We welcome any highly motivated student to apply for the Veterinary Science for One Health program from all over the world.
Osamu INANAMI
Affiliation：
Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University
Title：Professor
Degree：Doctor of Veterinary Medicine
Name of the field：Radiation Biology
Current research
We conduct the research about 1) the mechanism for radiation-induced cellular responses (i.e., cell death, apoptosis, cell arrest and mitochondrial metabolism) in normal and tumor tissue and their related signal transduction, 2) the development for the functional imaging technique in laboratory animals by employing magnetic resonance imaging (MRI) and positron emission tomography (PET) and 3) the structural analysis for high molecular weight biomolecules such as prion fibrous form by the site-directed spin labeling (SDSL) technique combined with electron spin resonance (ESR) spectroscopy.
Projects for graduate students
- Promotion of fostering Chemical Hazard Control Expert (Evaluations of radiation effect in biological system and radioactive contamination in food stuff).
Recent publications
- Meike, S., Yamamori, T., Yasui, H., Eitaki, M., Matsuda, A., Morimatsu, M., Fukushima, M., Yamasaki, Y. and Inanami, O. 2011. A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression. Mol. Cancer, 10:92.
- Ogura, A., Oowada, S., Kon, Y., Hirayama, A., Yasui, H., Meike, S., Kobayashi, S., Kuwabara, M. and Inanami, O. 2009. Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells. Cancer Lett., 277:64-71.
- Yasui, H., Ogura, A., Asanuma, T., Matsuda, A., Kashiwakura, I., Kuwabara, M. and Inanami, O. 2008. Inhibition of HIF-1alpha by the anticancer drug TAS106 enhances X-ray-induced apoptosis in vitro and in vivo. Br. J. Cancer, 99:1442-1452.
- Watanabe, Y., Hiraoka, W., Shimoyama, Y., Horiuchi, M., Kuwabara, M., Inanami, O. 2008. Instability of familial spongiform encephalopathy-related prion mutants. Biochem. Biophys. Res. Commun., 366:244-249.
- Asanuma, T., Doblas, S., Tesiram, Y.A., Saunders, D., Cranford, R., Yasui, H., Inanami, O., Smith, N., Floyd, R.A., Kotake, Y., Towner, R.A., 2008. Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography. J. Magn. Reson. Imaging., 28:574-587.
