Epidemiological Research Group Perpetuation mechanisms of pathogens in nature Global surveillance to identify natural host animals and transmission routes of pathogens, as well as an extensive search for unknown potential zoonotic pathogens (i.e., candidate microorganisms that may emerge as new pathogens for humans and animals), will be conducted with the aid of the international collaboration research networks that have been established. Bioinfomatic approach for the prediction and prevention of zoonoses By fusing bioscience and informatics, we will analyze masses of biological data sets to find causative factors for infections, and intend to establish strategies to predict and prevent the occurrence of zoonoses and their spread. Immunological and Pathobiological Research Group Host range and pathogenesis The molecular bases of the mechanisms underlying host range and the pathogenesis of zoonotic infections caused by viruses, bacteria, protozoa, parasites and prions will be investigated. Immune responses against infection The mechanisms underlying the innate and aquired immune responses induced upon infection with microorganisms will be clarified. Diagnostic and Therapeutic Research Group Prophylactic and therapeutic strategies We intend to develop novel vaccination strategies, including immunogens, adjuvants and administration routes. Based on the information obtained from the research activities described above, novel prophylactic and therapeutic strategies will be developed. Diagnostic methods We will develop novel diagnostic methods, such as rapid and simple detection kits with high sensitivity and specificity to pathogens, which will be employed in field research and for bedside use. Cultivation of Human Resource Group All members of this group also belong to other research groups to carry out their own research activities. Collaboration with International Organizations World Health Organization (WHO) World Organization for Animal Health (OIE) Food and Agriculture Organization (FAO) International Collaboration Autonomous Metropolitan University, Mexico, Bogor Agricultural University, Indonesia, Centers for Disease Control and Prevention, USA, Department of Medical Research, Myanmar, Everest International Clinic and Research Center, Nepal, International Livestock Research Institute, Kenya, Lanzhou Veterinary Institute, China, Leonard Wood Memorial, The Philippines, National Institute of Animal Health, Thailand, National Institute of Health, Thailand, National Institute of Health Research and Development, Indonesia, Public Health Agency of Canada, Canada, Seoul National University, Republic of Korea, State Central Veterinary Laboratory, Mongolia, St. Jude Children's Research Hospital, USA, Tribhuban University, Nepal, University of Peradeniya, Sri Lanka, University of the Republic, Uruguay, University of Wisconsin, USA, University of Zambia, Zambia, Yale University, USA..■National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, USA Page Top Global COE Office Graduate School of Veterinary Medicine Hokkaido University N18,W9,Kita-ku, Sapporo, 060-0818 Japan Tel/Fax +81-11-706-5294 gcoe@vetmed.hokudai.ac.jp