N, Kuge Y.
Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo.
PLoS One. 2019;14(12):e0225931.
doi: 10.1371/journal.pone.0225931.
8）Shimizu Y, Zhao S, Yasui H, Nishijima KI, Matsumoto H, Shiga T, Tamaki N, Ogawa M, Kuge Y.
A Novel PET Probe "[18F]DiFA" Accumulates in Hypoxic Region via Glutathione Conjugation Following Reductive Metabolism.
Mol Imaging Biol. 2019;21(1):122-129.
doi: 10.1007/s11307-018-1214-y.
2018年
*Original articles
1) Bo T, Yamamori T, Suzuki M, Sakai Y, Yamamoto K, Inanami O.
Calmodulin-dependent protein kinase II (CaMKII) mediates radiation-induced mitochondrial fission by regulating the phosphorylation of dynamin-related protein 1 (Drp1) at serine 616.
Biochem Biophys Res Commun. 2018;495(2):1601-1607.
doi: 10.1016/j.bbrc.2017.12.012.
2) Sakai Y, Yamamori T, Yoshikawa Y, Bo T, Suzuki M, Yamamoto K, Ago T, Inanami O.
NADPH oxidase 4 mediates ROS production in radiation-induced senescent cells and promotes migration of inflammatory cells.
Free Radic Res. 2018;52(1):92-102.
doi: 10.1080/10715762.2017.1416112.
3) Ueno D, Mizukawa H, Inanami O, Nagasaka H, Tatsuta N, Narazaki Y, Fujino T, Watanabe I, Kameda Y, Nakai K.
“Caddisfly watch,” a biomonitoring program using Stenopsyche larvae to determine radioactive cesium contamination in rivers following the Fukushima nuclear disaster.
Landscape and Ecological Engineering. 2018;14(1):29?35.
doi: https://doi.org/10.1007/s11355-017-0333-y.
4) Yasui H, Kubota N, Nishizumi J, Sakai Y, Yamamori T, Inanami O. Preclinical study on hypoxic radiosensitizing effects of glycididazole in comparison with those of doranidazole in vitro and in vivo.
Oncol Lett. 2018;15(2):1993-1998.
doi: 10.3892/ol.2017.7481
5) Shino H, Otsuka-Yamasaki Y, Sato T, Ooi K, Inanami O, Sato R,Yamasaki M.
Familial Congenital Methemoglobinemia in Pomeranian Dogs Caused by a Missense Variant in the NADH-Cytochrome B5 Reductase Gene.
J Vet Intern Med. 2018;32(1):165-171
doi: 10.1111/jvim.15031
6）Yamamoto K, Ikenaka Y, Ichise T, Bo T, Ishizuka M, Yasui H, Hiraoka W, Yamamori T, Inanami O.
Evaluation of mitochondrial redox status and energy metabolism of X-irradiated HeLa cells by LC/UV, LC/MS/MS and ESR.
Free Radic Res. 2018;52:648-660.
doi: 10.1080/10715762.2018.1460472.
7）Nagane M, Kuppusamy ML, An J, Mast JM, Gogna R, Yasui H, Yamamori T, Inanami O, Kuppusamy P.
Ataxia-Telangiectasia Mutated (ATM) Kinase Regulates eNOS Expression and Modulates Radiosensitivity in Endothelial Cells Exposed to Ionizing Radiation.
Radiat Res. 2018;189(5):519-528.
doi: 10.1667/RR14781.1.
8）Komarov DA, Ichikawa Y, Yamamoto K, Stewart NJ, Matsumoto S, Yasui H, Kirilyuk IA, Khramtsov VV, Inanami O, Hirata H.
In Vivo Extracellular pH Mapping of Tumors Using Electron Paramagnetic Resonance.
Anal Chem. 2018;90(23):13938-13945.
doi: 10.1021/acs.analchem.8b03328.
9）Tomita M, Yasui H, Higashikawa K, Nakajima K, Takakura H, Shiga T, Kuge Y, Ogawa M.
Anti PD-1 treatment increases [18F]FDG uptake by cancer cells in a mouse B16F10 melanoma model.
EJNMMI Res. 2018;8(1):82.
doi: 10.1186/s13550-018-0433-1.
2017年
*Original articles
1）Kubota H, Komarov DA, Yasui H, Matsumoto S, Inanami O, Kirilyuk IA, Khramtsov W, Hirata H.
Feasibility of in vivo three-dimensional T 2* mapping using dicarboxy-PROXYL and CW-EPR-based single-point imaging. MAGMA. 2017 doi: 10.1007/s10334-016-0606-8. Jun;30(3):291-298.
PMID: 28063096
2) Kitaya T, Maeda T, Yasui H, Mizukawa H, Inanami O, Nakata A, Miura T, Hosokawa Y,Kuwabara M.
Attempts of Radiation Dose Measurement in the Teeth of Mice Living around the Nuclear Power Plant in Fukushima Using Electron Spin Resonance Spectroscopy.Rad. Envi. Med.2017:Vol.6,No.1 1-5
3) Yasui H, Yamamoto K, Suzuki M, Sakai Y, Bo T, Nagane M, Nishimura E, Yamamori T,Yamasaki T,Yamada KI, Inanami O.
Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells.Cancer lett.
2017Jan 16,390:160-67.doi:10.1016/j.canlet.2017.01.006.[Epub ahead of print] PMID:28093283
4)Lue S, Moritake T,Ito K,Matsumoto Y, Yasui H, Nakagawa H, Hirayama A, Inanami O,Tsuboi K.
Metabolic analysis of radioresistant medulloblastoma steam-like clones and potential therapeutic targets.
PLoS One. 2017 Apr 20;12(4):e0176162. doi: 10.1371/journal.pone.0176162. eCollection .
5)Suzuki M,Yamamori T,Bo T,Sakai Y, Inanami O.
MK-8776,a novel Chk1 inhibitor ,exhibits an improved radiosensitizing effect compared to UGN-01 by exacerbating radiation-induced aberrant mitosis.
Translational Oncology.2017 10(4):491-500. doi: 10.1016/j.tranon.2017.04.002. PMID: 28550769
6)Amida T, Nakaoka R, Komarov DA, Yamamoto K, Inanami O, Matsumoto S, Hirata H.
A 750-MHz electronically tunable resonator using microstrip line couplers for electron paramagnetic resonance imaging of a mouse tumor-bearing leg.
IEEE Trans Biomed Eng. 2017 Aug . doi: 10.1109/TBME.2017.2743232. PMID: 28841547
7)Yasui H, Kawai T, Matsumoto S, Saito K, Devasahayam N, Mitchell JB, Camphausen K, Inanami O, Krishna MC.
Quantitative imaging of pO2 in orthotopic murine gliomas: hypoxia correlates with resistance to radiation.
Free Radic Res. 2017 Oct;51(9-10):861-871. doi: 10.1080/10715762.2017.1388506. PMID: 29076398
2016年
*Original articles
1) Maeda K, Yasui H, Matsuura T, Yamamori T, Suzuki M, Nagane M, Nam JM, Inanami O, Shirato H. Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro. J Radiat Res. 2 57(3):307-11. doi: 10.1093/jrr/rrv101. 2016 Feb 1. PMID: 26838131
2) Suzuki M. Yamamori T, Yasui H, Inanami O.Effects of MPS1 inhibition on genotoxic stress responses in murine tumor cells.
Anticancer Res. 36(6):2783-92.2016 Jun PMID: 272727893) Maeda K, Yasui H, Yamamori T, Matsuura T, Takao S, Suzuki M, Matsuda A, Inanami O, Shirato H.
Ａ nucleoside Anticancer Drug, 1-(3-C-Etynyl- β-D-Ribo-Pentofuranosyl)Cytosine,Induces Depth-Dependent Enhancement of Tumor Cell Deth in Spread-Out Bragg Peak(SOBP)of Proton Beam.PLOS ONE .2016 November.doi:10.1371/journal.pone.0166848
4)Yamamori T, Sasagawa T, Ichii O, Hiyoshi M, Bo T, Yasui H, Kon Y, Inanami O. Analysis of the mechanism of radiation-induced upregulation of mitochondrial abundance in mouse fibroblasts.
J.Radiat Res.2016:1-10.doi:10.1093/jrr/rrw113
*Other publications
1） Inanami, O. 2016 酸化ストレスとミトコンドリア電子伝達系応答
2015年
*Original articles
1) Nagane, M.,Yasui, H., Sakai, Y., Yamamori, T., Niwa, K., Hattori, Y., Kondo, T., and Inanami, O. 2015 Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway.Biochem Biophys Res Commun. 2;456(1):541-6. doi:10.1016/j.bbrc.2014.12.002
2) Sakai, Y., Yamamori, T., Yasui, H.,and Inanami, O. 2015. Downregulation of the DNA repair enzyme apurinic/apyrimidinic endonuclease 1 stimulates transforming growth factor-β1 production and promotes actin rearrangement.Biochem Biophys Res Commun.22;461(1):35-41. doi: 10.1016/j.bbrc.2015.03.163. PMID: 25858321
3) Sakata, K., Kondo, T., Mizuno, N., Shoji, M., Yasui, H., Yamamori, T., Inanami, O., Yokoo, H., Yoshimura, N., and Hattori, Y. 2015 Roles of ROS and PKC-βII in ionizing radiation-induced eNOS activation in human vascular endothelial cells. Vascul Pharmacol; 70:55-65. doi: 10.1016/j.vph.
4）Yamamori, T., Ike, S., Bo, T., Sasagawa, T., Sakai, Y., Suzuki, M1., Yamamoto, K., Nagane, M., Yasui, H.,and Inanami, O. 2015 Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after X-irradiation. Mol Biol Cell, 26;4607-4617.
2014年
*Original articles
1)Nishida, N.,Yasui, H., Nagane, M.,Yamamori, T and Inanami, O.. 2014 3-Methyl
pyruvate enhances radiosensitivity through increasing mitochondria-derived
reactive oxygen species in tumor cell lines. j.Radiat.Res .1-9.doi:10.1093/jrr/rrt142
2)Goodwin, J., Yachi, K., Nagane, M., Yasui, H., Miyake, Y., Inanami, O.,
Bobko, AA., Khramtsov, VV., Hirata, H. 2014 .In vivo tumour extracellular
pH monitoring using electron paramagnetic resonance: the effect of X-ray
irradiation. NMR Biomed., 27(4):453-8. doi: 10.1002/nbm.3081.
3)Yasui, H., Takeuchi, R., Nagane, M., Meike, S., Nakamura, Y., Yamamori, T., Ikenaka, Y., Kon, Y., Murotani, H., Oishi, M., Nagasaki, Y., Inanami, O. 2014 Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles. Cancer Lett., 28;347(1):151-8. doi: 10.1016/j.canlet.
4)Kuwabara, M., Hiraoka, W., Inanami, O. 2014 Ionizing radiation produces many kinds of free radicals in biologically important molecules through direct or indirect actions. Applications of EPR in Radiation Res., doi:10.1007/978-3-319-09216-4_9
*Publications
1) Yasui, H., Kaida, A., Hyodo, F., Miura, H., Kuge, Y., Matsumoto, Y.2014.
Innovative imaging techniques for exploiting novel cancer radiation biology.
Rad.Biol.Res.Com., 2014; 49:263-283.(in Japanese)
2013年
*Original articles
1)Nagane, M., Yasui, H., Yamamori, T., Zhao, S., kuge, Y., Tamaki, N., Kameya, H., Nakamura, H., Fujii, H. and Inanami, O. 2013 Radiation-induced nitric oxide mitigates tumor hypoxia and radioresistance in a murine SCCVII tumor model.Biochem Biophy Res Commun.437:420-425.
2)Yasui, H., Asanuma, T., Kino, J, Yamamori, T., Meike, S., Nagane, M., Kubota, N., and Inanami, O. 2013 The prospective application of a hypoxic radiosensitizer, doranidazole to rat intracranial glioblastoma with blood brain barrier disruption. BMC Cancer, 13:106.
3) Jung ,SB., Kim, CS., Kim, YR, Naqvi, A., Yamamori, T., Kumar, S., Kumar, A., and Irani, K. 2013 Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain. PLoS One, 8;e65415
4） Matsumoto, S., Saito, K., Yasui, H., Morris, HD., Munasinghe, JP., Lizak, M., Merkle, H., Ardenkjaer-Larsen, JH., Choudhuri, R., Devasahayam, N., Subramanian, S., Koretsky, AP., Mitchell, JB., and Krishna, MC.2013 EPR oxygen imaging and hyperpolarized 13C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate.Magn Reson Med,,
69(5):1443-1450
5) Yamamori, T.,Meike, S., Nagane, M., Yasui, H., and Inanami, O. 2013 ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51.FEBS Letters, 11;587(20):3348-53. doi: 10.1016/j.febslet.2013.08.030.
2012年
*Original articles
1) Eitaki, M., Yamamori, T., Meike, S., Yasui, H. and Inanami, O. 2012.Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells. BMC Cancer, 12:469.
2) Indo, HP., Inanami, O., Koumura, T., Suenaga, S., Yen, HC., Kakinuma, S., Matsumoto, K., Nakanishi, I., St, Clair. W., St, Clair. DK., Matsui, H., Cornette, R., Gusev, O., Okuda, T., Nakagawa, Y., Ozawa, T. and Majima, HJ. 2012. Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE. Free Radic Res, 46:1029-1043.
3) Yamamori, T., Yasui, H., Yamazumi, M., Wada, Y., Nakamura, Y., Nakamura, H. and Inanami, O. 2012. Ionizing radiation induces mitochondrial reactive oxygen species production accompanied by upregulation of mitochondrial electron transport chain function and mitochondrial content under control of the cell cycle checkpoint. Free Radic Biol Med, 53:260-270.
4) Saito, K., Matsumoto, S., Yasui, H., Devasahayam, N., Subramanian, S., Munasinghe, JP., Patel, V., Gutkind, JS., Mitchell, JB. and Krishna, MC. 2012. Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin.PLoS One, 7:e49456.
5) Krishna, MC., Matsumoto, S., Yasui, H., Saito, K., Devasahayam, N., Subramanian, S. and Mitchell, JB. 2012. Electron paramagnetic resonance imaging of tumor pO?.Radiat Res, 177:376-386.
2011年
*Original articles
1) Yamamori, T., Mizobata, A., Saito, Y., Urano, Y., Inanami, O., Irani, K. and Noguchi, N. 2011. Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity. Free Radical Research, 2011;45:342-350.
2) Meike, S., Yamamori, T., Yasui, H., Eitaki, M., Matsuda, A., and Inanami, O. 2011. 8-amino-adenosine Enhances Radiation-induced Cell Death in Human Lung Carcinoma A549 Cells. Journal of Radiation Research,2011;52:456-463.
3) Meike, S., Yamamori, T., Yasui, H., Eitaki, M., Matsuda, A., Morimatsu, M., Fukushima, M., Yamasaki, Y.,and Inanami, O. 2011. A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106),sensitizes cells to radiation by suppressing BRCA2 expression. Molecular Cancer, 2011;10:92
4) Kobayashi, S., Abe, Y,. Inanami, O., Oda, S., Yamauchi, K., Hankanga, C., Yasuda, J., Sato, R. 2011. Oral administration of bovine lactoferrin upregulates neutrophil functions in a dog with familial β2-integrin-related neutrophil dysfunction. Vet erinary Immunol ogy and Immunopathology, 2011;15:143:155-161
5) Matsumoto, S., Batra, S., Saito, K., Yasui, H., Choudhuri, R., Gadisetti, C., Subramanian , S., Devasahayam, N., Munasinghe, JP., Mitchell, JB., Krishna, MC. 2011. Antiangiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia.Cancer research ,2011;15:71:6350-6359
6) Yamanaka, K., Saito, Y., Yamamori, T., Urano, Y., Noguchi, N., 24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis. Journal of Biological Chemistry , 2011;286:24666-24673. *Publications
1) Yamamori, T. and Irani, K. 2010. Deacetylation of AP endonuclease 1 by Sirt1 regulates DNA base excision repair activity. Biomedical Gerontology, 2011; 35:29-32.(in Japanese)
2) Yamamori, T. and Irani, K. 2011. Regulation of DNA repair enzyme AP endonuclease 1 by lifespan regulation-related protein Sirt1. The Journal of the Hokkaido Veterinary Medical Association, 2011; 55:45-49. (in Japanese)
2010年
*Original articles
1) Yamamori, T., DeRicco, J., Naqvi A, Hoffman TA., Mattagajasingh, I., Kasuno, K., Jung SB, Kim CS., and Irani, K.. 2010 SIRT1 deacetylates APE1 and regulates cellular base excision repair. Nucleic Acids Research, 38:832-845.
2) Asanuma, T., Ono, M., kubota, K., Hirose, A., Hayashi, Y., Saibara, T., Inanami, O., Enzan, H., Onishi, S., Kuwabara, M., and Oben, JA. 2010 Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease. Gut, 59:258-266.
3) Yasui, H., Ito, N., Yamamori, T., Nakamura, H., Okano, J., Asanuma, T., Nakajima, T., Kuwabara, M.,and Inanami, O. 2010 Induction of neurite outgrowth by alpha-phenyl-N-tert-butylnitrone through nitric oxide release and Ras-ERK pathway in PC12 cells. Free Radical Research, 44:645-654
4) Watanabe, Y., Hiraoka, W., Igarashi, M., Ito, K., Shimoyama, Y., Horiuchi, M., Yamamori, T., Yasui, H., Kuwabara, M., Inagaki, F., and Inanami, O. 2010 A novel copper(II) coordination at His186 in full-length murine prion protein. Biochemical and Biophysical Research Communications, 394:522-528
5) Yasui, H., Matsumoto, S., Devasahayam, N., Munasinghe, JP., Choudhuri, R., Saito, K.., Subramanian, S., Mitchell, JB., and Krishna, MC. 2010 Low-Field Magnetic Resonance Imaging to Visualize Chronic and Cycling Hypoxia in Tumor-Bearing Mice. Cancer Research, 70:6427-6436
6) Jung SB, Kim CS, Naqvi A, Yamamori T, Mattagajasingh I, Hoffman T, Cole M, Kumar A, Dericco J, Jeon BH, Irani K. Histone Deacetylase-3 Antagonizes Aspirin-Stimulated Endothelial Nitric Oxide Production by Reversing Aspirin-Induced Lysine Acetylation of Endothelial Nitric Oxide Synthase. Circulation Research, 2010;107(7):877-87.
7) Naqvi A, Hoffman T, Dericco J, Kumar A, Kim CS, Jung SB, Yamamori T, Kim Y, Mehdi F, Kumar S, Rankinen T, Ravussin E, Irani K. A single nucleotide variation in a p53 binding site affects nutrient-sensitive human SIRT1 expression. Human Molecular Genetics, 2010; 19(21):4123-33 8) Matsumoto, S., Yasui, H., Mitchell, JB., and Krishna, MC. 2010.Imaging cycling tumor hypoxia.Cancer Research, 70:10019-10023
*Publications
1） Yasui, H., Yamamori. T., Meike, S., Eitaki, M., Iizuka, D., Kuwabara, M., and Inanami, O. 2010.New insight into hypoxia-targeting cancer therapy. Radiation Biology Research Communications, 45: 45-57. (in Japanese)
2) Yasui, H. 2010. Report of overseas research experience, Spin Science, 14: 51-53. (in Japanese)
