北海道大学大学院獣医学研究院獣医学部 先端獣医療学教室（附属動物病院）

PUBLICATIONS / 業績

1. Yoshida S, Sugawara-Suda M, Sasaoka K, Sasaki N, Yokoyama N, Nakamura K, Morishita K, Kim S, Sunaga T, Takiguchi M. Evaluation of the course of improvement with molnupiravir treatment for feline infectious peritonitis. Can Vet J. 66(5), 546?554, 2025. PMC12044628 (available on 2025-08-01)
2. Kawamoto S, Nakamura K, Mori T, Wada T, Fujiwara A, Takiguchi M. Pre-operative left atrial size and functions are predictors of left atrial reverse remodelling after mitral valvuloplasty for myxomatous mitral valve disease in dogs. J Vet Cardiol 57, 47-57, 2025
3. Owaki R, Hosoya K, Deguchi T, Konnai S, Maekawa N, Okagawa T, Yasui H, Kim S, Sunaga T, Okumura M. Enhancement of radio-sensitivity by inhibition of Janus kinase signaling with oclacitinib in canine tumor cell lines. Mol Ther oncol. 33:200946,2025
4. Matsumoto S, Hosoya K, Kim S, Okumura M. Tensioning diaphragmoplasty for treating bilateral phrenic nerve paralysis in a dog. J Small Anim Pract doi: 10.1111/jsap.13836. 2025
5. Maekawa N, Konnai S, Watari K, Takeuchi H, Nakanishi T, Tachibana T, Hosoya K, Kim S, Kinoshita R, Owaki R, Yokokawa M, Kagawa Y, Takagi S, Deguchi T, Ohta H, Kato Y, Yamamoto S, Yamamoto K, Suzuki Y, Okagawa T, Murata S, Ohashi K. Development of caninized anti-CTLA-4 antibody as salvage combination therapy for anti-PD-L1 refractory tumors in dogs. Front Immunol. 2025 May 20;16:1570717. doi: 10.3389/fimmu.2025.
6. Sung K, Hosoya K, Deguchi T, Yamashita K, Kim S, Sunaga T, Yasui H, Inanami O, Okumura M. Glutathione-associated redox regulation alleviates radio-resistance of canine cancer stem-like cells with low proteasome activity. Sci Rep. 2025 May 23;15(1):18017. doi: 10.1038/s41598-025-02569-9.

1. Ming KM, Le Verger K, Geiger M, Schmelzle T, Georgalis GL, Shimbo G, Sasaki M, Ohdachi SD, Sanchez-Villagra MR. Insular dwarfism in horses from the Aegean Sea and the Japanese archipelago. Mammalian Biology, Volume104 345-361,2024.
2. Sasaoka K, Sato T, Morishita K, Hosoya K, Yokoyama N, Sato T, Horiuchi M, Takiguchi M. Antimicrobial resistance and self-reported hand hygiene awareness before and after an infection prevention and control programme: a 7-year analysis in a small animal veterinary teaching hospital. Vet J 306, 106154, 2024.
3. Kida I, Hayashi N, Yokoyama N, Nagata N, Sasaoka K, Sasaki N, Morishita K, Nakamura K, Kouguchi H, Yagi K, Nakao R, Takiguchi M, Nonaka N. Case report: Echinococcus multilocularis infection in a dog showing gastrointestinal signs in Hokkaido, Japan. Front Vet Sci 11, 1373035, 2024.

1. 田川 道人, 新坊 弦也, 富張 瑞樹, 宮原 和郎：常電圧放射線発生装置を用いて治療した口腔内悪性黒色腫の犬の17症例, 日本獣医師会雑誌 76 (3), e55-e61, 2023.
2. Deguchi T, Maekawa N, Konnai S, Owaki R, Hosoya K, Morishita K, Nakamura M, Okagawa T, Takeuchi H, Kim S, Kinoshita R, Tachibana Y, Yokokawa M, Takagi S, Kato Y, Suzuki Y, Murata S, Ohashi K. Enhanced Systemic Antitumour Immunity by Hypofractionated Radiotherapy and Anti-PD-L1 Therapy in Dogs with Pulmonary Metastatic Oral Malignant Melanoma. Cancers (Basel) 15(11), 3013, 2023.
3. Tamura J, Yoshida S, Nagata N, Shimbo G, Oyama N. Successful treatment of acute respiratory failure following hypertensive crisis in a dog with presumed pheochromocytoma or paraganglioma. Open Vet J 13(11), 1465-1470, 2023.
4. 田村純, 大山紀彦, 三木伸悟, 中村健介, 木之下怜平, 奥村正裕. 大動脈弁逆流と左室流出路狭窄が併発した犬に対して観血的動脈血圧測定を行い術中循環管理を実施した一例. 日本獣医麻酔外科雑誌, 54(1), 15-22, 2023.
5. Yokoyama N, Kinoshita R, Ohta H, Okada K, Shimbo G, Sasaoka K, Nagata N, Sasaki N, Morishita K, Nakamura K, Kagawa Y, Takiguchi M. Successful treatment of sclerosing encapsulating peritonitis in a cat using bioresorbable hyaluronate-carboxymethylcellulose membrane after surgical adhesiolysis and long-term prednisolone. JFMS Open Rep 24, 20551169231209917, 2023.
6. 田川 道人, 新坊 弦也, 富張 瑞樹, 渡邉 謙一, 古林 与志安: 転移病変に対しリン酸トセラニブの投与を行った組織球性肉腫の犬の1症例. 日本獣医師会雑誌 76, 8, e202-e207, 2023.
7. Sugawara-Suda M, Morishita K, Ichii O, Namba T, Aoshima K, Kagawa Y, Kim S, Hosoya K, Yokoyama N, Sasaki N, Nakamura K, Yamazaki J, Takiguchi M. Transcriptome and proteome analysis of dogs with precursor targeted immune-mediated anemia treated with splenectomy. PLoS One 5, 18(5), e0285415, 2023.
8. Sugawara-Suda M, Morishita K, Iwanaga Y, Yamazaki J, Kagawa Y, Yokoyama N, Sasaki N, Ohta H, Nakamura K, Takiguchi M. Investigation of the therapeutic effects, predictors, and complications of long-term immunosuppressive therapy in dogs with precursor-targeted immune-mediated anemia. J Vet Med Sci 1, 85(7), 695-701, 2023.
9. Maekawa N, Konnai S, Hosoya K, Kim S, Kinoshita R, Deguchi T, Owaki R, Tachibana Y, Yokokawa M, Takeuchi H, Kagawa Y, Takagi S, Ohta H, Kato Y, Yamamoto S, Yamamoto K, Suzuki Y, Okagawa T, Murata S, Ohashi K. Safety and clinical efficacy of an anti-PD-L1 antibody (c4G12) in dogs with advanced malignant tumours. PLoS One. 2023 Oct 4;18(10):e0291727. doi: 10.1371/journal.pone.0291727.
10. Asari Y, Yamazaki J, Thandar O, Suzuki T, Aoshima K, Takeuchi K, Kinoshita R, Kim S, Hosoya K, Ishizaki T, Kagawa Y, Jelinek J, Yokoyama S, Sasaki N, Ohta H, Nakamura K, Takiguchi M. Diverse genome-wide DNA methylation alterations in canine hepatocellular tumours. Vet Med Sci. 2023 Sep;9(5):2006-2014. doi: 10.1002/vms3.1204.
11. Kanemoto H, Fujiwara-Igarashi A, Kobayashi T, Harada K, Ichimata M, Kim S, Hosoya K, Tomiyasu H, Ohmi A, Tsujimoto H. Retrospective study of feline tracheal mass lesions. J Feline Med Surg. 2023 May;25(5):1098612X231164611. doi: 10.1177/1098612X231164611.
12. Owaki R, Deguchi T, Konnai S, Maekawa N, Okagawa T, Hosoya K, Kim S, Sunaga T, Okumura M. Regulation of programmed death ligand 1 expression by interferon-γ and tumour necrosis factor-α in canine tumour cell lines. Vet Comp Oncol. 2023 Jun;21(2):279-290. doi: 10.1111/vco.12886.

1. Hoshi K, Hosoya K, Takagi S, Okumura M. Direct renal pelvicocystostomy using tube cystoplasty in a cat with ureteral obstruction. J Small Anim Pract. 2022:63:635-641.
2. Sasaoka K, Ohta H, Ishizuka T, Osuga T, Morishita K, Sasaki N, Takiguchi M. Local cerebral blood flow assessment using transcranial Doppler ultrasonography in a dog with brain infarction in the right middle cerebral artery territory. J Vet Med Sci 84, 1385-1390, 2022.
3. Sasaoka K, Ohta H, Ishizuka T, Kojima K, Sasaki N, Takiguchi M. Transcranial Doppler ultrasonography detects the elevation of cerebral blood flow during ictal-phase of pentetrazol-induced seizures in dogs. Am J Vet Res 83, 331?338, 2022.
4. Nagata N, Sawamura H, Morishita K, Hosoya K, Yokoyama N, Sasaoka K, Sasaki N, Nakamura K, Ikenaka Y, Takiguchi M. Urinary corticoid to creatinine ratios using IMMULITE 2000 XPi for diagnosis of canine hypercortisolism. J Vet Med Sci 84, 954-959, 2022.
5. Oo T, Sasaki N, Ikenaka Y, Ichise T, Nagata N, Yokoyama N, Sasaoka K, Morishita K, Nakamura K, Takiguchi M. Serum steroid profiling of hepatocellular carcinoma associated with hyperadrenocorticism in dogs: A preliminary study. Front Vet Sci 28, 9:1014792, 2022.
6. El-Hawari SF, Oyama N, Koyama Y, Tamura J, Itami T, Sano T, Yamashita K. Sparing effect of tramadol, lidocaine, dexmedetomidine and their combination on the minimum alveolar concentration of sevoflurane in dogs. J Vet Sci 23, e53, 2022.
7. Maekawa N, Konnai S, Asano Y, Sajiki Y, Deguchi T, Okagawa T, Watari K, Takeuchi H, Takagi S, Hosoya K, Kim S, Ohta H, Kato Y, Suzuki Y, Murata S, Ohashi K. Exploration of serum biomarkers in dogs with malignant melanoma receiving anti-PD-L1 therapy and potential of COX-2 inhibition for combination therapy. Sci Rep. 2022 Jun 3;12(1):9265. doi: 10.1038/s41598-022-13484-8.
8. Gulay KCM, Aoshima K, Kim S, Kitaguchi R, Kobayashi A, Kimura T. The expression of histone lysine demethylase 2B in canine hemangiosarcoma is associated with disease progression. Vet Comp Oncol. 2022 Jun;20(2):529-534. doi: 10.1111/vco.12796.

1. Suzuki T, Hirai A, Khidkhan K, Nimako C, Ichise T, Takeda K, Mizukawa H, Nakayama SMM, Nomiyama K, Hoshi N, Maeda M, Hirano T, Sasaoka K, Sasaki N, Takiguchi M, Ishizuka M, Ikenaka Y. The effects of fipronil on emotional and cognitive behaviors in mammals. Pestic Biochem Physiol. 175, 104847, 2021.
2. Ichikawa Y, Heishima M, Vyhnal K, Aoshima K, Sasaoka K, Kinoshita R, Kobayashi A, Takiguchi M, Kimura T. Systemic mucoid degeneration of the arterial tunica intima in a young dog. J Vet Diagn Invest. 34(1), 94?97, 2021.
3. Sasaki N, Oo T, Yasuda Y, Ichise T, Nagata N, Yokoyama N, Sasaoka K, Morishita K, Nakayama SM, Ishizuka M, Nakamura K, Takiguchi M, Ikenaka Y. Simultaneous steroids measurement in dogs with hyperadrenocorticism using a column-switching liquid chromatography-tandem mass spectrometry method. J Vet Med Sci.83(11), 1634?1642, 2021.
4. Osuga T, Morita T, Sasaki N, Morishita K, Ohta H, Takiguchi M. Echocardiographic estimation of left ventricular-arterial coupling in dogs with myxomatous mitral valve disease.J Vet Intern Med, 35(1), 78-87, 2021.
5. Tamura M, Ohta H, Osuga T, Sasaki N, Morishita K, Takiguchi M. Extrahepatic biliary obstruction can interfere with hepatic fibrosis prediction using two-dimensional shear wave elastography in dogs. Vet Radiol Ultrasound, 62(4), 483-489, 2021.
6. Osuga T, Morita T, Sasaki N, Morishita K, Ohta H, Takiguchi M. Prognostic value of left ventricular-arterial coupling estimated using echocardiography in dogs with myxomatous mitral valve disease. J Vet Intern Med, 35(6), 2607-2615, 2021.
7. Tagawa M, Shimbo G, Uemura A, Matsumoto K. Cardiomyopathy in a dog with multicentric lymphoma following treatment with several anthracyclines. Open Vet J, 11(1):6-10, 2021.
8. Leela-Arporn R, Ohta H, Shimbo G, Sasaki N, Takiguchi M. Morphometric evaluation of canine hepatocellular carcinoma using computed tomography: a promising tool for predicting malignancy. J Vet Med Sci, 83(9):1459-1464, 2021
9. Shimbo G, Takiguchi M. CT morphology of anomalous systemic arterial supply to normal lung in dogs. Vet Radiol Ultrasound, 62(6):657-665, 2021.
10. Tagawa M, Shimbo G, Miyahara K. Prognostic role of lymphocyte to monocyte ratio in feline high-grade lymphomas. Can Vet J, 62(10):1095-1103, 2021.
11. Shimbo G, Echigo R, Takiguchi M. The use of 4-dimensional magnetic resonance angiography as a noninvasive procedure to diagnose subclavian steal syndrome in a dog. J Am Vet Med Assoc, 259(9):1040-1042, 2021.
12. Nagahara T, Ohno K, Nagao I, Nakagawa T, Yokoyama N, Ohmi A, Goto-Koshino Y, Chambers JK, Uchida K, Tomiyasu H, Tsujimoto H. Changes in the coagulation parameters in dogs with protein-losing enteropathy between before and after treatment. J Vet Med Sci 83, 1295?1302, 2021.
13. Deguchi T, Hosoya K, Kim S, Murase S, Yamamoto K, Bo T, Yasui H, Inanami O, Okumura M. Metformin preferentially enhances the radiosensitivity of cancer stem-like cells with highly mitochondrial respiration ability in HMPOS. Molecular Therapy- Oncolytics, 2021; 22:143-151,2021.
14. Gulay KCM, Nagata N, Aoshima K, Shiohara N, Kobayashi A, Takiguchi M, Kimura T. Peliosis hepatis with chylous ascites in a dog. J Comp Pathol, 187:63-67, 2021.

1. Adachi M, Hoshino Y, Izumi Y, Sakai H, Takagi S. Effects of inhibitors of vascular endothelial growth factor receptor 2 and downstream pathways of receptor tyrosine kinases involving phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin or mitogen-activated protein kinase in canine hemangiosarcoma cell lines. Can J Vet Res, 80(3):209-16, 2016,
2. Adachi M, Hoshino Y, Izumi Y, Takagi S. Immunohistochemical detection of a potential molecular therapeutic target for canine hemangiosarcoma. J Vet Med Sci, 3;78(4):649-56, 2016,
3. Itami T, Endo Y, Hanazono K, Ishizuka T, Tamura J, Miyoshi K, Sano T, Yamashita K. Comparison of cardiac output measurements using transpulmonary thermodilution and conventional thermodilution techniques in anaesthetized dogs with fluid overload. Vet Anaesth Analg, 43(4): 388-396, 2016.
4. Itami T, Saito Y, Ishizuka T, Tamura J, Umar MA, Inoue H, Miyoshi K, Yamashita K. Comparison of pharmacokinetics of tramadol between young and middle-aged dogs. J Vet Med Sci, 78(6): 1031-1034, 2016.
5. Kagawa Y, Nakano Y, Kobayashi T, Asano K, Takagi S. Localized pulmonary histiocytic sarcomas in Pembroke Welsh Corgi. J Vet Med Sci, 77(12):1659-61, 2016.
6. Maekawa N, Konnai S, Okagawa T, Nishimori A, Ikebuchi R, Izumi Y, Takagi S, Kagawa Y, Nakajima C, Suzuki Y, Kato Y, Murata S, Ohashi K. Immunohistochemical Analysis of PD-L1 Expression in Canine Malignant Cancers and PD-1 Expression on Lymphocytes in Canine Oral Melanoma. PLoS One, 8;11(6):e0157176, 2016.
7. Morita T, Nakamura K, Osuga T, Lim S, Y, Yokoyama N, Morishita, K, Ohta H, and Takiguchi M. Repeatability and reproducibility of right ventricular Tei index valves derived from three echocardiographic methods for evaluation of cardiac function in dogs. Am. J. Vet. Res, 77: 715?720, 2016.
8. Osuga, T, Nakamura, K, Morita T, Nisa K, Yokoyama N, Sasaki N, Morishita, K, Ohta, H, and Takiguchi M. Effects of experimental cardiac volume loading on left atrial phasic function in healthy dogs. Am. J. Vet. Res, 77: 952?960, 2016.
9. Tagawa M, Maekawa N, Konnai S, Takagi S. Evaluation of Costimulatory Molecules in Peripheral Blood Lymphocytes of Canine Patients with Histiocytic Sarcoma. PLoS One. 22;11(2):e0150030, 2016.
10. Tamura J, Hatakeyama N, Ishizuka T, Itami T, Fukui S, Miyoshi K, Sano T, Pasloske K, Yamashita K. The pharmacological effects of intramuscular administration of alfaxalone combined with medetomidine and butorphanol in dogs. J Vet Med Sci, 78(6): 929-936, 2016.
11. 華園 究, 福本 真也, 小川 雄基, 吉田 智彦, 吉田 慧, 岩野 英知, 宮庄 拓, 打出 毅. 三尖弁逆流を伴う僧帽弁閉鎖不全症の犬の血清Big Endothelin-1 濃度による肺高血圧症検出の試み,動物の循環器,49: 1-9, 2016.
12. Endo Y, Tamura J, Ishizuka T, Itami T, Hanazono K, Miyoshi K, Sano T, Yamashita K, Muir WW. Stroke volume variation (SVV) and pulse pressure variation (PPV) as indicators of fluid responsiveness in sevoflurane anesthetized mechanically ventilated euvolemic dogs. J Vet Med Sci, 79(8): 1437-1445, 2017.
13. Fukui S, Ooyama N, Tamura J, Umar MA, Ishizuka T, Itami T, Miyoshi K, Sano T, Yamashita K. Interaction between maropitant and carprofen on sparing of the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs. J Vet Med Sci, 79(3): 502-508, 2017.
14. Ichii O, Ohta H, Horino T, Nakamura T, Hosotani M, Mizoguchi T, Morishita K, Nakamura K, Hoshino Y, Takagi S, Sasaki N, Takiguchi M, Sato R, Oyamada K, Kon Y. Urinary exosome-derived microRNAs reflecting the changes of renal function and histopathology in dogs. Sci Rep, 11(7): 40340, 2017
15. Itami T, Aida H, Asakawa M, Fujii Y, Iizuka T, Imai A, Iseri T, Ishizuka T, Kakishima K, Kamata M, Miyabe-Nishiwaki T, Nagahama S, Naganobu K, Nishimura R, Okano S, Sano T, Yamashita K, Yamaya Y, Yanagawa M. Association between preoperative characteristics and risk of anaesthesia-related death in dogs in small-animal referral hospitals in Japan. Vet Anaesth Analg, 44(3): 461-472, 2017.
16. Izumi Y, Aoshima K, Hoshino Y, Takagi S. Effects of combretastatin A-4 phosphate on canine normal and tumor tissue-derived endothelial cells. Res Vet Sci, 112:222-228, 2017.
17. Maekawa N, Konnai S, Takagi S, Kagawa Y, Okagawa T, Nishimori A, Ikebuchi R, Izumi Y, Deguchi T, Nakajima C, Kato Y, Yamamoto K, Uemura H, Suzuki Y, Murata S, Ohashi K. A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma. Sci Rep, 21;7(1):8951, 2017.
18. Matsuyama A, Takagi S, Hosoya K, Kagawa Y, Nakamura K, Deguchi T, Takiguchi M. Impact of surgical margins on survival of 37 dogs with massive hepatocellular carcinoma. N Z Vet J, 65(5):227-231, 2017.
19. Morishita, K, Hiramoto A, Michishita A, Takagi S, Hoshino, Y Itami, T Lim S. Y, Osuga T, Nakamura S, Ochiai K, Nakamura, K, Ohta H, Yamasaki M, and Takiguchi M. Assessment of contrast-enhanced ultrasonography of the hepatic vein for detection of hemodynamic changes associated with experimentally induced portal hypertension in dogs. Am. J. Vet, Res.78: 465?471, 2017.
20. Morishita, K Hiramoto, A Michishita, A, Takagi S, Osuga T, Lim S. Y, Nakamura K, Sasaki N, Ohta H, and Takiguchi M. Wash-out ratio in the hepatic vein measured by contrast-enhanced ultrasonography can distinguish between inflammatory and non-inflammatory hepatic disorders in dogs. J. Vet. Intern. Med, 31: 770?777, 2017.
21. Morishita K, Hiramoto A., Osuga T, Lim S. Y, Khoirun, N Sasaki, N Nakamura, K Ohta, H Yamasaki, M and Takiguchi M. Contrast-enhanced ultrasonography of the hepatic vein in normal dogs. J. Vet. Med, Sci.78: 1753?1758, 2017.
22. Morita T, Nakamura K, Osuga T, Yokoyama N, Khoirun N, Morishita K, Sasaki N, Ohta H, and Takiguchi M.The repeatability and characteristics of right ventricular longitudinal strain imaging by speckle tracking echocardiography in healthy dogs. J. Vet. Cardiol, 19: 351-362, 2017.
23. Morita T, Nakamura, K, Osuga T, Yokoyama N, Morishita K, Sasaki N, Ohta H, and Takiguchi M.Changes in right ventricular function assessed by echocardiography in dog models of mild RV pressure overload. Echocardiography, 34: 1040-1049, 2017.
24. Nakamura, K, Kawamoto S, Osuga T, Morita T, Sasaki N, Morishita, K Ohta, H, and Takiguchi, M.Left atrial strain at different stages of myxomatous mitral valve disease in dogs. J. Vet. Intern. Med, 31: 316?325, 2017.
25. Nisa K, Lim S. Y, Shinohara M, Nagata N, Sasaoka K, Dermlim A, Leela-Arporn R, Morita, T, Yokoyama, N, Osuga T, Sasaki N, Morishita K, Nakamura K, Ohta, H., and Takiguchi, M.Repeatability and reproducibility of quantitative contrast-enhanced ultrasonography for assessing duodenal perfusion in healthy dogs. J. Vet. Med. Sci, 79:1585-1590, 2017.
26. Ohta H, Morita T, Yokoyama N, Osuga T, Sasaki N, Morishita K, Nakamura K, and Takiguchi M. Serial measurement of pancreatic lipase immunoreactivity concentration in dogs with immune-mediated disease treated with prednisolone. J. Small Anim. Pract, 58: 342?347, 2017.
27. Osuga, T, Nakamura K, Morita T, Kagawa Y,Ohta H, and Takiguchi M.Diastolic heart failure associated with hemangiosarcoma infiltrating left ventricular walls in a dog.Can. Vet. J, 58: 1167?1170, 2017.
28. Osuga T, Nakamura, K, Morita, T, Watanabe K, and Takiguchi M.Veterinary Medicine Today: ECG of the Month .J. Am. Vet. Med. Assoc, 2017.
29. Sasaki N, Ishi K, Kudo N, Nakayama SMM, Nakamura K, Morishita K, Ohta H, Ishizuka M, Takiguchi M.Spatial and temporal profile of cisplatin delivery by ultrasound-assisted intravesical chemotherapy in a bladder cancer model. Plos One, 12(11):e0188093, 2017.
30. Sasaoka K, Nakamura K, Osuga, T, Morita T, Yokoyama N, Morishita K, Sasaki N, Ohta H, and Takiguchi M. Transcranial Doppler ultrasound examination in dogs with suspected intracranial hypertension caused by neurologic diseases. J. Vet. Intern. Med, 32: 314-323, 2017.
31. Yokoyama N, Ohta H, Kagawa, Y, Leela-Arporn, R, Dermlim A, Nisa K, Morita T, Osuga T, Sasaki N, Morishita K, Nakamura K, and Takiguchi M.Expression of apical junction complex proteins in colorectal mucosa of miniature dachshunds with inflammatory colorectal polyps. J. Vet. Med. Sci. 79: 456?463, 2017.
32. Yokoyama N, Ohta H, Kagawa Y, Nagata N, Nisa K, Morita T, Osuga T, Sasaki N, Morishita K, Nakamura K, and Takiguchi M.Stimulation of colorectal biopsies from miniature dachshunds with inflammatory colorectal polyps with toll-like receptor ligands: A pilot study.Vet. Immunol. Immunopathol, 188: 78?83, 2017.
33. Yokoyama N, Ohta H, Yamazaki J, Kagawa Y, Ichii O, Khoirun N, Morita T, Osuga T, Lim S. Y, Sasaki N, Morishita K, Nakamura K, amd Takiguchi M.Localization of Toll-like receptor (TLR) 2 and TLR4 mRNA in the colorectal mucosa of miniature dachshunds with inflammatory colorectal polyps. J. Comp. Pathol, 156: 183?190, 2017.
34. Fujita Y, Hanazono K, Uchida E, Kawahata T, Suto A, Nakamura K, Shimizu H.Renal failure in dogs kept by a man with severe psoriasis. J Eur Acad Dermatol Venereol, 31(4):e184-e185,2017.
35. Echigo R, Fujita A, Nishimura R, Mochizuki M.Triceps brachii tendon injury in four Pomeranians. J Vet Med Sci, 18;80(5):772-777, 2018.
36. Takaguchi K, Nishikawa H, Mizukawa H,Tanoue R,Yokoyama N, Ichii, O, Takiguchi M, Nakayama S.M.M, Ikenaka Y, Kunisue T, Ishizuka M,Tanabe S,Iwata H,Nomiyama K.Effects of PCB exposure on serum thyroid hormone levels in dogs and cats. Sci Total Environ, 688: 1172-1183, 2019.
37. Nakazawa M, Maeda S, Yokoyama N, Nakagawa T, Yonezawa T, Ohno K, Matsuki N.Sphingosine-1-phosphate (S1P) signaling regulates the production of intestinal IgA and its potential role in the pathogenesis of canine inflammatory bowel disease. J Vet Med Sci, 81(9): 1249-1258, 2019
38. Khidkhan K, Mizukawa H, Ikenaka Y, Nakayama SMM, Nomiyama K, Yokoyama N, Ichii O, Darwish WS, Takiguchi M, Tanabe S, Ishizuka M.Tissue distribution and characterization of feline cytochrome P450 genes related to polychlorinated biphenyl exposure. Comp Biochem Physiol C Toxicol Pharmacol, CBP 226 108613, 2019.
39. Ohara Y, Yabuki A, Nakamura R, Ichii O, Mizukawa H, Yokoyama N, Yamato O. Renal Infiltration of Macrophages in Canine and Feline Chronic Kidney Disease. J Comp Pathol, 170: 53-59, 2019.
40. Deguchi T, Hosoya K, Murase Y, Koangyong S, Kim S, Okumura M.Analysis of radiosensitivity of cancer stem-like cells derived from canine cancer cell lines. Vet Comp Oncol, 17(2):119-129, 2019.
41. Tamura M, Ohta H, Nisa K, Osuga T, Sasaki N, Morishita K, Takiguchi M.Contrast-enhanced ultrasonography is a feasible technique for quantifying hepatic microvascular perfusion in dogs with extrahepatic congenital portosystemic shunts. Vet Radiol Ultrasound, 60(2):192-200, 2019.
42. Morita T, Nakamura K, Osuga T, Yokoyama N, Morishita K, Sasaki N, Ohta H, Takiguchi M.Effect of acute volume overload on echocardiographic indices of right ventricular function and dyssynchrony assessed by use of speckle tracking echocardiography in healthy dogs. Am J Vet Res, 80(1):51-60, 2019.
43. Nisa K, Lim SY, Shinohara M, Osuga T, Yokoyama N, Tamura M, Nagata N, Sasaoka K, Dermlim A, Leela-Arporn R, Morita T, Sasaki N, Morishita K, Nakamura K, Ohta H, Takiguchi M.Evaluation of duodenal perfusion by contrast-enhanced ultrasonography in dogs with chronic inflammatory enteropathy and intestinal lymphoma. J Vet Intern Med, 33(2):559-568, 2019.
44. Tamura M, Ohta H, Nisa K, Osuga T, Sasaki N, Morishita K, Takiguchi M.Evaluation of liver and spleen stiffness of healthy dogs by use of two-dimensional shear wave elastography.Am J Vet Res.80(4):378-384,2019.
45. Leela-Arporn R, Ohta H, Tamura M, Nagata N, Sasaoka K, Dermlim A, Nisa K, Osuga T, Morishita K, Sasaki N, Takiguchi M.Plasma-free amino acid profiles in dogs with hepatocellular carcinoma. J Vet Intern Med, 33(4):1653-1659, 2019.
46. Dermlim A, Osuga T, Nakamura K, Morita T, Nisa K, Sasaoka K, Leela-Arporn R, Nagata N, Tamura M, Sasaki N, Ohta H, Takiguchi M.Effect of acute volume loading on left atrial strain values derived from two-dimensional speckle tracking echocardiography in dogs. J Vet Med Sci, 81(7):949-957, 2019.
47. Tamura Y, Ohta H, Kagawa Y, Osuga T, Morishita K, Sasaki N, Takiguchi M.Plasma amino acid profiles in dogs with inflammatory bowel disease.J Vet Intern Med, 33(4):1602-1607, 2019.
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