Ecotoxicology, comparative animal physiology and toxicology. Research subjects are to clarify the effects of environmental pollution on the physiology of wildlife, and to elucidate metabolic pathways and signal cascades of xenobiotics in wild and laboratory animals.

1. Support for career path activity
2. Publicity activity for the program
3. Promotion of fostering Chemical Hazard Control Expert
4. Global surveillance for chemical hazard／Support for the international activity in the field of chemical hazard

1. Ohno, M., Darwish, W.S., Ikenaka, Y., Miki, W., Fujita, S., Ishizuka, M. 2011. Astaxanthin rich crude extract of Haematococcus pluvialis induces cytochrome P450 1A1 mRNA by activating aryl hydrocarbon receptor in rat hepatoma H4IIE cells. Food Chem. 130:356-361
2. Ueda, H., Ikenaka, Y., Nakayama, S.M., Tanaka-Ueno, T., Ishizuka, M. 2011. Phase-II conjugation ability for PAH metabolism in amphibians: Characteristics and inter-species differences. Aquat Toxicol. 105(3-4):337-343.
3. Nakayama, S.M.M., Ikenaka, Y., Hamada, K., Muzandu, K., Choongo, K., Teraoka, H., Mizuno, N., Ishizuka, M. 2011.Metal and metalloid contamination in roadside soil and wild rats around a Pb-Zn mine in Kabwe, Zambia. Environ Pollut. 159(1):175-81.
4. Watanabe, K.P., Saengtienchai, A., Tanaka, K.D., Ikenaka, Y., Ishizuka, M. 2010. Comparison of warfarin sensitivity between rat and bird species. Comp Biochem Physiol C Toxicol Pharmacol. 152(1):114-9.
5. Takiguchi, M., Darwish, W.S., Ikenaka, Y., Ohno, M., Ishizuka, M. 2010. Metabolic activation of heterocyclic amines and expression of CYP1A1 in the tongue. Toxicol Sci. Jul;116(1):79-91.