2016

Original articles

 

1 ) Delgermurun, D., Ito, S., Ohta, T., Yamaguchi, S. and Otsuguro, K. 2016. Endogenous 5-HT outflow from chicken aorta by 5-HT uptake inhibitors and amphetamine derivatives. J. Vet. Med. Sci., 78: 71-76. (doi: 10.1292/jvms.15-0146)

 

2015

Original articles

 

1 ) Miyamoto, R., Otsuguro, K., Yamaguchi, S., and Ito, S. 2015. Neuronal regulation of hydrogen sulfide-producing enzyme cystathionine β-synthase expression in rat spinal cord astrocytes. Neurosci. Res., 97: 52-59. (doi: 10.1016/j.neures.2015.03.003)

 

2 ) Eguchi, R., Akao, S., Otsuguro, K., Yamaguchi, S. and Ito, S. 2015. Different mechanisms of extracellular adenosine accumulation by reduction of the external Ca2+ concentration and inhibition of adenosine metabolism in spinal astrocytes. J. Pharmacol. Sci., 128: 47-53. (doi: 10.1016/j.jphs.2015.04.008)

 

3 ) Otsuguro, K., Tomonari, Y., Otsuka, S., Yamaguchi, S., Kon, S. and Ito, S. 2015. An adenosine kinase inhibitor, ABT-702, inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat. Neuropharmacology, 97: 160-170. (doi: 10.1016/j.neuropharm.2015.05.035)

 

4 ) Kobayashi, T., Otsuguro, K., Yamaguchi, S. and Ito, S. 2015. Contribution of α2A-adrenoceptor subtype to effect of dexmedetomidine and xylazine on spinal synaptic transmission of mice. Eur. J. Pharmacol., 761: 321-329. (doi: 10.1016/j.ejphar.2015.06.020)

 

5 ) Ujike, A., Otsuguro, K., Miyamoto, R., Yamaguchi, S. and Ito, S. 2015. Bidirectional effects of hydrogen sulfide via ATP-sensitive K+ channels and transient receptor potential A1 channels in RIN14B cells. Eur J Pharmacol., 764: 463-470. (doi: 10.1016/j.ejphar.2015.07.029)

 

2014

Original articles

 

1 ) Yamaguchi, S. and Ishikawa, T. 2014. AHCYL2 (long-IRBIT) as a potential regulator of the electrogenic Na+-HCO3- cotransporter NBCe1-B. FEBS Lett., 588: 672-677. (doi:10.1016/j.febslet.2013.12.036)

 

2 ) Miyamoto, R., Otsuguro, K., Yamaguchi, S. and Ito, S. 2014. Contribution of cysteine aminotransferase and mercaptopyruvate sulfur transferase to hydrogen sulfide production in peripheral neurons. J. Neurochem., 130: 29-40. (doi: 10.1111/jnc.12698)

 

3 ) Yamaguchi, S., Tanimoto, A., Otsuguro, K., Hibino, H. and Ito, S. 2014. Negatively-charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity. J. Biol. Chem., 289: 35265-35282. (doi: 10.1074/jbc.M114.606087)

 

2013

Original articles

 

1 ) Iwasaki, T., Otsuguro, K., Kobayashi, T., Ohta, T. and Ito, S. 2013. Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT2A and 5-HT3 receptors. Eur. J. Pharmacol., 702: 149-157.

 

2 ) Adachi, N., Yoshida, T., Nin, F., Ogata, G., Yamaguchi, S., Suzuki, T., Komune, S., Hisa, Y., Hibino, H. and Kurachi, Y. 2013. The mechanism underlying maintenance of the endocochlear potential by the K+-transport system in the fibrocytes of the inner ear. J. Physiol., 591: 4459-4472.

 

2012

Original article

 

1 ) Kawamoto, K., Otsuguro, K., Ishizuka, M. and Ito, S. 2012. Inhibitory effects of dopamine on spinal synaptic transmission via dopamine D1-like receptors in neonatal rats. Br. J. Pharmacol., 166: 788-800.

 

Publication other than original article

 

1 ) Ito, S. 2012. Cooperative veterinary Educations with Hokkaido University and Obihiro University of Agriculture and Veterinary Medicine. J. Jpn. Vet. Med. Assoc., 65: 245-248. (in Japanese).

 

2011

Original articles

 

1 ) Miyamoto, R., Otsuguro, K. and Ito, S. 2011. Time- and concentration-dependent activation of TRPA1 by hydrogen sulfide in rat DRG neurons. Neurosci.Lett., 499: 137-142. (doi: 10.1016/j.neulet.2011.05.057) 

2 ) Otsuguro, K., Wada, M. and Ito, S. 2011. Differential contributions of adenosine to hypoxia-evoked depressions of three neuronal pathways in isolated spinal cord of neonatal rats. Br. J. Pharmacol., 164: 132-144. (doi: 10.1111/j.1476-5381.2011.01333.x) 

 

Publication other than original articles

 

1 ) Kagiyama, N. 2011. Comments on the amendment of the Law for the Humane Treatment and Management of Animals. LABIO21, 43: 6-8. (in Japanese) 

 

2010

Original articles

 

1 ) Kajihara, Y., Murakami, M., Imagawa, T., Otsuguro, K., Ito, S. and Ohta, T. 2010.Histamine potentiates acid-induced responses mediating transient receptor potential V1 in mouse primary sensory neuronsNeuroscience, 166: 292-304. (doi: 10.1016/j.neuroscience.2009.12.001)

2 ) Takahashi T., Otsuguro K., Ohta T. and Ito S. 2010. Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal ratsBr. J. Pharmacol., 161: 1806-1816. (doi 10.1111/j.1476-5381.2010.01002.x)

 

Publications other than original articles

 

1 ) Kagiyama, N. 2010. Legal standing of the 3R-Principle in the Law for the Humane Treatment and Management of Animals, and proper care and management of laboratory animals. J.Jpn.Vet.Med.Assoc., 63: 395-398. (in Japanese)

2 ) Kagiyama, N. 2010. Regulations on animal experiments in the near futute - Discussion by the Committee on Animal Welfare and Ethical Animal Experiments, the Japanese Association for Laboratory Animal Science -.LABIO21, 41: 6-10. (in Japanese) 

 

2009

Original articles

 

1 ) Ohta, T., Imagawa, T. and Ito, S. 2009. Involvement of Transient Receptor Potential Vanilloid Subtype 1 in Analgesic Action of Methyl salicylateMol. Pharmacol., 75: 307-317.

2 ) Otsuguro, K., Ban, M., Ohta, T. and Ito, S. 2009. Roles of purines in synaptic modulation evoked by hypercapnia in isolated spinal cord of neonatal rat in vitroBrit. J. Pharmacol., 156: 1167-1177.

3 ) Ogawa, T., Hashimoto, M., Niitsu, Y., Jakubowski, J.A., Tani, Y., Otsuguro, K., Asai, F. and Sugidachi, A. 2009. Effects of prasugrel, a novel P2Y12inhibitor, in rat models of cerebral and peripheral artery occlusive diseases. Eur. J. Pharmacol., 612: 29-34.

4 ) Murakami, M., Ohta, T. and Ito, S. 2009. Lipopolysaccharides enhance the action of bradykinin in enteric neurons via secretion of interleukin-1β from enteric glial cellsJ. neurosci. res., 87: 2095-2104.

5 ) Nagasaki, K., Ikoma, T., Katsuda, S., Tonegawa, T., Tanaka, J., Nakamura, T., Sato, H., Ito, S., Sasaki, N. and Agui, T. 2009. Sustained Efficacy of Erythropoietin with a Hydroxyapatite Carrier Administered in Mice. J. Vet. Med. Sci., 71: 729-736.

6 ) Nagasaki, K., Ikoma, T., Katsuda, S., Tonegawa, T., Tanaka, J., Ohyama, M., Hayashida, K., Nakamura, T., Sato, H., Ito, S., Sasaki, N. and Agui, T. 2009. Amelioration of Anemia in the ICGN Mouse, a Renal Anemia Model, with a Subcutaneous Bolus Injection of Erythropoietin Adsorbed to Hydroxyapatite MatrixJ. Vet. Med. Sci.,71: 1365-1371.

 

Publications other than original articles

 

1 ) Kagiyama, N. 2009. Promotion of laboratory animal welfare and ethical in vivo research conducted by the Japanese Society for Laboratory Animal Resources. LABIO 21, 36: 5-7. (in Japanese)

2 ) Kagiyama, N. 2009. Social understanding is indispensable for scientific and ethical animal experiments. Proceedings of the 3rd Symposium of Molecular Imaging Research Center, National Institute of Radiological Sciences, 37-38. (in Japanese)

3 ) Kagiyama, N. 2009. Perspectives of the new policies and guidelines on animal experimentation ethicsThe Japanese Journal of Animal Psychology, 59: 131-134. (in Japanese) 

 

2008

Original articles

 

1 ) Murakami M., Ohta T. and Ito S. 2008. Interleukin-1β enhances the action of bradykinin in rat myenteric neurons through up-regulation of glial B1 receptor expressionNeuroscience, 151: 222-231.

2 ) Ohta T., Imagawa T. and Ito S. 2008. Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): Tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1. J. Biol. Chem, 283: 9377-9387.

3 ) Otsuguro K., Tang J., Tang Y., Xiao R., Freichel M., Tsvilovskyy V., Ito S., Flockerzi V., Zhu M. X. and Zholos A. V. 2008. Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4, 5-bisphosphate. J. Biol. Chem, 283: 10026-10036.

4 ) Niitsu Y., Sugidachi A., Ogawa T., Jakubowski J. A., Hashimoto M., Isobe T., Otsuguro K. and Asai F. 2008. Repeat oral dosing of prasugrel, a novel P2Y12 receptor inhibitor, results in cumulative and potent antiplatelet and antithrombotic activity in several animal species. Eur. J. Pharmacol, 579: 276-282.

5 ) Ishida T., Takei R., Gautam S. H., Otsuguro K., Ohta T., Ito S., Habara Y. and Saito T. 2008. Voltage-gated channel properties of epithelial cells in porcine vomeronasal organNeurosci. Lett, 441: 277-281.

 

Publications other than original articles

 

1 ) Otsuguro K., Yasutake S., Yamaji Y., Ban M., Ohta T. and Ito S. 2008. Why does carbon dioxide produce analgesia? Alternatives to Animal Testing and Experimentation, 14: 101-106.

2 ) Kagiyama N. 2008. Guidelines and practices for ethical animal experiments. Folia Pharmacol. Jpn, 131: 187-193. (in Japanese)

3 ) Ito S. 2008.-PhD (Veterinary Sciences) (10)-Introduction of Graduate School of Veterinary Medicine in Hokkaido University. J. Jpn. Vet. Med. Assoc, 61: 13-14. (in Japanese)

4 ) Kagiyama N. 2008. Perspectives for outside verification on ethical animal experimentation conducted by pharmaceutical industries. Human science, 19: 32-34. (in Japanese)

5 ) Kagiyama N. 2008. What should we do for more social understanding on animal experiments? LABIO 21, 33: 27-29. (in Japanese)

6 ) Kagiyama N. 2008. Animal welfare and laboratory animal science. Bulletin of Gakushikai, 872: 79-84. (in Japanese)

 

2007

Original articles

 

1 ) Gautam, S. H., Otsuguro, K., Ito, S., Saito, T. and Habara, Y. 2007. T-Type Ca2+ channels mediate propagation of odor-induced Ca2+ transients in rat olfactory receptor neurons. Neuroscience, 144, 702-713.

2 ) Gautam, S. H., Otsuguro, K., Ito, S., Saito T. and Habara, Y. 2007. T-Type Ca2+ channels contribute to IBMX/forskolin-and K+-induced Ca2+ transients in porcine olfactory receptor neurons. Neurosci. Res., 57, 129-139.

3 ) Murakami, M., Ohta, T., Otsuguro, K. and Ito, S. 2007. Involvement of prostaglandin E2 derived from enteric glial cells in the action of bradykinin in cultured rat myenteric neurons. Neuroscience, 145, 642-653.

4 ) Tabo, M., Kimura, K. and Ito, S. 2007. Monophasic action potential in anaesthetized guinea pigs as a biomarker for prediction of liability for drug-induced delayed ventricular repolarization. J. Pharmacol. Toxicol. Methods, 55, 271-278.

5 ) Ohta, T., Imagawa, T. and Ito, S. 2007. Novel agonistic action of mustard oil on recombinant and endogenous porcine transient receptor potential V1 (pTRPV1) channels. Biochem. Pharmacol., 73, 1646-1656. 

 

2006

Original articles

 

1 ) Otsuguro, K., Ohta, T. and Ito, S. 2006.  Zinc modulates primary afferent fiberevoked responses of ventral roots in neonatal rat spinal cord in vitro. Neuroscience, 138: 281-291.

2 ) Ohta, T., Ikemi, Y., Murakami, M., Imagawa, T., Otsuguro, K. and Ito, S. 2006.  Potentiation of transient receptor potential V1fanctions by the activation of metabotropic5‐ HT receptors in rat primary sensory neurons. J. Physiol., 576: 809-822.

3 ) Gautam, S.H., Otsuguro, K., Ito, S., Saito, T. and Habara, Y. 2006. Intensity of odorant stimulation affects mode of Ca2+ dynamics in rat olfactory receptor neurons. Neurosci. Res., 55: 410-420.

4 ) Otsuguro, K., Yamaji, Y., Ban, M., Ohta, T. and Ito, S. 2006. Involvement of adenosine in depression of synaptic transmission during hypercapnia in isolated spinal cord of neonatal rats. J. Physiol., 574: 835-847.

5 ) Tabo, M., Nakamura, M., Kimura, K. and Ito , S. 2006. QT-RR Relationships and suitable QT correction formulas for halothane- anesthetized dogs. J. Toxicol. Sci., 31: 381-390.

6 ) Takahashi, E., Inanami, O., Ohta, T., Matsuda, A. and Kuwabara, M. 2006. Lipid raft disruption prevents apoptosis induced by 2‐chloro‐2'‐deoxyadenosine (Cladribine) in leukemia cell lines. Leuk. Res., 30: 1555-1561.

 

Publications other than original articles

 

1 ) Hashimoto, Y., Kon, Y., Okumura, M. and Ito, S. 2006. Current teaching veterinary anatomy and surgery with a minimum loss of animal life in EU countries ( in Japanese). J. Clin. Vet. Med., 24: 63-75.

 

2005

Original articles

 

2 ) Ohta T., Komatsu R., Imagawa T., Otsuguro K. & Ito S. 2005. Molecular cloning, functional characterization of the porcine transient receptor potential V1 (pTRPV1) and pharmacological comparison with endogenous pTRPV. Biochem Pharmacol, 71 173-187.

2 ) Ohta T., Kubota A., Murakami M., Otsuguro K. & Ito S. 2005. P2X2 receptors are essential for [Ca2+]i increases in response to ATP in cultured rat myenteric neurons. Am J Physiol, 298,G935-G948.

3 ) Otsuguro K., Yasutake S., Ohta T. & Ito S. 2005. Effects of opioid receptor and alpha2-adrenoceptor agonists on slow ventral root potentials and on capsaicin and formalin tests in neonatal rats. Dev Brain Res, 158,50-58.

4 ) Otsuguro K, Gautam SH, Ito S, Habara Y, & Saito T. 2005. Characterization of forskolin-induced Ca2+ signals in rat olfactory receptor neurons. J Pharmacol Sci, 97,510-518.

 

2004

Original articles

 

1 ) Ohta,T., Moroshita,M., Mori,Y. and Ito,S. 2004. Ca2+ store-independent augmentation of [Ca2+] i responses to G-protein coupled receptor activation in recombinantly TRPC5-expressed rat pheochromocytoma (PC12) cells. Neuroscience Letters.,358:161-164.

 

2 ) Maruyama,K., Ohta,T. and Ito,S. 2004. Involvement of mitochondrial Na+ -Ca2+ exchange in intracellular Ca2+ increase induced by ATP in PC12 cells. Brain Research,1013:40-50.

 

3 ) Ohta,T., Kai,T. and Ito,S. 2004. Evidence for paracrine modulation of voltage-dependent calcium channels by amperometric analysis in cultured porcine adrenal chromaffin cells. Brain Research,1030:183-192.

 

Publications other than original articles

 

1 ) Ito,S. 2004. Mercury poisoning., Drug poisoning., Paraquat poisoning., Acetaminophen poisoning., Organophosphate poisoning., Arsenic poisoning., Phenol poisoning., etc. In: Clinical aspects of feline diseases, Maede Y. ed., new ed., Dairyman, Sapporo, (in Japanese).

 

2 ) Ito,K., Ito,S., Ozaki,H., Karaki,H., Komori,S. and Shimoda,M. (Eds.) 2004.New Textbook of Veterinary Phamacology (2 nd Edition). Kindaisyuppan, Tokyo, (in Japanese).

 

3 ) Nakazato,Y. and Ito,S. 2004. Principles of drug therapeutics. In: New Textbook of Veterinary Phamacology (2 nd Edition). pp44-45, Ito,K., Ito,S., Ozaki,H., Karaki,H., Komori,S. and Shimoda,M. (Eds.)

 

4 ) Ito,s. 2004. Drugs acting on the peripheral nervous system. Ibid., chapter 1,2,3 pp48-60, chapter 5,6 pp64-68.

 

5 ) Nakazato,Y. and Ohto,T. 2004. Drugs acting on the peripheral nervous system. Ibid., chapter 7,8 pp69-74.

 

6 ) Ito,s. 2004. Drugs acting on the immune system. Ibid., pp168-171.

 

7 ) Ito,K., Ito,S., Ozaki,H., Komori,S., Shimoda,M., Hori,M., Ikeda,M., Ohta,T. and Unno,T. (Eds.) 2004. Veterinary Clinical Phamacology Data Base (VCPDB, CD-ROM). Kindaisyuppan, Tokyo, (in Japanese).

 

2003

Original articles

 

1 ) Yonekubo, K., Ohta, T. and Ito, S. 2003. Two distinct inhibitory actions of steroids on cholinoceptor-mediated secretion of catecholamine from guinea- pig adrenal medullary cells. Neurosci Lett., 337 : 89 - 92.

 

2 ) Suzuki, Y., Kondo, K., Matsumoto, Y., Zhao, B.- Q., Otsuguro, K., Maeda, T., Tsukamoto, Y., Urano, T. and Umemura, K. 2003. Dietary supplementation of fermented soybean, natto suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury rat femoral artery. Life Sci, 73: 1289 -1298

 

3 ) Niwa, K., Inanami, O., Yamamori, T., Ohta, T., Hamasu, T., and Kuwabara, M. 2003. Redox regulation of PI3K/Akt and p53 in bovine aortic endothelial cells exposed to hydrogen peroxide. Antioxidants & Redox Signaling, 5: 713 -722

 

Publications other than original articles

 

1 ) Ito. S. 2003. Education of biomedical science of veterinary medicine and the usage of animals. J. Jpn. Vet. Med. Assoc., 56, 176-179 (in Japanese)

 

2 ) Ohta, T., Kai, T., and Ito, S. 2003. Abstracts of Communications of the 45th Annual Meeting of the Japanese Society for Neurochemistry. Neurochemical Resarch, 28: 1063-1144

 

2002

Original articles

 

1 ) Kitamura, G., Ohta, T., Kai, T., Kon, Y., and Ito, S. 2002. Inhibitory effects of opioids on voltage-dependent Ca2+ channels and catecholamine secretion in cultured porcine adrenal chromaffin cells. Brain Research, 942: 11-22

 

2 ) Ohta, T., Wakade, A, R., Yonekubo, K., and Ito,S. 2002. Functional relation between caffeine-and muscarine-sensitive Ca2+stores and no Ca2+ releasing action of cyclic adenosine diphosphate-ribose in guinea-pig adrenal chromaffin cells. Neuroscience Lett. 326: 167-170

 

3 ) Ohta, T., Okamoto, E., Shimoya, M., Nakazato, Y., and Ito, S. 2002. Relaxant Mechanisms of Parathyroid Hormone in Rat Mesenteric Artery. Journal of Cardiovascular Pharmacology, 40: 554-563

 

4 ) Yonekubo, K., Ohta, T., Nakazato, Y., and Ito, S. 2002. Inhibitory effects of cortical steroids and adrenocorticotropic hormone on catecholoamine secretion in guinea-pig perfused adrenal glands. Autonomic & Autacoid Phamacol. 22: 93-101

 

5 ) Ogawa, T., Sugidachi, A., Otsuguro, K., Isobe, T., Asai, F. 2002. Platelet α-granule secretion and its modification by SC-5710A, a GPⅡb/Ⅲa antagonist Biochem. Pharmacol., 63: 1911-1918

 

2001

Original articles

 

1 ) Teraoka, H., Maruyama, Y., Takehana, K., Iwanaga, T., Hiraga, T., Fujita, S., and Ohta, T. 2001. Ca2+ signaling in porcine duodenal glands by muscarinic receptor activation. Am. J. Physiol. Gastrointest Liver Physiol 280: G729-G737

 

2 ) Kasai, Y., Ohta, T., Nakazato, Y., and Ito, S. 2001. Release of dopamine and ATP from PC12 cells treated with dexamethasone, reserpine and bafilomycin A1 J. Vet. Med. Sci .63: 367-372

 

3 ) Katori, E., Ohta, T., Nakazato, Y., and Ito, S. 2001. Vasopressin-induced contraction in the rat basilar artery in vitro Euro. Journal of Pharmacol. 416: 113-121

 

4 ) Ito, S., Ohta, T., Kasai, Y., Yonekubo, K., and Nakazato, Y. 2001. Heterogeneity of neuronal nicotinid acetylcholine receptors in 5-HT-containing chemoreceptor cells of the chicken aorta. Bri. J. of Pharmacol. 132: 1943-1940

 

5 ) Ohta, T., Wakade, A, R., Nakazato, Y., and Ito, S. 2001. Ca2+-dependent K+ current and exocytosis in responses to caffeine and muscarine on voltage -clamped guinea-pig adrenal chromaffin cells J. of Neurochem. 78: 1243-1255

 

2000

Original articles

 

1 ) Wakisaka, C., Kitamura, N., Ohta, T., Nakasato, Y., and Ito, S. 2000. Effects of pimobendan, a new cardiotonic agent, on contractile responses in single skeletal muscle fibres of the frog. Fundam.Clin.Pharmacol.14: 379-385

 

Publications other than original articles

 

1 ) 稲波修、太田利男、昆泰寛、平岡和佳子、桑原幹典:酸化ストレスと細胞内シグナル伝達 放射線科学 vol.43 No4 2000

 

1999

Original articles

 

1 ) Ito, S., Ohta, T. and Nakazato, Y. 1999. Characteristics of 5-HT-containing chemoreceptor cells of the chicken aortic body. J Physiol. (Lond. ) , 515 : 49-59.

 

2 ) Kasai, Y., Ito, S., Kitamura, N., Ohta, T. and Nakazato Y. 1999. Online measurement of adenosine triphosphate and catecholamine released from adrenal chromaffin cells. Comp. Biochem. Physiol.. PartA, 122 : 363-368.

 

3 ) Teraoka, H., Maruyama, Y., Takehana, K., Ohta, T. and Hiraga, T, 1999. Ca2+ dynamics and membrane currents in porcine duodenal glands. J Rakuno Gakuen Univ., 23 : 139-152 (in Japanese with English summary) .

 

4 ) Inanami, O., Ohta, T., Ito, S. and Kuwabara, M. 1999. Elevation of intra-cellular calcium ions is essential for the H202-induced activation of SAPK/JNK but not for that of p38 and ERK in Chinese hamster V79 cells. Antiox. Redox Signal., I : 501-508.

 

Publications other than original articles

 

1 ) Ohta, T., Ito, S. and Nakazato, Y. 1999. Ca2+-dependent outward current and exocytotic responses to caffeine in single adrenal chromaffin cells of the guinea-pig. Jpn. J Phamracol ., 79 : 62P.

 

2 ) Yonekubo, K., Ito, S., Ohta, T. and renal chromaffm cells of the guinea-pig. Jpn. J Phamracol ., 79 : 62P.

 

2 ) Yonekubo, K., Ito, S., Ohta, T. and Nakazato, Y. 1999. Effects of glucocorticoids on catecholamine secretion and membrane currents in guinea-pig adrenal chromaffin cells,. Ibid ., 123P.

 

3 ) Ito, S., Ohta, T. and Nakazato, Y. 1999. Voltage-dependent channels in 5 -HT-containing epithelioid cells isolated from chicken thoracic aorta. International Symposium on New Developments in Smooth Muscle and Endothelial Cell Signaling. Abst., pp92.

 

4 ) Ohta, T.,Yasuda, W., Hasegawa, A. Ito, S. and Nakazato, Y. 1999. Effects of tyrosine kinase inhibitors snd nonselective cation channel blockers on capacitative calcium entry in rat ileal smooth muscles. lbid ., pp93.

 

5 ) Urakawa, N., Ohga, A., Karaki, H., Ohashi, H., Nakazato, Y., Ito, K., Ito, S., and Ozaki, H. (Eds. ) 1999. New Textbook of Veterinary Phamacology. Kindaisyuppan, Tokyo, (in Japanese).

 

6 ) Nakazato, Y. 1999. Principles of drug therapeutics. In : New Textbook of Veterinary Pharmacology . pp44-45, Urakawa, N., Ohga, A., Karaki, H., Ohashi, H., Nakazato, Y., Ito, K., Ito, S., Ozaki, H. (Eds. )

 

7 ) Ito, S. 1999. Drugs acting on the peripheral nervous system. Ibid ., pp48-60, pp64 -68 .

 

8 ) Nakazato, Y. 1999. Drugs acting on the peripheral nervous system. Ibid. pp69-75.

 

9 ) Ito, S. 1999. Drugs acting on the immune system. Ibid ., pp168-171.

 

1998

Original articles

 

1 ) Kitamura, N., Ohta, T., Ito, S. and Nakazato, Y. 1998. Calcium channel current facilitation in porcine adrenal chromaffin cells. Pflügers Arch-Eur J Physiol., 435 : 781-788.

 

2 ) Nakai, K., Usuba, A., Ohta, T., Kuwabara, M., Nakazato, Y., Motoki, R. and Takahashi, T. A. 1998. Coronary vascular bed perfusion with a polyethylene glycol-modified hemoglobin-encapsulated liposome, neo red cell, in rats. Artif. Organs, 22(4) : 320-325.

 

3 ) Sugawara, T., Kitamura, N., Ohta, T., Ito, S. and Nakazato, Y. 1998. Inhibitory effects of tacrine and physostigmine on catecholamine secretion and membrane currents in guinea-pig adrenal chromaffin cells. Fundam. Clin. Pharmacol., 12 : 279-285.

 

4 ) Otsuguro, K., Ohra, T., Ito, S. and Nakazato, Y. 1998. Two types of relaxation-mediating P2 receptors in rat gastric circular muscle. Jpn. J. Pharmacol., 78 : 209-215.

 

5 ) Ohta, T., Ito, S., Kaneko, M. and Nakazato, Y. 1998. Involvement of voltage-dependent Ca2+ channels in cytosolic Ca2+ increase induced by deprivation of extracellular cations in adrenal chromaffin cells of the guinea pig. Brain Res., 814 : 99-111.

 

Publications other than original articles

 

1 ) Kanno, T., Nakazato, Y. and Kumakura, K. (Eds.) 1998. The Adrenal Chromaffin Cell : Archetype and exemplar of cellular signaling in secretory control. Hokkaido University Press, Sapporo.

 

2 ) Ohta, T., Ito, S. and Nakazato, Y. 1998. Cytosolic calcium mobilization and outward currents induced by muscarinic receptor activation in single guinea pig adrenal chromaffin cells. In The Adrenal Chromaffin Cell : Archetype and exemplar of cellular signaling in secretory control. Eds. Kanno, T., Nakazato, Y. and Kumakura, K., pp49-59, Hokkaido University Press, Sapporo.

 

3 ) Nakazato, Y. 1998. Intestinal motility : with special reference to enteric nervous system AD&S., Vol.4 : pp326-329.

 

4 ) Ohta, T., Yasuda, W., Ito, S. and Nakazato, Y. 1998. Effects of tyrosine kinase inhibitors on capacitative Ca2+ entry in rat ileal smooth muscles. Jpn. J. Pharmacol., 76 : 52P.

 

5 ) Kasai, Y., Ito, S., Kitamura, N., Ohta, T. and Nakazato, Y. 1998. Simultaneous on-line measurement of catecholamine and ATP released from adrenal chromaffin cells. Ibid. : 102P.

 

6 ) Ito, S., Ohta, T. and Nakazato, Y. 1998. Voltage-dependent channels and nicotinic receptor channels on 5-hydroxytryptamine-containing epithelioid cells in the chicken aorta. Ibid. : 237P.

 

7 ) Otsuguro, K., Ohta, T., Ito, S. and Nakazato, Y. 1998. Effects of P2-purinoceptor antagonists on purinoceptor- and pyrimidinoceptor-mediating contraction and relaxation in the rat gastric circular muscle. Naunyn-Schmiedeberg's Arch. Pharmacol., 385, Suppl.1 : R131

 

8 ) Ohta, T., Ito, S., Kaneko, M. and Nakazato, Y. 1998. Involvement of voltage-dependent Ca2+ channels in cytosolic Ca2+ increase evoked by sucrose-based Na+-free solution in adrenal chromaffin cells of the guinea pig. Ibid. : R687.

 

9 ) Kitamura, N., Ohta, T., Ito, S. and Nakazato, Y. 1998. N-type calcium channel is involved in depolarization-induced facilitation of calcium channel currents in porcine chromaffin cells. Ibid. : R692.

 

1997

Original articles

 

1 ) Sugawara,T., Ohta,T., Asano,T., Ito,S. and Nakazato,Y. 1997. Tacrine inhibits nicotinic secretory and current responses in adrenal chromaffin cells. Eur.J.Pharmacol.,319 : 123-130.

 

2 ) Kitamura,N., Ohta,T., Ito,S. and Nakazato,Y. 1997. Calcium channel subtypes in porcine adrenal chromaffin cells. Pflügers Arch-Eur.J.Physiol.,434 : 179-187.

 

3 ) Ito,S., Ohta,T., Kadota,H., Kitamura,N. and Nakazato,Y. 1997. Measurement of intracellular Na+concentration by a Na+-sensitive fluorescent dye,sodium-binding benzofuran isophthalate, in porcine adrenal chromaffin cells-usage of palytoxin as a Na+ ionophore. J.Neurosci.Meth.,75: 21-27.

 

4 ) Ito,S., Ohta,T. and Nakazato,Y. 1997. Release of 5-hydroxytryptamine by hypoxia from epithelioid cells of chicken thoracic aorta. Br.J.Pharmacol.,122 : 799-801.

 

5 ) Ito,S., Ohta,T. and Nakazato,Y. 1997. Changes in intracellular Na+concentration evoked by nicotinic receptor activation in the guinea-pig adrenal chromaffin cells. Neurosci.Lett., 238 : 111-114.

 

Publications other than original articles

 

1 ) Ohta,T., Ito,S. and Nakazato,Y. 1997. Mechanisms of rise in cytosolic calcium and outward currents activated by muscarinic receptor in single adrenal chromaffin cells of the guinea pig. 9th International Symposium on Chromaffin Cell Biology. Abst., pp56

 

2 ) Otsuguro,K., Ito,S., Ohta,T. and Nakazato,Y. 1997. Effects of extracellular adenosine 5'- triphosphate on membrane currents in guinea-pig adrenal chromaffin cells. Ibid.,pp112

 

3 ) Kitamura,N., Ohta,T., Ito,S. and Nakazato,Y. 1997. Calcium channel subtypes and facilitation of calcium channel current in porcine adrenal chromaffin cells. Ibid., pp137

 

4 ) Ito,S., Ohta,T., Kadota,H., Kitamura,N. and Nakazato,Y. 1997.Intracellular sodium ion concentration measured with sodium-binding benzofuran isophthalate in adrenal chromaffin cells.Ibid., pp138

 

5 ) Ohta,T., Ito,S. and Nakazato.Y. 1997. Characterization of calcium transient and outward current activated by muscarine in adrenal chromaffin cells of the guinea pig. The 2nd International Symposium Membrane Receptors,Signal Transduction and Drug Action. Abst., pp.73.

 

6 ) Sugawara, T., Ohta, T., Ito, S. and Nakazato, Y. 1997. Effects of tacrine and physostigmine on catecholamine release and membrane currents in guinea-pig adrenal chromaffin cell. Ibid., pp.74.

 

7 ) Ito, S., Ohta, T., Kadota, H., Kitamura, N. and Nakazato, Y. 1997. Changes in intracellular Na+concentration induced by nicotine and palytoxin in adrenal chromaffin cells. Ibid., pp.75.

 

8 ) Kitamura, N., Ohta, T., Ito, S. and Nakazato, Y. 1997. Modulation of calcium channel currents by G-protein in porcine adrenal chromaffin cells.Ibid.,pp. 80.

 

9 ) Otsuguro, K., Ohta, T., Ito, S. and Nakazato, Y. 1997. Purinoceptors and pyrimidinoceptors mediating contraction and relaxation in the rat gastric circular muscle.Ibid., pp.86.

 

10) Ito, S., Ohta, T. and Nakazato, Y. 1997. 5-hydroxytryptamine release from epithelioid cells in the chick aorta. Jpn.J.Pharmacol. 73 : 52

 

11) Ohta, T., Ito, S. and Nakazato, Y. 1997. Photoreleased inositol 1,4,5-trisphosphate-induced responses in single adrenal chromaffin cells of the guinea-pig. Ibid., pp.102.

 

12) Kitamura, N., Ohta, T., Ito, S. and Nakazato, Y. 1997. Facilitation of Ca2+channel current in porcine adrenal chromaffin cells. Ibid., pp.156

 

13) Sugawara, T., Ohta, T., Ito, S. and Nakazato, Y. 1997. Inhibitory action of tacrine and physostigmine on catecholamine secretion and membrane currents in guinea-pig adrenal chromaffin cells. Ibid., pp.195

 

1996

Original articles

 

1 ) Otsuguro, K., Ohta, T., Ito, S. and Nakazato, Y. 1996. Modulation of calcium current by ATP in guinea-pig adrenal chromaffin cells. Pflügers Arch-Eur. J. Physiol., 431: 402 407,

 

2 ) Ohta, T., Asano, T., Ito, S., Kitamura, N. and Nakazato, Y. 1996. Characterisbcs of cytosolic Ca2+ elevation induced by muscarinic receptor activation in single adrenal chromaffin cells of the guinea pig. Cell Calcium, 20: 303-314.

 

3 ) Ito, S. and Bolton, T. B. 1996. Inositol 1, 4, 5-trisphosphate-induced Ca2+-transient and outward K+ current in single smooth muscle cells of guinea pig small intestine. Jpn. J. Pharmacol., 71: 1-10.

 

4 ) Nakai, K., Ohta, T., Sakuma, I., Akama, K., Kobayashi, Y., Tokuyama, S., Kitabatake, A., Nakazato, Y. and Sekiguchi, S. 1996. Inhibition of Endothelium-dependent relaxation by hemoglobin in rabbit aortic strips: Comparison between acellular hemoglobin derivatives and cellular hemoglobins. J. Cardiovasc. Pharmacol., 28: 115-123.

 

5 ) Tabo, M., Ohta, T., Ito, S. and Nakazato, Y. 1996. Effects of external K+ on depletion-induced Ca2+ entry in rat ileal smooth muscle. Eur. J. Pharmacol., 313: 151-158.

 

6 ) Otsuguro, K., Ito S., Ohta, T. and Nakazato, Y. 1996. Influence of purines and pyrimidines on circular muscle of the rat proximal stomach. Eur. J. Pharmacol., 317: 97-105.

 

Publications other than original articles

 

1 ) Ito, S., Ohta, T. and Nakazato, Y. 1996. Characteristics of carbachol-and caffeine-induced inward currents in rat intestinal smooth muscle cells. In: Smooth Muscle Excitation, pp. 187-196, Bolton,T. B. and Tomita ,T. eds., Academic Press, London.

 

2 ) Kitamura, N., Ohta, T., Ito, S. and Nakazato, Y. 1996. Ca channel subtypes in porcine adrenal chromaffin cells. Jpn. J. Pharmacol., 71 : 67.

 

3 ) Otsuguro, K., Ito, S., Ohta, T. and Nakazato, Y. 1996. Effects of extracellular uridine 5'-tnphosphate and purinergic agonists on circular smooth muscle of the rat stomach. ibid, pp. 67.

 

4 ) Ito, S., Ohta, T. and Bolton, T. B. 1996. Ca2+-transient and outward K+ current induced by flash photolysis of caged inositol 1, 4, 5-trisphosphate in intestinal smooth muscle cell. ibid., pp. 116.

 

5 ) Ohta, T. and Ito, S. 1996. Pharmacokinetics. In: Pharmacoiogicai and Toxicotogical Experiments, Japanese Society for Veterinary Pharmacology and Toxicology. ed., pp. 37-43, Buneido, Tokyo (in Japanese).

 

6 ) Nakazato, Y. 1996. Drugs acting on cardiovascular system. ibid, pp. 81-100 (in Japanese).

 

7 ) Nakazato, Y. 1996. Drugs acting on respiratory system. ibid, pp. 105-106 (in Japanese).

 

8 ) Ito, S. 1996. Drugs acting on autonomic nervous system and smooth muscle. ibid, pp. 107-119 (in Japanese).

 

9 ) Ito, S. 1996. Drugs acting on acid secretion. ibid, pp. 120-122 (in Japanese).

 

10 ) Ohta, T. and Nakazato, Y. 1996. Behavioral toxicology. ibid, pp. 128-141 (inJapanese).