研究業績

業績：論文（2025年度）

1. Kawano K, Sakaguchi K, Ninpetch N, Frukawa E, Yanagawa Y, Katagiri S. Effects of heat stress on gene expression associated with antioxidant capacity of bovine early antral follicles. J Vet Med Sci 87, 680-684, 2025. https://doi.org/10.1292/jvms.25-0055.

2. Shimozuru M, Nakamura S, Yamazaki J, Yanagawa Y, Tamatani H, Kuroe M, Yamazaki K, Koike S, Goto Y, Naganuma T, Tochigi K, Inagaki A, Takekoshi N, Baek S, Sato N, Honda Y, Tsubota T, Ito H. Epigenetic Clock in Bears: A Simple Cost-Effective Blood DNA Methylation-Based Age Estimation Method Applicable to Multiple Bear Species. Ecol Evol 15, e71424,2025.https://doi.org/10.1002/ece3.71424.

3.Bai H, Saito Y, Nakajima H, Kawahara M, Yanagawa Y, Takahashi M, Miyazaki K. Exploring the Influence of Heat Stress on Gene Expression in Bovine Myeloid Cells In Vitro. Anim Sci J. 96, e70118,2025. https://doi.org/ 10.1111/asj.70118.

4. Nakamura S, Yamazaki J, Matsumoto N, Hagino K, Sakamoto H, Yamanaka M, Nakanishi M, Jimbo M, Yanagawa Y, Ito H, Tsubota T, Shimozuru M. Less-invasive age estimation using hair based on DNA methylation in brown bears. Sci Rep. 29, 45696, 2025. https://doi.org/10.1038/s41598-025-27455-2.

5. Bello TK, Tanida T, Tagami T, Yanagawa Y, Katagiri S. Effects of osteopontin treatment alone and in combination with hormonal therapy on endometrial epidermal growth factor concentration and fertility at the first insemination after calving in dairy cows. Theriogenology 254, 117812, 2026. https://doi.org/10.1016/j.theriogenology.2026.117812

6. Takekoshi N, Tomiyasu J, Yanagawa Y, Ohnishi N, Naganuma T, Baek SY, Itoh M, Luo X, Nishiwaki T, Kozakai C, Koike S, Yamazaki K. Relationship Between Testosterone and Movement Patterns in Male Asian Black Bear (Ursus thibetanus). Ecol Evol. 11, e72858, 2026. https://doi.org/10.1002/ece3.72858.


業績：論文（2024年度）

1. Kawano K, Sakaguchi K, Ninpetch N, Yanagawa Y, Katagiri S. Physiological high temperatures alter amino acid metabolism of bovine early antral follicles. J Reprod Dev 70, 184-191, 2024. https://doi.org/10.1262/jrd.2023-096.

2. Okuyama MW, Moriyoshi M, Katagiri S. Changes in interleukin-2, -4, -6 and -8 expression in the postovulatory sow endometrium after artificial insemination based on conceived or failed to conceive. J Reprod Dev 70, 192-196, 2024. https://doi.org/10.1262/jrd.2023-094.

3. Matsumoto N, Tomiyasu J, Hagino K, Matsui M, Yanagawa Y. Contraceptive effect of a gonadotropin-releasing hormone vaccine on captive male brown bears (Ursus arctos). Reprod Domest Anim 59, e14707, 2024. https://doi.org/10.1111/rda.14707.

4. Tanida T, Tagami T, Yanagawa Y, Katagiri S. Identification of an osteopontin structural element for the restoration of a normal endometrial epidermal growth factor (EGF) profile determined by the EGF concentration on day 3 of estrous cycle and pregnancy outcome in repeat breeder dairy cows. Theriogenology 231, 171-181, 2025. https://doi.org/10.1016/j.theriogenology.2024.10.013.


業績：論文（2023年度）

1. Yagisawa T, Uchiyama J, Takemura-Uchiyama I, Ando S, Ichii O, Murakami H, Matsushita O, Katagiri S. Metataxonomic analysis of the uterine microbiota associated with low fertility in dairy cows using endometrial tissues prior to first artificial insemination. Microbiol Spectr 11, e04764-22, 2023. https://doi.org/10.1128/spectrum.04764-22.

2. Furukawa E, Yanagawa Y, Matsuzaki A, Kim H, Bai H, Takahashi M, Katagiri S, Higaki S. Analysis of sequential ruminal temperature sensor data of dairy cows to identify cow subgroups by clustering and predict calving through supervised machine learning. J Reprod Dev 69, 103-108, 2023. https://doi.org/10.1262/jrd.2022-107.

3. Nakamura S, Yamazaki J, Matsumoto N, Inoue-Murayama M, Qi, H, Yamanaka M, Nakanishi M, Yanagawa Y, Sashika M, Tsubota T, Ito H, Shimozuru M. Age estimation based on blood DNA methylation levels in brown bears. Mol Ecol Resour 23, 1211-1225, 2023. https://doi.org/10.1111/1755-0998.13788.

4. Madalitso C, Yanagawa Y, Katagiri S, Nagano M. Pre-maturational culture promotes the developmental competence of bovine oocytes derived from an 8-day in vitro growth culture system. J Reprod Dev 69, 214-217, 2023. https://doi.org/10.1262/jrd.2023-022.

5. Kanno C, Sakamoto KQ, Kang S, Yanagawa Y, Katagiri S, Nagano M. The difference in subpopulation structures in sex-sorted and non-sorted semen by discriminant analysis of bull sperm motility data collected by a computer-assisted sperm analysis system. Andrologia 2023, 1-7, 2023. https://doi.org/10.1155/2023/9944344.
6. Phong VT, Fujikawa T, Kawano K, Yanagawa Y, Katagiri S. Effects of prostaglandin F2α treatment at follicular wave emergence on endometrial epidermal growth factor concentration on day 3 of the next estrous cycle and on fertility in dairy cows. Theriogenology 212, 189-196, 2023. https://doi.org/10.1016/j.theriogenology.2023.09.014.

7. Tanida T, Mukono I, Nakahashi M, Miyano D, Miyazawa K, Yanagawa Y, Katagiri S. The value of evaluating luteal blood flow on the day of embryo transfer for recipient selection in Holstein lactating dairy cows. Jpn J Vet Res 71, 72-81, 2024. https://doi.org/10.57494/jjvr.71.3_72.

8. Tanida T, Tagami T, Sato H, Kyaw HM, Fujikawa T, Nagano M, Momozawa K, Yanagawa Y, Katagiri S. Effects of recombinant osteopontin expressed in Escherichia coli on the recovery of the endometrial epidermal growth factor profile and fertility in repeat breeder dairy cows. Theriogenology 217, 159-168, 2024. https://doi.org/10.1016/j.theriogenology.2024.01.011.

 


業績：論文（2022年度）

1. Kawano K, Yanagawa Y, Nagano M, Katagiri S. Effects of heat stress on the endometrial epidermal growth factor profile and fertility in dairy cows. J Reprod Dev 68, 144-151, 2022. https://doi.org/10.1262/jrd.2021-120.

2. Ninpetch N, Badrakh D, Kyaw HM, Kawano K, Yanagawa Y, Nagano M, Katagiri S. Leptin receptor expression and its change in association with the normalization of EGF profile after seminal plasma treatment in repeat breeder dairy cows. J Reprod Dev 68, 209-215, 2022. https://doi.org/10.1262/jrd.2021-142.

3. Sakaguchi K, Kawano K, Yanagawa Y, Katagiri S, Nagano M. Effects of the presence of a large follicle and a corpus luteum in bovine ovaries on nuclear maturation of oocytes and steroidogenesis of granulosa cells cultured as oocyte-cumulus-granulosa complexes derived from early antral follicles. Jpn J Vet Res 70, 45-56, 2022. https://doi.org/10.14943/jjvr.70.2.45.

4. Kyaw HM, Sato H, Tagami T, Yanagawa Y, Nagano M, Katagiri S. Effects of milk osteopontin on the endometrial epidermal growth factor profile and restoration of fertility in repeat breeder dairy cows. Theriogenology 184, 26-33, 2022. https://doi.org/10.1016/j.theriogenology.2022.02.008.

5. Kawano K, Sakaguchi K, Madalitso C, Ninpetch N, Kobayashi S, Furukawa E, Yanagawa Y, Katagiri S. Effect of heat exposure on the growth and developmental competence of bovine oocytes derived from early antral follicles. Sci Rep 12, 8857, 2022. https://doi.org/10.1038/s41598-022-12785-2.

6. Furukawa E, Kanno C, Yanagawa Y, Katagiri S, Nagano M. Relationship between the timing of insemination based on estrus detected by the automatic activity monitoring system and conception rates using sex-sorted semen in Holstein dairy cattle. J Reprod Dev 68, 295-298, 2022. https://doi.org/10.1262/jrd.2022-006.

7. Saito S, Akizawa H, Furukawa E, Yanagawa Y, Bai H, Takahashi M, Kawahara M. Generation of viable calves derived from developmentally mature blastocysts produced by on-gel culture. J Reprod Dev 68, 330-334, 2022. https://doi.org/10.1262/jrd.2022-054.

8. Furukawa E, Chen Z, Kubo T, Wu Y, Ueda K, Chelenga M, Chiba H, Yanagawa Y, Katagiri S, Nagano M, Hui SP. Simultaneous free fatty acid elevations and accelerated desaturation in plasma and oocytes in early postpartum dairy cows under intensive feeding management. Theriogenology 193, 20-29, 2022. https://doi.org/10.1016/j.theriogenology.2022.09.006.

9. Kanno C, Kang SS, Sakamoto KQ, Yanagawa Y, Katagiri S, Nagano M. Relationship between frame rates and subpopulation structure of bovine sperm divided by their motility analyzed by a computer-assisted sperm analysis system. Anim Sci J 93, e13796, 2022. https://doi.org/10.1111/asj.13796.

10. Sakaguchi K, Kawano K, Otani Y, Yanagawa Y, Katagiri S, Telfer EE. Relationship between amino acid metabolism and bovine in vitro follicle activation and growth. Animals 13, 1141, 2023. https://doi.org/10.3390/ani13071141.


業績：論文（2021年度）

1. Ganbaatar O, Konnai S, Okagawa T, Nojima Y, Maekawa N, Ichikkawa Y, Kobayashi A, Shibahara T, Yanagawa Y, Higuchi H, Kato Y, Suzuki Y, Murata S, Ohashi K. Programmed death-ligand 1 expression in swine chronic infections and enhancement of interleukin-2 production via programmed death-1/programmed death-ligand 1 blockade. Immun Inflamm Dis, 9: 1573-1583, 2021. https://doi.org/10.1002/iid3.510.

2. Akizawa H, Saito S, Kohri N, Furukawa E, Hayashi Y, Bai H, Nagano M, Yanagawa Y, Tsukahara H, Takahashi M, Kagawa S, Kawahara-Miki R, Kobayashi H, Kono T, Kawahara M. Deciphering two rounds of cell lineage segregations during bovine preimplantation development. FASEB J 35: e21904, 2021. https://doi.org/10.1096/fj.202002762RR.

3.Furukawa E, Chen Z, Ueshiba H, Wu Y, Chiba H, Yanagawa Y, Katagiri S, Nagano M, Hui SP. Postpartum cows showed high oocyte triacylglycerols concurrently with high plasma free fatty acids. Theriogenology 176: 174-182, 2021. https://doi.org/10.1016/j.theriogenology.2021.09.034.

4. Madalitso C, Sakaguchi K, Kawano K, Furukawa E, Yanagawa Y, Katagiri S, Nagano M. Low oxygen environment and astaxanthin supplementation promote the developmental competence of bovine oocytes derived from early antral follicles during 8 days of in vitro growth in a gas-permeable culture device. Theriogenology 177: 116-126, 2022. https://doi.org/10.1016/j.theriogenology.2021.10.014.

5. Takaesu N, Minami M*, NaganoM, Kaneko A, Indo Y, Imai H, Hirai H, Sashika M, Shimozuru M, Okamoto M, Katagiri S, Tsubota T, Yanagawa Y. Ovulatory follicle size investigated by ultrasonography and single artificial insemination with ovulation induction in the Japanese macaque (Macaca fuscata). Jpn J Vet Res 70: 5-17, 2022. https://doi.org/10.14943/jjvr.70.1.5.

6. Takaesu N, Kanno C*, Sugimoto K, Nagano M, Kaneko A, Indo Y, Imai H, Hirai H, Okamoto M, Sashika M, Shimozuru M, Katagiri S, Tsubota T, Yanagawa Y “Semen collection by urethral catheterization and electro-ejaculation with different voltage, and effect of holding temperature and cooling rate before cryopreservation on semen quality in the Japanese macaque (Macaca fuscata). J Vet Med Sci 84: 429-438, 2022. https://doi.org/10.1292/jvms.21-0590.

7. Sakaguchi K, Suda T, Ninpetch, Kawano K, Yanagawa Y, Katagiri S, Yoshioka K, Nagano M. Plasma profile of follicle-stimulating hormone and sex steroid hormones after a single epidural administration of follicle-stimulating hormone via caudal vertebrae in Holstein dry cows. Anim Sce J 93: e13696, 2022. https://doi.org/10.1111/asj.13696.

8. Azumano A, Ueda M, Nomura M, Usui M, Ichinose M, Yanagawa Y, Kusuda S, Matsumoto Y, Murata K. Successful laparoscopic oviductal artificial insemination in the endangered Tsushima leopard cat (Prionailurus bengalensis euptilurus). Animals 12: 777, 2022. https://doi.org/10.3390/ani12060777.


業績：論文（2020年度）

1. Badrakh D, Shirasawa A, Yanagawa Y, Nagano M, Katagiri S. Identification of bovine seminal plasma proteins with an activity to normalize endometrial epidermal growth factor concentrations in repeat breeder cows. Japanese Journal of Veterinary Research. 68: 91-103, 2020.　 http://doi.org/10.14943/jjvr.68.2.91.

2. Chelenga M, Sakaguchi K, Abdel-Ghani MA, Yanagawa Y, Katagiri S, Nagano M. Effect of increased oxygen availability and astaxanthin supplementation on the growth, maturation and developmental competence of bovine oocytes derived from early antral follicles. Theriogenology. 157: 341-349, 2020. https://doi.org/10.1016/j.theriogenology.2020.07.023.

3. Jimbo M, Matsumoto N, Sakamoto H, Yanagawa Y, Torii Y, Yamanaka M, Ishinazaka T, Shirane Y, Sashika M, Tsubota T, Shimozuru M. Hair growth in brown bears and its application to ecological studies on wild bears. Mammal Study. 66: 563-570, 2020. https://doi.org/10.3106/ms2020-0021.

4. Torii Y, Matsumoto N, Sakamoto H, Nagano M, Katagiri S, Yanagawa Y. Monitoring follicular dynamics to determine estrus type and timing of ovulation induction in captive brown bears (Ursus arctos). Journal of Reproduction and Development. 66: 563-570, 2020. https://doi.org/10.1262/jrd.2020-044.

5. Bai H, Ukita H, Kawahara M, Mitani T, Furukawa E, Yanagawa Y, Yabuuchi N, Kim H, Takahashi M. Effect of summer heat stress on gene expression in bovine uterine endometrial tissues. Animal Science Journal. 91: e13474, 2020. https://doi.org/10.1111/asj.13474.

6. Sato H, Hiraya H, Sugiyama T, Fukumoto S, Matsuyama R, Yanagawa Y, Nakao R, Irie T, Taira K, Yamazaki A, Hagiwara K, Yoshida A, Kamata Y, Ichikawa-Seki M. Seroprevalence of fasciolosis in Hokkaido sika deer (Cervus nippon yesoensis) from Hokkaido Prefecture, Japan revealed by ELISA using recombinant cathepsin L1. Parasitology International. 80: 102222, 2021. https://doi.org/10.1016/j.parint.2020.102222.

7. Hashimoto M, Kimura S, Kanno C, Yanagawa Y, Watanabe T, Okabe J, Takahashi E, NaganoM, Kitamura H. Macrophage ubiquitin-specific protease 2 contributes to motility, hyperactivation, capacitation, and invitro fertilization activity of mouse sperm. Cellular and Molecular Life Science. 78: 2929-2948, 2021. https://doi.org/10.1007/s00018-020-03683-9.