2016

Original articles

 

1 ) Nakata, H., Nakayama, S. M. M., Yabe, J., Liazambi, A., Mizukawa, H., Darwish, W. S., Ikenaka, Y. and Ishizuka, M. 2016. Reliability of stable Pb isotopes to identify Pb sources and verifying biological fractionation of Pb isotopes in goats and chickens. Environ. Pollut., 208(Pt B): 395-403. (doi: 10.1016/j.envpol.2015.10.0069)

 

2 ) Mahmoud, A. F. A., Ikenaka,Y., Yohannes, Y. B., Darwish, W. S., Eldaly, E. A., Morshdy, A. E., Nakayama, S. M. M., Mizukawa, H. and Ishizuka, M. 2016. Distribution and health risk assessment of organochlorine pesticides (OCP) residue in edible cattle tissues from northeastern part of Egypt: High accumulation level of OCP in tongue. Chemosphere, 144: 1365-1371. (doi: 10.1016/j.chemosphere.2015.10.016)

 

3 ) Mizukawa, H., Nomiyama, K., Nakatsu, S., Iwata, H., Yoo, J., Kubota, A., Yamamoto, M., Ishizuka, M., Ikenaka, Y., Nakayama, S., Kunisue, T. and Tanabe, S. 2015. Organohalogen compounds in pet dog and cat: Do pets biotransform natural brominated products in food to harmful hydroxlated substances? Environ. Sci. Technol., 50: 444-452. (doi: 10.1021/acs.est.5b04216)

 

4 ) Nishiyama, Y., Nakayama, S. M. M., Watanabe, K. P., Kawai, Y. K., Ohno, M., Ikenaka, Y. and Ishizuka, M. 2016. Strain differences in cytochrome P450 mRNA and protein expression, and enzymatic activity among Sprague Dawley, Wistar, Brown Norway and Dark Agouti rats. J. Vet. Med. Sci., in press. (doi: 10.1021/acs.est.5b04216)

 

5 ) Darwish, W. S., Ikenaka, Y., Nakayama, S. M. M., Mizukawa, H. and Ishizuka, M. 2016. Constitutive Effects of Lead on Aryl Hydrocarbon Receptor Gene Battery and Protection by β-carotene and Ascorbic Acid in Human HepG2 Cells. J. Food. Sci., 81: T275-281. (doi: 10.1111/1750-3841.13162)

 

2015

Original articles

 

1 )  Watanabe K. P., Kawata, M., Ikenaka, Y., Nakayama,  S. M. M., Ishii, C., Darwish, W. S., Saengtienchai, A., Mizukawa, H. and Ishizuka, M. 2015. Cytochrome P450-mediated warfarin metabolic ability is not a critical determinant of warfarin sensitivity in avian species: In vitro assays in several birds and in vivo assays in chicken. Environ. Toxicol. Chem., 34: 2328-2334. (doi: 10.1002/etc.3062)

 

2 ) Kakehi, M., Ikenaka, Y., Nakayama,  S. M. M., Kawai, Y. K., Watanabe, K. P., Mizukawa, H., Nomiyama, K., Tanabe, S. and Ishizuka, M. 2015. Uridine Diphosphate-Glucuronosyltransferase (UGT) Xenobiotic Metabolizing Activity and Genetic Evolution in Pinniped Species. Toxicol. Sci., 147: 360-369. (doi: 10.1093/toxsci/kfv144)

 

3 ) Bortey-Sam, N., Nakayama,  S. M. M., Ikenaka, Y., Akoto, O., Baidoo, E., Mizukawa, H. and Ishizuka, M. 2015. Health risk assessment of heavy metals and metalloid in drinking water from communities near gold mines in Tarkwa, Ghana. Environ. Monit. Assess., 187: 397. (doi: 10.1007/s10661-015-4630-3)

 

4 ) Darwish, W. S., Nakayama, S. M. M., Itotani, Y., Ohno, M., Ikenaka, Y. and Ishizuka, M. 2015. Metabolic Activation of Heterocyclic Amines and Expression of Xenobiotic-Metabolizing Enzymes in the Gastrointestinal Tract of Rats. J. Food. Sci., 80: T1627-1632. (doi: 10.1111/1750-3841.12931)

 

5 ) Darwish, W. S., Hussein, M. A., El-Desoky, K. I., Ikenaka, Y., Nakayama, S. M. M., Mizukawa, H. and Ishizuka, M. 2015. Incidence and public health risk assessment of toxic metal residues (cadmium and lead) in Egyptian cattle and sheep meats. International Food Research Journal, 22: 1719-1726.

 

6 ) Mizukawa, H., Nomiyama, K., Kunisue, T., Watanabe, M. X., Subramanian, A., Iwata, H., Ishizuka, M. and Tanabe, S. 2015. Organohalogens and their hydroxylated metabolites in the blood of pigs from an open waste dumping site in south India: association with hepatic cytochrome P450. Environ. Res., 138: 255-263. (doi: 10.1016/j.envres.2015.02.012)

 

7 ) Watanuki, Y., Yamamoto, T., Yamashita, A., Ishii, C., Ikenaka, Y., Nakayama, S. M. M., Ishizuka, M., Suzuki, Y., Niizuma, Y., Meathrel, C. E. and Phillips, R. A. 2015. Mercury concentrations in primary feathers reflect pollutant exposure in discrete non-breeding grounds used by Short-tailed Shearwaters. Journal of Ornithology, 156: 847-850. (doi: 10.1007/s10336-015-1205-6)

 

8 ) Bortey-Sam, N., Ikenaka, Y., Akoto, O., Nakayama, M. M. S., Yared, Y. B., Baidoo, E., Mizukawa, H. and Ishizuka, M. 2015. Levels, potential sources and human health risk of polycyclic aromatic hydrocarbons (PAHs) in particulate matter (PM10) in Kumasi-Ghana. Environ. Sci. Pollut. Res. Int., 22: 9658-9667. (doi: 10.1007/s11356-014-4022-1)

 

9 ) Yabe, J., Nakayama, S. M. M., Ikenaka, Y., Yohannes, Y. B., Bortey-Sam, N., Oroszlany, B., Muzandu, K., Choongo, K., Kabalo, A. N., Ntapisha, J., Mweene, A., Umemura, T. and Ishizuka, M. 2015. Lead poisoning in children from townships in the vicinity of a lead-zinc mine in Kabwe, Zambia. Chemosphere, 119: 941-947. (doi: 10.1016/j.chemosphere.2014.09.028)

 

10) Bortey-Sam, N., Nakayama, S. M. M., Ikenaka, Y., Akoto, O., Yohannes, Y. B., Baidoo, E., Mizukawa, H. and Ishizuka, M. 2015. Human health risks from metals and metalloid via consumption of food animals near gold mines in Tarkwa, Ghana: estimation of the daily intakes and target hazard quotients (THQs). Ecotoxicol. Environ. Saf. 111: 160-167. (doi: 10.1016/j.ecoenv.2014.09.008)

 

11) Watanabe, K. P., Kawai, Y. K., Nakayama, S. M. M., Ikenaka, Y., Mizukawa, H., Takaesu, N., Ito, M., Ikushiro, S., Sakaki, T. and Ishizuka, M. 2015. Partial cloning of CYP2C23a genes and hepatic protein expression in eight representative avian species. J. Vet. Pharmacol. Ther., 38: 190-195. (doi: 10.1111/jvp.12159)

 

12) Saengtienchai, A., Ikenaka, Y., Nakayama, S. M. M., Mizukawa, H., Kakehi, M., Bortey-Sam, N., Darwish, W., Tsubota, T., Terasaki, M., Poapolathep, A. and Ishizuka, M. 2015. Identification of interspecific differences in phase II reactions: determination of metabolites in the urine of 16 mammalian species exposed to environmental pyrene. Environ. Toxicol. Chem., 33: 2062-2069. (doi: 10.1002/etc.2656)

 

13) Nakata, H., Nakayama, S. M. M., Ikenaka, Y., Mizukawa, H., Ishii, C., Yohannes,  Y. B., Konnai, S., Darwish, W. S. and Ishizuka, M. 2015. Metal extent in blood of livestock from Dandora dumping site, Kenya: source identification of Pb exposure by stable isotope analysis. Environ. Pollut., 205: 8-15. (doi: 10.1016/j.envpol.2015.05.003)

 

14) Saengtienchai, A., Ikenaka, Y., Darwish, W. S., Nakayama, S. M. M., Mizukawa, H. and Ishizuka, M. 2015. Characterization and tissue distribution of conjugated metabolites of pyrene in the rat. J. Vet. Med. Sci., 77: 1261-1267. (doi: 10.1292/jvms.14-0632)

 

15) Ikenaka, Y., Nakayama, S. M. M., Oguri, M., Saengtienchai, A., Mizukawa, H., Kobayashi, J., Darwish, W. S. and Ishizuka, M. 2015. Are red gourami (Colisa labiosa) low xenobiotic metabolizers? Elucidation of in vivo pharmacokinetics of pyrene as a model substrate. Environ. Toxicol. Pharmacol., 39: 1148-1153. (doi: 10.1016/j.etap.2015.04.004)

 

16) Bortey-Sam, N., Nakayama, S. M. M., Akoto, O., Ikenaka, Y., Fobil, N. J., Baidoo, E., Mizukawa, H. and Ishizuka, M. 2015. Accumulation of heavy metals and metalloid from agricultural soils to foodstuffs around Tarkwa area in Ghana, and associated human health risks. Int. J. Environ. Res. Public Health., 12: 8811-8827. (doi: 10.3390/ijerph120808811)

 

17) Gerber, R., Smit, N., van Vuren, J., Nakayama, S. M. M., Yohannes, Y. B., Ikenaka, Y., Ishizuka, M. and Wepener, V. 2015. Application of a Sediment Quality Index for the assessment and monitoring of metals and organochlorines in a premier conservation area. Environmental Science and Pollution Research, 22: 19971-19989. (doi: 10.1007/s11356-015-5206-z)

 

18) Bortey-Sam N., Nakayama S. M. M., Akoto, O., Ikenaka, Y., Fobil, N. J., Baidoo, E., Mizukawa, H. and Ishizuka, M. 2015. Ecological Risk of Heavy Metals and a Metalloid in Agricultural Soils in Tarkwa, Ghana. Int. J. Environ. Res. Public Health, 12: 11448-11465. (doi: 10.3390/ijerph120911448)

 

19) Teraoka, H., Okamoto, E., Kudo, M., Nakayama, S. M. M., Ikenaka, Y., Ishizuka, M., Endo, T., Kitazawa, T. and Hiraga, T. 2015. Accumulation properties of inorganic mercury and organic mercury in the red-crowned crane Grus japonensis in east Hokkaido, Japan. Ecotoxicol. Environ. Saf., 122: 557-564. (doi: 10.1016/j.ecoenv.2015.09.025)

 

20) Darwish, W. S., Ikenaka, Y., Morshdy, A. E., Eldesoky, K. I., Nakayama, S. M. M., Mizukawa, H. and Ishizuka, M. 2015. β-carotene and retinol contents in the meat of herbivorous ungulates with a special reference to their public health importance. J. Vet. Med. Sci., in press. (doi: 10.1292/jvms.15-0287)

 

21) Marfo, J. T., Fujioka, K., Ikenaka, Y., Nakayama, S. M. M., Mizukawa, H., Aoyama, Y., Ishizuka, M. and Taira, K. 2015. Relationship between urinary N-desmethyl-acetamiprid and typical symptoms including neurological findings: A prevalence case-control study. PLoS One, 10: e0142172. (doi: 10.1371/journal.pone.0142172)

 

22) Yoo, J., Hirano, M., Mizukawa, H., Nomiyama, K., Agusa, T., Kim, E. Y., Tanabe, S. and Iwata, H. 2015. In vitro and in silico analyses for predicting hepatic cytochrome P450-dependent metabolic potencies of polychlorinated biphenyls in the Baikal seal. Environ. Sci. Technol., 49: 14588-14596. (doi: 10.1021/acs.est.5b03890)

 

2014

Original articles

 

1 ) Ishii, C., Ikenaka, Y., Nakayama S. M. M., Suzuki, Y., Watanuki, Y., Watanabe, Y., Yohannes, Y. B., Mizukawa, H. and Ishizuka, M. 2014. Contamination status and accumulation characteristics of metals and a metalloid in birds on Teuri Island, Hokkaido, Japan. Jpn. J. Vet. Res., 62: 143-149. (doi: 10.14943/jjvr.62.3.143)

 

2 ) Fujisawa, N., Nakayama, S. M. M., Ikenaka, Y. and Ishizuka, M. 2014. TCDD-induced chick cardiotoxicity is abolished by a selective cyclooxygenase-2 (COX-2) inhibitor NS398. Arch. Toxicol., 88: 1739-1748. (doi: 10.1007/s00204-014-1225-7)

 

3 ) Bortey-Sam, N., Ikenaka, Y., Nakayama, S. M. M., Akoto, O., Yohannes, Y. B., Baidoo, E., Mizukawa, H. and Ishizuka, M. 2014. Occurrence, distribution, sources and toxic potential of polycyclic aromatic hydrocarbons (PAHs) in surface soils from the Kumasi Metropolis, Ghana. Sci. Total. Environ., 496: 471-478. (doi: 10.1016/j.scitotenv.2014.07.071)

 

4 ) Mizukawa, H., Ikenaka, Y., Nakayama, S. M. M., Sakamoto, K. Q., Fujita, S. and Ishizuka, M. 2014. Contamination status and possibility of toxic effects of co-planar polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and dichlorodiphenyltrichloroethane in large Japanese field mouse (Apodemus speciosus) collected from Hokkaido and Aomori. Jpn. J. Vet. Res., 62: 107-115. (doi: 10.14943/jjvr.62.3.107)

 

5 ) Yohannes, Y. B., Ikenaka, Y., Nakamyama, S. M. M. and Ishizuka, M. 2014. Organochlorine pesticides in bird species and their prey (fish) from the Ethiopian Rift Valley region, Ethiopia. Environ. Pollut., 192: 121-128. (doi: 10.1016/j.envpol.2014.05.007)

 

6 ) Yohannes, Y. B., Ikenaka, Y., Saengtienchai, A., Watanabe, K. P., Nakamyama, S. M. M. and Ishizuka, M. 2014. Concentrations and human health risk assessment of organochlorine pesticides in edible fish species from a Rift Valley Lake – Lake Ziway, Ethiopia. Ecotox. Environ. Saf., 106: 95-101. (doi: 10.1016/j.ecoenv.2014.04.014)

 

7 ) Yasui, H., Takeuchi, R., Nagane, M., Meike, S., Nakamura, Y., Yamamori, T., Ikenaka, Y., Kon, Y., Murotani, H., Oishi, M., Nagasaki, Y. and Inanami, O. 2014. Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles. Cancer. Lett., 347: 151-158. (doi: 10.1016/j.canlet.2014.02.005)

 

8 ) Akoto, O., Bortey-Sam, N., Nakayama, S. M. M., Ikenaka, Y., Baidoo, E., Yohannes, Y. B., Mizukawa, H. and Ishizuka, M. 2014. Distribution of heavy metals in organs of sheep and goat reared in Obuasi: A gold mining town in Ghana. International Journal of Environmental Science and Toxicology Research, 2: 81-89.

 

9 ) M’kandawire, E., Syakalima, M., Muzandu, K., Pandey, G., Simuunza, M., Nakayama, S. M. M., Kawai, Y. K., Ikenaka, Y. and Ishizuka, M. 2014. Molecular characterization and mRNA expression of cytochrome P450 1A1 and cytochrome P450 3A in liver of Kafue Lechwe (Kobus leche kafuensis) as potential biomarkers of pollution of the Kafue River basin, Zambia. Engineering., 6: 51-58. (doi: 10.4236/eng.2014.62008)

 

10) Darwish, W. S., Ikenaka, Y., Nakayama, S. M. M. and Ishizuka, M. 2014. The effect of copper on the mRNA expression profile of xenobiotic-metabolizing enzymes in cultured rat H4-II-E cells. Biol. Trace Elem. Res., 158: 243-248. (doi: 10.1007/s12011-014-9915-9)

 

11) Saengtienchai, T., Poapolathep, S., Isariyodom, S., Ikenaka, Y., Ishizuka, M. and Poapolathep, A. 2014. Toxicokinetics and tissue depletion of Fusarenon-X and its metabolite nivalenol in piglets. Food Chem Toxicol., 66: 307-312. (doi: 10.1016/j.fct.2014.01.053)

 

Review article

 

1 ) Darwish, W. S., Ikenaka, Y., Nakayama, S. M. M. and Ishizuka, M. 2014. An overview on mycotoxin contamination of foods in Africa. J. Vet. Med. Sci., 76: 789-797. (doi: 10.1292/jvms.13-0563)

 

2013

Original articles

 

1 ) Yabe, J., Nakayama, S. M. M., Ikenaka, Y., Muzandu, K., Choongo, K., Mainda, G., Kabeta, N., Ishizuka, M. and Umemura, T. 2013. Metal distribution in tissues of free-range chickens near a lead-zinc mine in Kabwe, ZambiaEnviron. Toxicol. Chem., 32: 189-192.

 

2 ) Nakayama, S. M. M., Ikenaka, Y., Muzandu, K., Choongo, K., Yabe, J., Muroya, M., Ijiri, S., Minagawa, M., Umemura, T. and Ishizuka, M. 2013. GIS-based source estimation of Cu pollution in Lake Itezhi-tezhi and metal accumulation profiles in Oreochromis spp. from both field and laboratory studies. Arch. Environ. Contam. Toxicol., 64: 119-129.

3 ) Shimamoto, Y., Kitamura, H., Niimi, K., Yoshikawa, Y., Hoshi, F., Ishizuka, M., and Takahashi, E. 2013. Selection of suitable reference genes for mRNA quantification studies using common marmoset tissuesMol. Biol. Rep., 40: 6747-6755.

4 ) Ikenaka, Y., Oguri, M., Saengtienchai, A., Nakayama, S.M.M., Ijiri, S. and Ishizuka, M. 2013. Characterization of Phase-II conjugation reaction of polycyclic aromatic hydrocarbons in fish species: unique pyrene metabolism and species specificity observed in fish speciesEnviron. Toxicol. Pharmacol., 36: 567-578.

5 ) Kawai, Y. K., Watanabe, K. P., Ishii, A., Onuma, A., Sawa, H., Ikenaka, Y. and Ishizuka, M. 2013. De novo sequence analysis of cytochrome P450 1–3 genes expressed in ostrich liver with highest expression of CYP2G19Comp. Biochem. Physiol. D, 8: 201-208.

6 ) Yohannes, Y. B., Ikenaka, Y., Saengtienchai, A., Watanabe, K. P., Nakamyama, S.M.M. and Ishizuka, M. 2013. Occurrence, distribution and ecological risk assessment of DDTs and heavy metals in surface sediments from Lake Awassa – Ethiopian Rift Valley LakeEnviron. Sci. Pollut. Res., 20: 8663–8671.

7 ) Fujisawa, N., Darwish, W. S., Ikenaka, Y., Kim, E., Lee, J., Iwata. H., Nakayama, S.M.M. and Ishizuka, M. 2013. Molecular evaluation of a new highly sensitive aryl hydrocarbon receptor in ostrichesPoult. Sci., 92: 1921-1929.

8 ) Yared, B. Y., Ikenaka, Y., Nakayama, S. M. M., Saengtienchai, A., Watanabe, K. and Ishizuka, M. 2013. Organochlorine pesticides and heavy metals in fish from Lake Awassa; Ethiopia: Insights from stable isotope analysisChemosphere, 91: 857-863.

9 ) Nakayama, S. M. M., Ikenaka, Y., Hamada, K., Muzandu, K., Choongo, K., Yabe, J., Umemura, T. and Ishizuka, M. 2013. Accumulation and biological effects of metals in wild rats in mining areas of ZambiaEnviron. Monit. Assess., 185: 4907-4918.

10) Tanaka, K. D., Kawai, Y. K., Ikenaka, Y., Harunari, T., Tanikawa, T., Fujita, S. and Ishizuka, M. 2013. A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant ratsJ. Vet. Med. Sci., 75: 135-139.

11) Ikenaka, Y., Sakamoto, M., Nagata, T., Takahashi, H., Miyabara, Y., Hanazato, T., Ishizuka, M., Isobe, T., Kim, J. W. and Chang, K. H. 2013. Effects of polycyclic aromatic hydrocarbons (PAHs) on an aquatic ecosystem: acute toxicity and community-level toxic impact tests of benzo[a]pyrene using lake zooplankton communityJ. Toxicol. Sci. 38: 131-136.

 

12) Ibrahim, Z. S., Ahmed, M. M., Shukry, M. M., Mahmoud, S. and Ishizuka, M. 2013. Constitutive androstane receptor dependent and independent modulation of CYP3A2, CYP1A2 by phenobarbital and fibrate in rats’ liver. American Journal of Biochemistry and Biotechnology, 9: 272-281.

 

13) Kitamura, H., Kimura, S., Shimamoto, Y., Okabe, J., Ito, M., Miyamoto, T., Naoe, Y., Kikuguchi, C., Meek, B., Toda, C., Okamoto, S., Kanehira, K., Hase, K., Watarai, H., Ishizuka, M., El-Osta, A., Ohara, O. and Miyoshi, I. 2013. Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation. FASEB J., 27: 4940-4953.

 

14) Watanabe, K. P., Kawai, Y. K., Ikenaka, Y., Kawata, M., Ikushiro, S., Sakaki, T. and Ishizuka, M. 2013. Avian cytochrome P450 (CYP) 1-3 family genes: isoforms, evolutionary relationships, and mRNA expression in chicken liver. PLoS One, 8: e75689.

 

15) Fujisawa, N., Kawai, Y. K., Nakayama, S. M. M., Ikenaka, Y., Yamamoto, H. and Ishizuka, M. 2013. Dioxin sensitivity-related two critical amino acids of  arylhydrocarbon receptor may not correlate with the taxonomy or phylogeny in avian species. J. Vet. Med. Sci., 75: 1577-1583.

 

16) Sasaki, N., Matumoto, T., Ikenaka, Y., Nakayama, S. M. M., Ishizuka, M., Kazusaka, A. and Fujita, S. 2013. Repeated treatment with furazolidone induces multiple cytochrome P450-related activities in chicken liver, but not in rat liver. J. Vet. Med. Sci,. 75: 1497-1502.

 

2012

Original articles

 

1 ) Ohno, M., Ikenaka, Y. and Ishizuka, M. 2012. Sudan III dye strongly induces CYP1A1 mRNA expression in HepG2 cellsJ. Biochem. Mol. Toxicol., 26: 16-22. (doi: 10.1002/jbt.20408) 

2 ) Fujisawa, N., Ikenaka, Y., Kim, E.Y., Lee, J.S., Iwata, H. and Ishizuka, M. 2012. Molecular Evidence Predicts Aryl Hydrocarbon Receptor Ligand Insensitivity in the Peregrine Falcon (Falco peregrines). Eur. J. Wildlife. Res. 58: 167-175. 

3 ) Ohno, M., Ikenaka, Y. and Ishizuka, M. 2012. All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells. Biochem Biophys Res Commun. 417: 484-489. 

4 ) Shimamoto, Y., Sasaki, M., Ikadai, H., Ishizuka, M., Yokoyama, N., Igarashi, I., Hoshi, F. and Kitamura, H. 2012. Down-Regulation of Hepatic Cytochrome P450 3A in Mice Infected with Babesia microtiJ. Vet. Med. Sci., 74: 241-5.

5 ) Nakayama, S.M., Ikenaka, Y., Muzandu, K., Choongo, K., M'kandawire, E., Yasuda, J. and Ishizuka, M. 2012. Metal and metalloid levels and bio-accumulation characteristics in soil, sediment, land plants and hippopotami (Hippopotamus amphibius L) from the South Luangwa National Park, ZambiaEcotoxicol. Environ. Safe. 80: 333-8.

6 ) Suzuki, S., Konnai, S., Okagawa, T., Githaka, N.W., Kariuki, E., Gakuya, F., Kanduma, E., Shirai, T., Ikebuchi, R., Ikenaka, Y., Ishizuka, M., Murata, S. and Ohashi, K. 2012. Molecular cloning and characterization of Th1 and Th2 cytokines of African buffalo (Syncerus caffer)Int. J. Immunogenet. 39: 170-82.(doi: 10.1111/j.1744-313X.2011.01062.x)
 
7 ) Uno, T., Ishizuka, M. and Itakura, T. 2012. Cytochrome P450 (CYP) in fishEnviron. Toxicol. Pharmacol. 34: 1-13.

8 ) Kawamoto, K., Otsuguro, K., Ishizuka, M. and Ito, S. 2012. Inhibitory effects of dopamine on spinal synaptic transmission via D1-like receptors in neonatal ratsBr. J. Pharmacol. 166: 788-800. (doi: 10.1111/j.1476-5381.2011.01815.x)

9 ) Okagawa, T., Konnai, S., Mekata, H., Githaka, N., Suzuki, S., Kariuki, E., Gakuya, F., Kanduma, E., Shirai, T., Ikebuchi, R., Ikenaka, Y., Ishizuka, M., Murata, S. and Ohashi, K. 2012. Transcriptional profiling of inflammatory cytokine genes in African buffaloes (Syncerus caffer) infected with Theileria parvaVet. Immunol. Immunopathol. 148: 373-379.

10) M'kandawire, E., Syakalima, M., Muzandu, K., Pandey, G., Simuunza, M., Nakayama, S.M., Kawai, Y.K., Ikenaka, Y. and Ishizuka, M. 2012. The nucleotide sequence of metallothioneins (MT) in liver of the Kafue lechwe (Kobus leche kafuensis) and their potential as biomarkers of heavy metal pollution of the Kafue River. Gene. 506: 310-316.

11) Tanaka, K. D., Kawai, Y., Ikenaka, Y., Harunari, T., Tanikawa, T., Ando, S., Min, H. W., Okajima, F., Fujita, S. and Ishizuka, M. 2012. The genetic mechanisms of warfarin resistance in Rattus rattus found in the wild in JapanPestic. Biochem. Physiol. 103: 144-151.

12) Mureithi, D., Darwish, W. S., Ikenaka, Y., Kanja, L. and Ishizuka, M. 2012. Cytochrome P450 3A mRNA expression along goat and rat astrointestinal tractsJpn. J. Vet. Res., 60: 205-210.

13) Yabe, J., Nakayama, S.M.M., Ikenaka, Y., Muzandu, K., Ishizuka, M. and Umemura, T. 2012. Accumulation of metals in the liver and kidneys of cattle from agricultural areas in Lusaka, Zambia. J. Vet. Med. Sci., 74: 1345-1347.

14) Ikenaka, Y., Nakayama, S. M. M., Muroya, T., Yabe, J., Konnai, S., Darwish, W. S., Muzandu, K., Choongo, K., Mainda, G., Teraoka, H., Umemura, T. and Ishizuka, M. 2012. Effects of environmental lead contamination on cattle in a lead/zinc mining area: changes in cattle immune systems on exposure to lead in vivo and in vitroEnviron. Toxicol. Chem., 31: 2300-2305.

 

2011

Original articles

 

1 ) Nakayama, S. M. M., Ikenaka, Y., Hamada, K., Muzandu, K., Choongo, K., Teraoka, H., Mizuno, N. and Ishizuka, M. 2011. Metal and metalloid contamination in roadside soil and wild rats around a Pb-Zn mine in Kabwe, ZambiaEnviron. Poll., 159: 175-181.(doi:10.1016/j.envpol.2010.09.007) 

2 ) Ohno, M., Darwish, W.S., Ikenaka, Y., Miki, W. and Ishizuka, M. 2011. Astaxanthin can alter CYP1A-dependent activities via two different mechanisms : Induction of protein expression and inhibition of NADPH P450 reductase dependent electron transferFood Chem. Toxicol., 49: 1285-1291. (doi: 10.1016/j.fct.2011.03.009)

3 ) Sasaki, N., Matsumoto, T., Ikenaka, Y., Kazusaka, A., Ishizuka, M. and Fujita, S. 2011. Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickensPestic. Biochem. Physiol., 100: 135-139. (doi:10.1016/j.pestbp.2011.02.013)

4 ) Ueda, H., Ikenaka, Y., Nakayama, S.M., Tanaka-Ueno, T. and Ishizuka, M. 2011. Phase-II conjugation ability for PAH metabolism in amphibians: Characteristics and inter-species differencesAquat. Toxicol. 105: 337-343. (doi:10.1016/j.aquatox.2011.07.004)

5 ) Ohno, M., Darwish, W.S., Ikenaka, Y., Miki, W., Fujita, S. and Ishizuka, M. 2011. Astaxanthin rich crude extract of Haematococcus pluvialis induces cytochrome P450 1A1 mRNA by activating aryl hydrocarbon receptor in rat hepatoma H4IIE cellsFood Chem. 130: 356-361. (doi:10.1016/j.foodchem.2011.07.050)

6 ) Yabe, J., Nakayama, S.M., Ikenaka, Y., Muzandu, K., Ishizuka, M. and Umemura, T. 2011. Uptake of lead, cadmium, and other metals in the liver and kidneys of cattle near a lead-zinc mine in Kabwe, Zambia. Environ. Toxicol. Chem. 30: 1892-1897. (doi: 10.1002/etc.580) 

7 ) Saengtienchai, A., Ikenaka, Y., Watanabe, K., Ishida, T. and Ishizuka, M. 2011. Comparative metabolism of warfarin in rats and chickens. Poult Sci. 90: 2775-2781. 

 

2010

Original articles

 

1 ) Watanabe, K.P., Saengtienchai, A., Tanaka, K.D., Ikenaka, Y. and Ishizuka, M. 2010. Comparison of warfarin sensitivity between rat and bird speciesComp. Biochem. Physiol. C Toxicol. Pharmacol., 152: 114-119. (doi:10.1016/j.cbpc.2010.03.006)

2 ) Darwish, W.S., Morshdy, A.E., Ikenaka, Y., Ibrahim, Z.S., Fujita, S. and Ishizuka, M. 2010. Expression and Sequence of CYP1A in CamelJ. Vet. Med. Sci., 72: 221-224. (doi:10.1292/jvms.09-0319)

3 ) Kim, H.S., Sakai, N., Saito, K., Fujita, S. and Ishizuka, M. 2010. Diazepam metabolism in kidney of male and female rats of varying strainJ. Vet. Med. Sci., 72: 7-11. (doi:10.1292/jvms.09-0127)

4 ) Sakamoto, Q.K., Sato, K., Kato, A., Fukui, D., Bando, G., Naito, Y., Habara, Y., Ishizuka, M. and Fujita, S. 2010. Metabolic alkalosis due to feeding chicks in breeding Adelie penguins Pygoscelis adeliae under natural conditionsPhysiol. Biochem. Zool., 83: 232-238. (doi:10.1086/597517)
 
5 ) Darwish, W.S., Ikenaka, Y., Eldaly, E.A., Ohno, M., Sakamoto, K.Q., Fujita, S. and Ishizuka, M. 2010. Cytochrome P450 1A-dependent activities in deer, cattle and horses.J Vet Med Sci. 72: 561-566. (doi:10.1292/jvms.09-0318)

6 ) Takiguchi, M., Darwish, W.S., Ikenaka, Y., Ohno, M. and Ishizuka, M. 2010. Metabolic Activation of Heterocyclic Amines and Expression of CYP1A1 in the Tongue.Toxicol. Sci., 116: 79-91. (doi:10.1093/toxsci/kfq087)

7 ) Kawai, Y.K., Ikenaka, Y., Fujita, S., Ishizuka, M. 2010. The CYP1D subfamily of genes in mammals and other vertebratesMamm. Genome, 21: 320-329. (doi:10.1007/s00335-010-9263-9)

8 ) Darwish, W., Ikenaka, Y., Eldaly, E., Ishizuka, M. 2010. Mutagenic activation and detoxification of benzo[a]pyrene in vitro by hepatic cytochrome P450 1A1 and phase II enzymes in three meat-producing animalsFood Chem. Toxicol., 48: 2526-2531. (doi:10.1016/j.fct.2010.06.026)

9 ) Chang, H.S., Ko, M., Ishizuka, M., Fujita, S., Yabuki, A., Hossain, M.A., Yamato, O. 2010. Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cellsNutr. Res., 30: 435-440. (doi:10.1016/j.nutres.2010.06.007)

10) Nakayama, S.M., Ikenaka, Y., Muzandu, K., Choongo, K., Oroszlany, B., Teraoka, H., Mizuno, N. and Ishizuka, M. 2010. Heavy Metal Accumulation in Lake Sediments, Fish (Oreochromis niloticus and Serranochromis thumbergi), and Crayfish (Cherax quadricarinatus) in Lake Itezhi-tezhi and Lake Kariba, Zambia. Arch. Environ. Contam. Toxicol., 59: 291-300. (doi:10.1007/s00244-010-9483-8) 

11) Darwish W. S., Ikenaka Y, El-Ghareeb W. R. and Ishizuka M. 2010. High expression of the mRNA of cytochrome P450 and phase II enzymes in the lung and kidney tissues of cattleAnimal, 4: 2023-2029. (doi: 10.1017/S1751731110001394) 

12) Darwish, W. S., Ikenaka, Y., Ohno, M., Eldaly, E. A. and Ishizuka, M. 2010. Carotenoids as regulators for inter-species difference in cytochrome P450 1A expression and activity in ungulates and ratsFood Chem. Toxicol. 48: 3201-3208. (doi:10.1016/j.fct.2010.08.022) 

13) Sata, F., Kurahashi, N., Ban, S., Moriya, K., Tanaka, K.D., Ishizuka, M., Nakao, H., Yahata, Y., Imai, H., Kakizaki, H., Nonomura, K. and Kishi, R. 2010. Genetic polymorphisms of 17β-hydroxysteroid dehydrogenase 3 and the risk of hypospadias. J. Sex. Med., 7: 2729-2738. (doi: 10.1111/j.1743-6109.2009.01641.x)

14) Darwish, W.S., Kawai, Y., Ikenaka, Y., Yamamoto, H., Muroya, T. and Ishizuka, M. 2010. Identification and phylogenetic analysis of novel cytochrome P450 1A genes from ungulate speciesJ. Vet. Med. Sci. 72: 1237-1241. (doi:10.1292/jvms.10-0019)

15) Ikenaka, Y., Nakayama, S. M. M., Muzandu, K., Choongo, K., Teraoka, H., Mizuno, N. and Ishizuka, M. 2010. Heavy metal contamination of soil and sediment in Zambia. African Journal of Environmental Science & Technology 4: 729-739. 

16) Yabe, J., Ishizuka, M. and Umemura, T. 2010. Current levels of heavy metal pollution in AfricaJ. Vet. Med. Sci., 72: 1257-1263. (doi:10.1292/jvms.10-0058)

 

2009

Original articles

 

1 ) Sakai, N. and Ishizuka, M. 2009. Impact of rat P450 genetic polymorphism on diazepam metabolismExpert Opin. Drug Metab. Toxicol., 5: 1421-1433.

2 ) El Bohi, K. M., Hashimoto, Y., Muzandu, K., Ikenaka, Y., Ibrahim, Z. S., Kazusaka, A., Fujita, S. and Ishizuka, M. 2009. Protective effect of Pleurotus cornucopiae mushroom on carbon tetrachloride-induced hepatotoxicityJpn. J. Vet. Res., 57: 109-118.

3 ) Nakayama, S. M. M., Tanaka-Ueno, T., Sakamoto, Q. K., Fujita, S. and Ishizuka. M. 2009. Molecular cloning of novel cytochrome P450 1A genes from nine Japanese amphibian speciesJ. Vet. Med. Sci., 71: 1407-1411.

4 ) Sakai, N., Sakamoto, K. Q., Fujita, S. and Ishizuka, M. 2009. The importance of heterogeneous nuclear ribonucleoprotein K on Cytochrome P450 2D2 gene regulation: its binding is reduced in Dark Agouti rats. Drug Metab. Dispos., 37: 1703-1710.

5 ) Sakamoto, K. Q., Sato, K., Ishizuka, M., Watanuki, Y., Takahashi, A., Daunt, F. and Wanless, S. 2009. Can ethograms be automatically generated using body acceleration data from free-ranging birds? PLoS ONE., e5379.

6 ) Ohno, M., Sakamoto, K. Q., Ishizuka, M. and Fujita, S. 2009. Crude cacao Theobroma cacao extract reduces mutagenicity induced by benzo[a]pyrene through inhibition of CYP1A activity in vitroPhytother, Res., 23: 1134-1139.

7 ) Sakai, N., Saito, K., Sakamoto, Q. K., Ishizuka, M. and Fujita, S. 2009. Genetic basis of inter- and intrastrain differences in diazepam p-hydroxylation in ratsDrug Metab. Dispos. 37: 268-271.

8 ) Nakano, K., Ishizuka, M., Sakamoto, Q. K. and Fujita, S. 2009. Absolute requirement for iron in the development of chemically induced uroporphyria in mice treated with 3-methylcholanthrene and 5-aminolevulinateBiometals, 22: 345-351.

9 ) Sakamoto, Q. K., Sato, K., Naito, Y., Habara, Y., Ishizuka, M. and Fujita, S. 2009. Morphological features and blood parameters of Weddell seal (Leptonychotes weddellii) mothers and pups during the breeding seasonJ. Vet. Med. Sci., 71: 341-344.

10) Tanaka, K., Harunari, T., Tanikawa, T., Ikenaka, Y. and Ishizuka, M. 2009. Warfarin-resistant of rats in JapanJpn. J. Environ. Toxicol, 12: 61-70. (in Japanese).

 

2008

Original articles

 

1 ) Ishizuka, M., Fujioka, K. and Shibamoto, T. 2008. Analysis of acrylamide in a complex matrix of polyacrylamide solutions treated by heat and ultraviolet lightJ. Agric. Food Chem, 56: 6093-6096.

2 ) Refat, N. A., Ibrahim, Z. S., Moustafa, G. G., Sakamoto, K. Q., Ishizuka, M. and Fujita, S. 2008. The induction of cytochrome P450 1A1 by sudan dyes. J. Biochem. Mol. Toxicol, 22: 77-84.

3 ) Ibrahim, S. Z., Ishizuka, M., Soliman, M., ElBohi, K., Sobhy, W., Muzandu, K., Elkattawy, M. A., Sakamoto, Q. K. and Fujita, S. 2008. Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in ratsJpn. J. Vet. Res, 56: 119-128.

4 ) Moustafa, G. G., Ibrahim, Z. S., Ahmed, M. M., Ghoneim, M. H., Sakamoto, K. Q., Ishizuka, M. and Fujita, S. 2008. Downregulation of male-specific cytochrome P450 by profenofosJpn. J. Vet. Res, 56: 109-118.

5 ) Ishizuka, M., Tanikawa, T., Tanaka, K. D., Heewon, M., Okajima, F., Sakamoto, K. Q. and Fujita, S. 2008. Pesticide resistance in wild mammals--mechanisms of anticoagulant resistance in wild rodents. J. Toxicol. Sci, 33: 283-291.

6 ) Sasaki, N., Sakai, N., Ikenaka, Y., Kamiya, T., Heewon, M., Sakamoto, K. Q., Ishizuka, M. and Fujita, S. 2008. Antibiotic furazolidone induces CYP1A but not CYP2E1 subfamily in rat liverJ. Vet. Med. Sci, 70: 223-226.

7 ) Sasaki, S., Sata, F., Katoh, S., Saijo, Y., Nakajima, S., Washino, N., Konishi, K., Ban, S., Ishizuka, M. and Kishi, R. 2008. Adverse birth outcomes associated with maternal smoking and polymorphisms in the N-Nitrosamine-metabolizing enzyme genes NQO1 and CYP2E1Am. J. Epidemiol, 167: 719-726.

 

2007

Original articles

 

1 ) Moustafa, G. G., Ibrahim, Z. S., Hashimoto, Y., Alkelch, A. M., Sakamoto, K. Q., Ishizuka, M. and Fujita, S. 2007. Testicular toxicity of profenofos in matured male rats. Arch. Toxicol., 81: 875-81.

2 ) Ban, S., Kondo, T., Ishizuka, M., Sasaki, S., Konishi, K., Washino, N., Fujita, S. and Kishi, R. 2007. Using Microarray Analysis to Evaluate Genetic Polymorphisms Involved in the Metabolism of Environmental Chemicals. Fukuoka Acta Medica, 89: 208-214.

3 ) Ishizuka, M., Nagai, S., Sakamoto, K. Q. and Fujita, S. 2007. Plasma pharmacokinetics and CYP3A12-dependent metabolism of c-kit inhibitor imatinib in dogs. Xenobiotica,. 37: 503-13.

4 ) Ishizuka, M., Okajima, F., Tanikawa, T., Min, H., Tanaka, K. D., Sakamoto, K. Q. and Fujita, S. 2007. Elevated warfarin metabolism in warfarin-resistant roof rats (Rattus rattus) in Tokyo. Drug Metab. Dispos., 35: 62-6.

5 ) Kim, H. S., Ishizuka, M., Kazusaka, A. and Fujita, S. 2007. Di-(2-ethylhexyl)phthalate suppresses tamoxifen-induced apoptosis in GH3 pituitary cells. Arch. Toxicol., 81: 27-33.

 

2006

Original articles

 

1 ) Jinno, A., Maruyama, Y., Ishizuka, M., Kazusaka, A., Nakamura, A. and Fujita, S. 2006. Induction of cytochrome P450-1A by the equine estrogen equilenin, a new endogenous aryl hydrocarbon receptor ligand. J. Steroid. Biochem. Mol Biol., 98: 48-55.

2 ) Ishizuka, M., Lee, J.J., Masuda, M., Akahori, F., Kazusaka, A. and Fujita, S. 2006. CYP2D-related metabolism in animals of the Canoidea superfamily-species differences. Vet. Res. Commun., 30: 505-512.

3 ) Sasaki, S., Kondo, T., Sata, F., Saijo, Y., Katoh, S., Nakajima, S., Ishizuka, M., Fujita, S. andKishi, R. 2006. Maternal smoking during pregnancy and genetic polymorphisms in the Ah receptor, CYP1A1 and GSTM1 affect infant birth size inJapanese subjects. Mol. Hum. Reprod., 12: 77-83.

4 ) Tanikawa, T., Ishizuka, M. and Fujita, S. 2006. Effectiveness of difethialone baits to warfarin-resistant and susceptible colonies on roof rats, Rattus rattus. Medical Entomology and Zoology., 57: 355-359.

5 ) Muzandu, K., Ishizuka, M., Sakamoto, K. Q., Shaban, Z., El, Bohi, K., Kazusaka, A. and Fujita, S. 2006. Effect of lycopene and beta-carotene on peroxynitrite-mediated cellular modifications . Toxicol . Appl . Pharmacol., 215: 330-340.

 

2005

Original articles

 

1 ) Sakai, N., Saito, K., Kim, H.S., Kazusaka, A., Ishizuka, M., Funae, Y. and Fujita, S. 2005. Importance of CYP2D3 in polymorphism of diazepam p-hydroxylation in rats. Drug Metab, Dispos., 33(11): 1657-1660.

2 ) Muzandu, K., Shaban, Z., Ishizuka, M., Kazusaka, A. and Fujita, S. 2005. Nitric oxide enhances catechol estrogen-induced oxidative stress in LNCaP cells . Free Radic Res., 39(4): 389-398.

3 ) Nikaidou, S., Ishizuka, M., Maeda, Y., Hara, Y., Kazusaka, A. and Fujita, S. 2005. Effect of components of green tea extracts, caffeine and catechins on hepatic drug metabolizing enzyme activities and mutagenic transformation of carcinogens. Jpn. J. Vet. Res., 2005. 52(4): 185-192.

4 ) Muzandu, K., El. Bohi, K., Shaban, Z., Ishizuka, M., Kazusaka, A. and Fujita, S. 2005. Lycopene and beta-carotene ameliorate catechol estrogen-mediated DNA damage. Jpn. J. Vet. Res., 52(4): 173-184.

5 ) El. Bohi, K.M., Sabik, L., Muzandu, K., Shaban, Z., Soliman, M., Ishizuka, M., Kazusaka, A. and Fujita , S. 2005. Antigenotoxic effect of Pleurotus cornucopiae extracts on the mutagenesis of Salmonella typhimurium TA98elicited by benzo [a]pyrene and oxidative DNA lesions in V79hamster lung cells . Jpn . J. Vet . Res., 52(4):163-172.

6 ) Shaban, Z., Soliman,M., El-Shazly, S., El-Bohi, K., Abdelazeez, A.,Kehelo, K., Kim, H . S. , Muzandu , K., Ishizuka, M., Kazusaka, A. and Fujita, S. 2005. AhR and PPARalpha : antagonistic effects on CYP2B and CYP3A, and additive inhibitory effects on CYP2C11. Xenobiotica., 35(1): 51-68.

7 ) Nikaidou, S., Ishizuka, M. , Maeda, Y. , Hara, Y., Kazusaka, A. and Fujita, S. 2005. Effect of catechins on mutagenesis of Salmonella typhimurium TA102 elicited by tert-butyl hydroperoxide (t-BuOOH). J. Vet. Med. Sci., 67(1): 137-138.

 

2004

Original articles

 

1 ) Shaban, Z., El-Shazly, S., Abdelhady, S., Fattouh, I., Muzandu, K., Ishizuka, M., Kimura, K., Kazusaka, A., Fujita, S. 2004. Down regulation of hepatic PPARalpha function by AhR ligand. J. Vet. Med. Sci. 66 :1377-1386.

 

2 ) Sakamoto, K.Q., Ishizuka, M., Kazusaka, A., Fujita, S. 2004. Iodine intake as a possible cause of discontinuous decline in sperm counts: a re-evaluation of historical and geographic variation in semen quality. Jpn. J. Vet. Res. 52 : 85-94.

 

3 ) Kim, H.S., Ishizuka, M., Kazusaka, A., Fujita, S. 2004. Alterations of activities of cytosolic phospholipase A2 and arachidonic acid-metabolizing enzymes in di-(2-ethylhexyl)phthalate-induced testicular atrophy. J. Vet. Med. Sci. 66 : 1119-1124.

 

4 ) Saito, K., Sakai, N., Kim, H.S., Ishizuka, M., Kazusaka, A., Fujita, S. 2004. Strain differences in diazepam metabolism at its three metabolic sites in sprague-dawley, brown norway, dark agouti, and wistar strain rats. Drug Metab. Dispos. 32 : 959-65.

 

5 ) Shaban, Z., El-Shazly, S., Ishizuka, M., Kimura, K., Kazusaka, A., Fujita, S. 2004. PPARalpha-dependent modulation of hepatic CYP1A by clofibric acid in rats. Arch. Toxicol. 78 : 496-507.

 

6 ) Saito, K., Kim, H.S., Sakai, N., Ishizuka, M., Kazusaka, A., Fujita, S. 2004. Polymorphism in diazepam metabolism in Wistar rats. J. Pharm. Sci. 93 : 1271-1278.

 

2003

Original articles

 

1 ) Kim, H.S., Saito, K., Ishizuka, M., Kazusaka, A., Fujita, S. 2003. Short period exposure to di-(2-ethylhexyl) phthalate regulates testosterone metabolism in testis of prepubertal rats. Arch Toxicol., 77, 8 : 446-51.

 

2 ) Sakamoto, K.Q., Nakai, K., Aoto, T., Yokoyama, A., Ushikoshi, R., Hirose, H., Ishizuka, M., Kazusaka, A., Fujita, S. 2003. Cytochrome p450 induction and gonadal status alteration in common carp (Cyprinus carpio) associated with the discharge of dioxin contaminated effluent to the Hikiji River, Kanagawa Prefecture, Japan. Chemosphere. 51, 6 : 491-500.

 

3 ) Ishizuka, M., Yonemoto, J., Zaha, H., Tohyama, C., Sone, H. 2003. Perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters sex-dependent expression of hepatic CYP2C11. J Biochem Mol Toxicol., 17, 5 : 278-85.

 

4 ) Hoshino, H., Fujita, S., Goto, Y., Isono, T., Tsuyoshi, I., Yasunori, S. 2003. Organochlorine compound accumulation in Steller sea lion Eumetopias jubatus migrating along the coast of Hokkaido in northern Japan. Jpn J Toxicol. 6, 1 : 1-10.

 

2002

Original articles

 

1 ) Sakamoto K. Q, Nakai, K., Aoto, T., Yokoyama, A., Ushikoshi, R., Hirose, H., Ishizuka, M., Kazusaka, A., Fujita, S. 2003. Cytochrome P450 induction and gonadal status alteration in common carp (Cyprinus carpio) associated with the discharge of dioxin contaminated effluent to the Hikiji River, Kanagawa Prefecture, Japan. Chemosphere, 51(6): 491-500.

 

2 ) Tilley, R.E., Kemp, G.D., Teramitsu, I., Hall, A. J. 2002. Isolation of two cytochrome P450 cDNAs, CYP1A1 and CYP1A2, from harp seal (Phoca groenlandica) and grey seal (Halichoerus grypus). Comp Biochem Physiol C Toxicol Pharmacol., 132(2): 181-191

 

3 ) Sakamoto, K. Q., Kunisue, T., Watanabe, M., Masuda, Y., Iwata, H., Tanabe, S., Akahori, F., Ishizuka, M., Kazusaka, A., Fujita, S. 2002. Accumulation patterns of polychlorinated biphenyl congeners and organochlorine pesticides in Steller's sea eagles and white-tailed sea eagles, threatened species, in Hokkaido, Japan. Environ Toxicol Chem. 21(4): 842-847.

 

4 ) Chiba, I., Sakakibara, A., Iwata, T. H., Ishizuka, M., Tanabe, S., Akahori, F., Kazusaka, A., Fujita, S. 2002. Hepatic microsomal cytochrome p450s and chlorinated hydrocarbons in largha and ribbon seals from Hokkaido, Japan: differential response of seal species to Ah receptor agonist exposure. Environ Toxicol Chem. 21(4): 794-806.

 

5 ) 石塚真由美、藤田正一 「化学物質による野生生物及び生態系への影響とは」化学物質と環境 2003 58:7-10

 

Publications other than original articles

 

1 ) 石塚真由美、岩田久人、藤田正一:トキシコロジー7章 環境毒性(日本トキシコロジー学会)2002(290-303)

 

2 ) 板倉隆夫、石塚真由美、藤田正一:シトクロムP450(講談社サイエンティフィク)印刷中

 

3 ) 藤田正一「臨床薬物代謝化学」(廣川書店)印刷中

 

4 ) Ishizuka, M., Yamamoto, Y., Takada, A., Kazusaka, A., Fujita, S. 2002. The loss of enzyme activities by a single amino acid substitution of a newly cloned rabbit CYP2D isozyme, CYP2D24. International Congress Series. 1223:1 21-126.

 

2001

Original articles

 

1 ) Sakamoto QK, Kunise T, Watanabe M, Masuda Y, Iwata H, Tanabe S, Akahori F, Ishizuka M, Kazusaka A, Fujita S. Accumulation patterns of polychlorinated biphenyl congeners and organochlorine pesticides in Steller’s sea eagles and White-tailed sea eagles, threatened species, in Hokkaido, Japan. Environ Toxicol Chem. 2002 Apr;21(4):842-7.

 

2 ) Chiba I, Sakakibara A, Iwata H, Ishizuka M, Tanabe S, Kazusaka A, Fujita S. Hepatic microsomal cytochrome P450s and chlorinated hydrocarbons in largha and ribbon seals from Hokkaido, Japan: Differential response of seal species to Ah receptor agonist exposure. Environ Toxicol Chem. 2002 Apr;21(4):794-806.

 

3 ) Maruyama Y, Suzuki Y, Kazusaka A, Fujita S. Uptake of the dopaminergic neurotoxin, norsalsolonol, into PC12 cells via dopamine transpoter. Archives of toxicology. 2001 75(4):209-13.

 

4 ) Teraoka H, Maruyama Y, Takehana K, Iwanaga T, Hiraga T, Fujita S, Ohta T. Ca(2+) signaling in porcine duodenal glands by muscarinic receptor activation. Am J Physiol Gastrointest Liver Physiol. 2001 280(4):G729-37.

 

5 ) Maruyama Y, Suzuki Y, Kazusaka A, Fujita S. Norsalsolinol uptake into secretory vesicles via vesicular monoamine transporter and its secretion by membrane depolarization or purinoceptor stimulation in PC12 cells. J Vet Med Sci. 2001 63(5):493-7.

 

6 ) Chiba I, Sakakibara A, Goto Y, Isono T, Yamamoto Y, Iwata H, Tanabe S, Shimazaki K, Akahori F, Kazusaka A, Fujita S. Negative correlation between plasma thyroid hormone levels and chlorinated hydrocarbon levels accumulated in seal from the coast of Hokkaido, Japan.? Environ Toxicol Chem. 2001 20(5):1092-7.

 

7 ) Fujita S, Chiba I, Ishizuka M, Hoshi H, Iwata H, Sakakibara A, Tanabe S, Kazusaka A, Masuda M, Masuda Y, Nakagawa H. P450 in wild animals as biomarker of environmental impact. Biomarkers 2001 6(1):13-25

 

8 ) Yamamoto H, Watanabe T, Mizuno H, Endo K, Fukushige J, Hosokawa T, Kazusaka A, Fujita S. The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats. Free Radic Res. 2001 34(1):69-80.

 

9 ) Yamamoto H, Watanabe T, Mizuno H, Endo K, Hosokawa T, Kazusaka A, Gooneratne R, Fujita S. In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis. Free Radic Biol Med. 2001 30(5):547-54.

 

10) Maruyama Y, Teraoka H, Iwata H, Kazusaka A, Fujita S. Inhibitory effects of endogenous dopaminergic neurotoxin, norsalsolinol on dopamine secretion in PC12 rat pheochromocytoma cells. Neurochem Int. 2001 38(7):567-572.

 

2000

Original articles

 

1 ) Chiba I, Sakakibara A, Goto Y, Isono T, Yamamoto Y, Iwata H, Tanabe S, Shimazaki K, Akahori F, Kazusaka A, Fujita S. Negative correlation between plasma thyroid hormone levels and chlorinated hydrocarbon levels accumulated in seal from the coast of Hokkaido, Japan.? (Environ Toxicol Chem. 2001 20(5):1092-7.

 

2 ) Fujita S, Chiba I, Ishizuka M, Hoshi H, Iwata H, Sakakibara A, Tanabe S, Kazusaka A, Masuda M, Masuda Y, Nakagawa H. P450 in wild animals as biomarker of environmental impact. Biomarkers 2001 6(1):13-25

 

3 ) Teramitsu I, Yamamoto Y, Chiba I, Iwata H, Tanabe S, Fujise Y, Kazusaka A, Akahori F, Fujita S. Identification of novel cytochrome P450 1A genes from five marine mammal species. Aquat Toxicol. 2000 Dec 1;51(2):145-153.

 

4 ) Yamamoto H, Watanabe T, Mizuno H, Endo K, Fukushige J, Hosokawa T, Kazusaka A, Fujita S. The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats. Free Radic Res. 2001 Jan;34(1):69-80.

 

5 ) Yamamoto H, Watanabe T, Mizuno H, Endo K, Hosokawa T, Kazusaka A, Gooneratne R, Fujita S. In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis. Free Radic Biol Med. 2001 Mar 1;30(5):547-54.

 

6 ) Maruyama Y, Teraoka H, Iwata H, Kazusaka A, Fujita S. Inhibitory effects of endogenous dopaminergic neurotoxin, norsalsolinol on dopamine secretion in PC12 rat pheochromocytoma cells. Neurochem Int. 2001 Jun 1;38(7):567-572.

 

7 ) Yoon S, Kazusaka A, Fujita S. FTIR spectroscopic and HPLC chromatographic studies of carbon tetrachloride induced acute hepatitis in rats: damage in liver phospholipid membrane. Biopolymers. 2000;57(5):267-71.

 

8 ) Yoon S, Maruyama Y, Kazusaka A, Fujita S. Application of FT-IR and ESR spectroscopic techniques to the study of CCl4-induced peroxidation in rat liver microsomes. Jpn J Vet Res. 2000 Feb;47(3-4):151-4.

 

9 ) Yoon S, Maruyama Y, Kazusaka A, Fujita S. Accumulation of diacylglycerol induced by CCl4-derived radicals in rat liver membrane and its inhibition with radical trapping reagent--FT-IR spectroscopic and HPLC chromatographic observations. Jpn J Vet Res. 2000 Feb;47(3-4):135-44.

 

1999

Original articles

 

1 ) Nakamura, A., Hirota, T., Morino, A., Imaoka, S., Funae, Y., Yamamota, Y., Tasaki, T., Masuda, M., Kazusaka, A. and Fujita, S. 1999. Cylochrome P-450 isoforms responsible for the N-demethylation an d cyclohexane-hydroxylation of NS-21. Xenobiotica, 29 : 243-252.

 

2 ) Shimamoto, Y., Tasaki, T., Kitamura, H., Hirose, K., Kazusaka, A. and Fujita, S. 1999. Decrease in hepatic CYP 2 C11 mRNA and increase in heme oxygenase activity after intracerebroventricular injection of bacterial endotoxin. J. Vet. Med. Sci.,61 : 609-613.

 

3 ) Shimamoto, Y., Kitamura, H., Iwai, M., Saito, M., Kazusaka, A. and Fujita, S. 1999. Mechanism of decresae in levels of hepatic P450 isozymes induced by intracerebral endotoxin. Arch. Toxicol . , 73 : 41-49.

 

4 ) Yamamoto, H., Hirose, K., Hayasaki, Y., Masuda, M., Kazusaka, A. and Fujita, S. 1999. Mechanism of enhanced lipid peroxidation in the liver of Long-Evance cinnamon (LEC) rats. Arch. Toxicol., 73 : 457-464.

 

5 ) Kblood, E. B. M., Miyoshi, H., Iwata, H., Kazusaka, A., Kon, Y., Handid, A. H. A., Moustafe, E. K., Ghomin, M. H. and Fu-jita, S. 1999. Effects of concurrent exposure to 3 -methylcholanthrene and vitamin A on fetal development in rats. Jpn. J. Vet. Res.,47 : 13-23.

 

6 ) Takahashi, J., Furuhata, Y., Ikeda, A., Takahashi, M., Iwata, H., Kazusaka, A. and Fujita, S. 1999. Characterization of hepatic cyiochrome P450 isozyme composition in the transgenic rat expressing low level human growth hormone. Xenobiotica, 29 : 1203-1212.

 

7 ) Kim, E. -Y., Goto, R., Iwata, H., Masuda, Y., Tanabe, S and Fujita, S. 1999. Preliminary survey of, Iead poisoning of steller's sea eagle ( Haliaeetus pelagicus) and White-tailed sea eagle (Haliaeetus albicilla) in Hokkaido, Japan. Environmental Toxicology and Chemistry, 18 : 448-451.

 

8 ) Fujita, S. 1999. Experimental use of debate in a science class. J. Higher Education and Lifelong Learning, 5 : 74-91. (in Japanese with English Summary)

 

Publications other than original articles

 

1 ) Yoon, S., Kazusaka, A. and Fujita, S. 1999. Infrared spectroscopic study on the mechanism of CC14 toxicity toward membrane phospholipids from rat liver. J. Toxicol. Sci., 24, 370

 

2 ) Maruyama, Y., Suzuki, Y., Teraoka, H., lwata, H., Kazusaka, A. and Fujita, S. 1999. Norsalsolinol, an endogeneous dopaminergic neurotoxin , inhibits dopamine secretion in PC12 cells. J. Toxicol. Sci., 24, 358

 

3 ) Chiba, I., Sakakibara, A., Iwata, H., Tanabe, S., Kazusaka, A. and Fujita, S. 1999. Seal liver P450, as a marker enzyme for marine pollution. J. Toxicol. Sci., 24, 301

 

4 ) Yoon, S., Kazusaka, A. and Fujita, S. 1999. FT-IR observation of conformational change in the rat liver phosphol-ipid with spontaneous or chemical in-duced hepatitis. Fourier Transform Spectroscopy, 12th International Conference, pp475-476

 

5 ) Sasaki, I., Kawanabe, A., Yamakawa, I., Kazusaka,A.,Yoon, S. and Fujita, S. 1999. In vivo observation of cylochrome P450 1 A isozyme reaction in liver of living rats by using fiberoptic sensor. Proceedings of 13th international conference on optical fiber sensor, Seoul, Korea

 

1998

Original articles

 

1 ) Tasaki, T., Nakamura, A., Itoh, S., Ohashi, K., Yamamoto, Y., Masuda, M.,Iwata, H., Kazusaka, A., Kamataki, T., Fujita, S.; Expression and characterization of dog CYP2D15 using baculovirus expression system. J. Biochem. 123, 162-168 (1998)

 

2 ) Ishizuka, M., Sakiyama, T., Iwata, H., Fukushima, M., Kazusaka, A., Fujita, S.; Accumulation of halogenated aromatic hydrocarbons and activities of cytochrome P450 and glutathione S-transferase in crabs (Eriocheir japonicus) from Japanese rivers. Environmental Toxicology and Chemistry 17, 1490-1498 (1998).

 

3 ) Yamamoto, Y., Tasaki, T., Nakamura, A., Iwata, H., Kazusaka, A., Gonzalezb, F. J., Fujita, S.; Molecular basis of the dark agouti rat drug oxidation polymorphism: importance of CYP2D1 and CYP2D2. Pharmacologenetics 8, 73-82 (1998).

 

4 ) Yamamoto, Y., Ishizuka, M.,Takada, A., Fujita, S.; Cloning, tissue distribution, functional expression of novel rabbit cytochrome P450 isozymes, CYP2D23 and CYP2D24. J. Biochem., 124, 503-508 (1998)

 

5 ) Tasaki, T., Iwata, H., Kazusaka, A., Fujita, S.; Regio- and stereoselectivity in propranolol metabolism by dog liver microsomes and dog CYP2D15. J. Biochem. 123, 747-751 (1998)

 

6 ) Hoshi, H., Minamoto, N., Iwata, H., Shiraki, K., Tatsukawa, R., Tanabe, S., Fujita, S., Hirai, K., Kinjyo, T.; Organochlorine pesticides and polychlorinated biphenyl congeners in wild terrestrial mammals and birds from Chubu region, Japan: Interspecies comparison of the residue levels and compositions. Chemosphere, 36, 3211-3221 (1998)

 

7 ) Ishizuka, M., Iwata, H., Hatakeyama, S., Kazusaka, A., Fujita, S.; Effects of the agrochemicals butachlor, pretiolachlor and isoprothiolaane on rat liver xenobioticmetabolizing enzymes. Xenobiotica, 11, 1029-1039 (1998)

 

8 ) Morita, K., Maeda, Y., Masuda, M., Kazusaka, A., Fujita, S.; Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Biochem. Pharmacol., 55, 1405-1411 (1998)

 

9 ) Iwata, H., Tanabe, S., Iida, T., Baba, N., Ludwig, J.P., and Tatsukawa,R; Enantioselective accumulation of alpfa-hexachlorocyclohexane in northern furseals and double-crested cormorants: Effects of biological and ecological factors in the higher trophic levels. Environ. Sci. Technol., 32, 2244-2249 (1998).

 

10) Shimamoto, Y., Kitamura, H., Hoshi, H., Kazusaka, A., Funae, Y., Imaoka, S., Saito, M., Fujita, S.; Differential alteration of microsomal cytochrome P450 levels in rat liver microsomes following intracerebral injection of bacterial lipopolysaccharide. Archive of Toxicology, 72, 492-498 (1998)

 

Publications other than original articles

 

1 ) ä‚ìcãvêl(1998) écóØê´óLã@âñëfâªçáï®ÇÃêÖåóêカë‘ånÇ÷ÇÃâe ãøÅ[ì¡Ç…É_ÉCÉIÉLÉV ÉìóÞÇ…íçñレǵǃÅ[ÅAêÖä¬ã´äwâÔéèÅA 21,407-411

 

2 ) ä‚ìcãvêl (1998) ìýï™îÂùòóêâªäwï®éøÇ…ÇÊÇÈäCê±öMì・oacute;ÞÅEíケóÞ Ç÷ÇÃêカëÃâeãøÅAäC ómÇニêカï®ÅA20,270-276

 

1997

Original articles

 

1 ) Ishizuka, M., Yoshino, S., Yamamoto, Y., Yamamoto, H., Imaoka, S., Funae, Y., Iwata, H., Masuda, M., Kazusaka, A., and Fujita, S. 1997. Pathway-selective alteration of imipramine metabolism during regeneration of male rat liver following partial hepatectomy. Xenobiotica, 27 : 923-931.

 

2 ) Maeda, Y., Morita, K., Tasaki, T., Masuda, M., Kazusaka, A., and Fujita, S. 1997. Strain differences in testosterone metabolism in Wistar and Dark Agouti rats.-A new polymorphism-. Environ. Toxicol. Pharmacol., 3 : 1-6.

 

3 ) Maeda, Y., Taira, T., Haraguchi, K., Hirose, K., Kazusaka, A., and Fujita, S. 1997. Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat. Cancer Lett., 119 : 137-141.

 

4 ) Iwata, H., Tanabe, S., Mizuno, T. and Tatsukawa, R. 1997. Bioaccumulation of butyltin compounds in marine mammals: Their tissue distribution and composition. Appl. Organomet. Chem., 11 : 257-264.

 

5 ) Guruge, K.S., Iwata, H., Tanaka, H. and Tanabe, S. 1997. Accumulation of butyltins in the liver and kidney of seabirds. Mar. Environ. Res., 44 : 191-199.

 

6 ) Tasaki, T., Nakamura, A., Itoh, S., Ohashi, K., Yamamoto, Y., Masuda, M., Iwata, H., Kazusaka, A., Kamataki, T. and Fujita, S. 1998. Expression and characterization of dog CYP2D15 using baculovirus expression system. J. Biochem., 123 : 162-168.

 

7 ) Yamamoto, Y., Tasaki, T., Nakamura, A., Iwata, H., Kazusaka, A.,Gonzalez, F. J. and Fujita, S. 1998. Molecular basis of the Dark Agouti rat drug oxidation polymorphism: Involvement of CYP2D1 and CYP2D2. Pharmacogenetics, 8 : 73-82.

 

Publications other than original articles

 

1 ) Fujita, S. 1997. Current status of university entrance examination and its impact on the education. J. Higher Education (Hokkaido Univ.), 2 : 171-179 (in Japanese).

 

2 ) Iwata, H., Watanabe, M., Tanabe, S., Masuda, Y., Masuda, M., Kazusaka, A., and Fujita, S. 1997. High level of chlorinated hydrocarbons found in Stellars sea eagles found dead in Shiretoko Peninsula. Annual Report of Shiretoko Museum, 18 : 1-7 (in Japanese).

 

3 ) Hoshi, H. 1997. A method for monitoring environmental contamination-Environmental monitoring using wild rodent's P450 as an indicator-. Jpn. J. Zoo Wild. Med., 2 : 9-12 (in Japanese).

 

1996

Original articles

 

1 ) Fujita, S., Masuda, M., Shimamoto, Y., Hoshi, H., Kariya, S., Kazusaka, A. and Suzuki, T. 1996. Effect of 3-methylcholan-threne on bunitrolol metabolism: Kinetics and immunological studies on 4-hydroxylation of bunitrolol catalyzed by two species of cytochromes P450 in rat liver microsomes. Drug Metab. Dispos., 24: 254-259.

 

2 ) Ishizuka, M., Hoshi, H., Minamoto, N., Masuda, M., Kazusaka, A. and Fujita, S. 1996. Alterations of cytochrome P450 dependent monooxygenase activities in Eriocheir japonicus in response to water pollution. Environ. Health Persp., 104: 774-778.

 

3 ) Yamamoto, Y., Nakamura, A., Tasaki, T., Umeda, S., Sugimoto, C., Imaoka, S., Funae, Y., Masuda, M., Kazusaka, A. and Fujita, S. 1996. Impaired expression in DA rats of catalytically active P450BTL, immunochemically distinguishable from P4502D1: Immunological evidence with specific anti-peptide antibodies. Biomed. Res., 17: 331-337.

 

4 ) Hatakeyama, S., Hayasaki, Y., Masuda, M., Kazusaka, A. and Fujita, S. 1996. Mechanism for mouse strain differences in the protective effect of Sudan III against the in vivo genotoxicity of 7, 12-dimethylbenz-(a)anthracene. Toxicol. Lett., 89: 231-239.

 

5 ) Tanabe, S., Kummran, P., Iwata, H., Tatsukawa, R. and Miyazaki, N. 1996. Enantiomeric ratios of alpha-hexachlorocyclohexane in blubber of small cetaceans. Mar. Pollut. Bull., 32: 27-31.

 

6 ) Kim, G. B., Lee, J. S., Tanabe, S., Iwata, H., Tatsukawa, R. and Shimazaki, K. 1996. Specific accumulation of butyltin compounds in various organs and tissues of steller sea lion (Eumetopias jubatus): Comparison with organochlorine compounds. Mar. Pollut. Bull., 32: 558-563.

 

7 ) Guruge, K. S., Tanabe, S., Iwata, H., Tatsukawa, R. and Yamagishi, S. 1996. Distribution, biomagnification, and elimination of butyltin compound residues in common cormorant (Phalacrocorax carbo) from Lake Biwa, Japan. Arch. Environ. Contam. Toxicol., 31: 210-217.

 

Publications other than original articles

 

1 ) Fujita, S. 1996. Inhibition of cytochrome P450. Jpn. J. Toxicol., 9: 149-158 (in Japanese).

 

2 ) Fujita, S. 1996. Opinions of the teaching staff of Hokkaido university on the evaluation of their lectures by students. J. Higher Education (Hokkaido Univ.), 1: 81-104 (in Japanese).

 

3 ) Fujita, S. 1996. Students' evaluation of the lectures of Hokkaido university. Tsukuba Forum, 45: 28-34 (in Japanese).

 

4 ) Kazusaka, A. 1996. Thinking about environmental science. J. Environmental Protection Center of Hokkaido University, 5: 9-12 (in Japanese).

 

5 ) Kazusaka, A. 1996. One biological reaction occurred by copper ions. Shokubai, 38: 316-317 (in Japanese).

 

6 ) Iwata, H. and Tatsukawa, R. 1996. Marine pollution by organochlorines. In: Civilization and Environment: Environmental Crisis and Modern Civilization, pp. 114-129, Ishi, H. and Numata, S. eds., Asakura Press, Tokyo (in Japanese).

 

7 ) Iwata, H., Ishizuka, M. and Fujita, S. 1996. Animal as a indicator of highly toxic organic pollutants: Availability of biomarker to detect environmental pollution. J. Vet. Med., 49: 665-669 (in Japanese).

 

8 ) Iwata, H., Tanabe, S. and Tatsukawa, R. 1996. Accumulation of organotin compounds in higher trophic animals. In: Proceedings of Otsuchi Manne Research Center Report, Vol. 21, pp. 61-62, Iwate (in Japanese).