Studying a human inherited host-defense system, named innate immunity, that is conserved along human development, is a main theme in our laboratory. Immune responses secondary to caner and infections that induced by a number of microbes are a scope of our interest. The concrete subjects for our basic research and education are:１．Mechanisms of dendritic cell maturation in response to Toll-like receptor (TLR) agonists, 2.Host defense responses against viruses, particularly induced by DNA/RNA sensors, ３．Mechanisms by which antitumor effectors are raised, ４．Molecular evolution of the innate immune system. Our translational research involves 1. Development of tumor vaccines、2. Development of adjuvants for enhancing antitumor immunity、3. Establishment of immunotherapy for cancer. We have respected students' personality and sincerity for long-lasting human-to-human association. The most importance is to establish humanity based on one's trust and friendship nurtured through scientific investigation.

1. Promotion of fostering Zoonosis Control Expert
2. Support for career path activity

1. Oshiumi, H., M. Matsumoto, K. Funami, T. Akazawa, and T. Seya. 2003. TICAM-1, an adapter molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nature Immunol. 4: 161-167.
2. Akazawa T., M. Okuno, Y. Okuda, K. Tsujimura, T. Takahashi, M. Ikawa, M. Okabe, T. Ebihara, M, Shingai, N. Inoue, M. Tanaka-Okamoto, H. Ishizaki, J. Miyoshi, M. Matsumoto, and T. Seya. 2007. Antitumor NK activation induced by the Toll-like receptor3-TICAM-1 (TRIF) pathway in myeloid dendritic cells. Proc. Natl. Acad. Sci. USA. 104: 252-257.
3. Ebihara, T., M. Azuma, H. Oshiumi, J. Kasamatsu, K. Iwabuchi, K. Matsumoto, H. Saito, T. Taniguchi, M. Matsumoto, and T. Seya. 2010. Identification of a polyI:C-inducible membrane protein, that participates in dendritic cell-mediated natural killer cell activation. J. Exp. Med. 207: 2675-2687.
4. Oshiumi, H., M. Miyashita, N. Inoue, M. Okabe, M. Matsumoto, and T. Seya. 2010. Essential role of Riplet in RIG-I-dependent antiviral innate immune responses. Cell host microbe. 8: 496-509.
5. Shime H, M. Matsumoto, H. Oshiumi, S. Tanaka, A. Nakane, Y. Iwakura, H. Tahara, N. Inoue, and T. Seya. 2011. TLR3/TICAM-1 signaling converts tumor-supporting myeloid cells to tumoricidal effectors. Proc Natl Acad Sci USA. (in press).