Original articles


1 ) Toda C, Santoro A, Kim JD, Diano S. POMC Neurons: From Birth to Death. Annu Rev Physiol 79, 209-236, 2017. (doi: 10.1146/annurev-physiol-022516-034110)


2 ) Kim JD, Toda C, Ramírez CM, Fernández-Hernando C, Diano S. Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity. Diabetes 66, 2102-2111, 2017. (doi: https://doi.org/10.2337/db16-1558)


3 ) Saito N, Kimura S, Miyamoto T, Fukushima S, Amagasa M, Shimamoto Y, Nishioka C, Okamoto S, Toda C, Washio K, Asano A, Miyoshi I, Takahashi E, Kitamura H. Macrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice. Biochem Biophys Rep 9, 322-329, 2017. (doi: 10.1016/j.bbrep.2017.01.009)


4 ) Shiuchi T, Toda C, Okamoto S, Coutinho EA, Saito K, Miura S, Ezaki O, Minokoshi Y. Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β2-adrenergic receptor but not by AMPK. Sci Rep 7, 15141, 2017. (doi: 10.1038/s41598-017-15548-6)


5 ) Yudasaka M, Yomogida Y, Zhang M, Tanaka T, Nakahara M, Kobayashi N, Okamatsu-Ogura Y, Machida K, Ishihara K, Saeki K, Kataura H. Near-Infrared Photoluminescent Carbon Nanotubes for Imaging of Brown Fat. Sci Rep 7, 44760, 2017. (doi: 10.1038/srep44760)


6 ) Shin W, Okamatsu-Ogura Y*, Machida K, Tsubota A, Nio-Kobayashi J, Kimura K. Near-Infrared Photoluminescent Carbon Nanotubes for Imaging of Brown Fat. Obesity 25, 417-423, 2017. (doi: 10.1002/oby.21727)


7 ) Abd Eldaim MA, Matsuoka S, Okamatsu-Ogura Y, Kamikawa A, Ahmed MM, Terao A, Nakajima KI, Kimura K. Retinoic acid modulates lipid accumulation glucose concentration dependently through inverse regulation of SREBP-1 expression in 3T3L1 adipocytes. Genes Cells 22, 568-582, 2017. (doi: 10.1111/gtc.12498)


8 ) Ito T, Yamaji D, Kamikawa A, Abd Eldaim MA, Okamatsu-Ogura Y, Terao A, Saito M, Kimura K. Progesterone dose-dependently modulates hepatocyte growth factor production in 3T3-L1 mouse preadipocytes. Endocr J 64, 777-785, 2017. (doi: 10.1507/endocrj.EJ17-0097)


9 ) Okamatsu-Ogura Y, Fukano K, Tsubota A, Nio-Kobayashi J, Nakamura K, Morimatsu M, Sakaue H, Saito M, Kimura K. Cell-cycle arrest in mature adipocytes impairs BAT development but not WAT browning, and reduces adaptive thermogenesis in mice. Sci Rep 7, 6648, 2017. (doi: 10.1038/s41598-017-07206-8)


10 ) Machida K, Okamatsu-Ogura Y, Shin W, Matsuoka S, Tsubota A,Kimura K. Role of macrophages in depot-dependent browning of white adipose tissue. J Physiol Sci 68, 601-608, 2017. (doi: 10.1007/s12576-017-0567-3)



Publications other than original articles


1 ) Okamatsu-Ogura, Y. Regulation of energy metabolism by brown adipocyte. FOOD STYLE 21 21, 60-63, 2017. (in Japanese)



Original articles


1 ) Toda C, Kim JD, Impellizzeri D, Cuzzocrea S, Liu ZW, Diano S. UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness. Cell 164, 872-883, 2016. (doi: 10.1016/j.cell.2016.02.010)


2 ) Fukano K, Okamatsu-Ogura Y, Tsubota A, Nio-Kobayashi J, Kimura K. Cold Exposure Induces Proliferation of Mature Brown Adipocyte in a ß3-Adrenergic Receptor-mediated Pathway. PLoS One 11, e0166579, 2016. (doi: 10.1371/journal.pone.0166579)


3 ) Elfeky M, Kaede R, Okamatsu-Ogura Y, Kimura K. Adiponectin Inhibits LPS-Induced HMGB1 Release through an AMP Kinase and Heme Oxygenase-1-Dependent Pathway in RAW 264 Macrophage Cells. Mediators Inflamm 2016, 5701959, 2016. (doi: 10.1155/2016/5701959)



Publications other than original articles


1 ) Okamatsu-Ogura Y. Organ specific metabolism and crosstalk of metabolic organs. In: Veterinary Biochemistry, revised ed. Yokota H, Shimizu Y, Kimura K. eds. Asakura Co. Ltd, Tokyo. pp.118-131, 2016. (in Japanese)


2 ) Kimura, K. Intercellular communications and intracellular signal transduction: Signals, Receptors, Responses, and their regulations. In: Veterinary Biochemistry, revised ed. Yokota H, Shimizu Y, Kimura K. eds. Asakura Co. Ltd, Tokyo. pp.147-168, 2016. (in Japanese)


3 ) Okamatsu-Ogura, Y. Recent advances in obesity research in dogs and cats: regulation of appetite and nutritional metabolism. J-VET 29, 8-18, 2016. (in Japanese)


4 ) Okamatsu-Ogura, Y. Brown adipose tissue: activation by food ingredients and anti-obesity effect. New Food Industry 58, 21-25, 2016. (in Japanese)



Original articles


1 ) Sakurai, Y., Okamatsu-Ogura, Y., Nakao, R., Ohnuma, A., Saito, M., Kobayashi, M. and Kimura, K. 2015. Brown adipose tissue expresses uncoupling protein 1 in newborn harbor seals (Phoca vitulina). Mar. mamm. Sci., 31: 818-827. (doi: 10.1111/mms.12193)


2 ) Okamatsu-Ogura, Y., Tsubota, A., Ohyama, K., Nogusa, Y., Saito, M. and Kimura, K. 2015. Capsinoids suppress diet-induced obesity through uncoupling protein 1-dependent mechanism in mice. J. Funct. Foods., 19: 278-287. (doi: 10.1016/j.jff.2015.09.005)



Original articles


1 ) Teramura, Y., Terao, A., Okada, Y., Tomida, J., Okamatsu-Ogura, Y. and Kimura, K. 2014. Organ-specific changes in norepinephrine turnover against various stress conditions in thermoneutral mice. Jpn. J. Vet. Res., 62: 117-127. (doi: 10.14943/jjvr.62.3.117)


2 ) Hiyoshi, H., Terao, A., Okamatsu-Ogura, Y. and Kimura, K. 2014. Characteristics of sleep and wakefulness in wild-derived inbred mice. Exp. Anim., 63: 205-213. (doi: 10.1538/expanim.63.205)


3 ) Sato, M. K., Toda, M., Inomata, N., Maruyama, H., Okamatsu-Ogura, Y., Arai, F., Ono, T., Ishijima, A. and Inoue, Y. 2014. Temperature changes in brown adipocytes detected with a bimaterial microcantilever. Biophys. J., 106: 2458-2464. (doi: 10.1016/j.bpj.2014.04.044)


Review  articles


1 )  Fukano, K. and Kimura, K. 2014. Measurement of enolase activity in cell lysates. In: Conceptual background and bioenergetic/mitochondrial aspects of oncometabolism. Methods in Enzymology, 542: 115-124 (Chapter 6). (doi: 10.1016/B978-0-12-416618-9.00006-6)



Original articles


1 ) Tanno, S., Terao, A., Okamatsu-Ogura, Y. and Kimura, K. 2013. Hypothalamic preproorexin mRNA level is inversely correlated to the non-rapid eye movement sleep level in high-fat diet-induced obese mice. Obes. Res. Clin. Pract., 7: e251-e257. (http://dx.doi.org/10.1016/j.orcp.2013.01.005)


2 ) Tsukiyama-Kohara, K., Katsume, A., Kimura, K., Saito, M. and Kohara, M. 2013. 4E-BP1 regulates the differentiation of white adipose tissue. Genes Cells, 18: 602-607. (doi: 10.1111/gtc.12059).


3 ) Okamatsu-Ogura, Y., Fukano, K., Tsubota, A., Uozumi, A., Terao, A., Kimura, K. and Saito, M. 2013. Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. PLoS One, 8: e84229. (doi: 10.1371/journal.pone.0084229).


4 ) Toda, C., Shiuchi, T., Kageyama, H., Okamoto, S., Coutinho, E. A., Sato, T., Okamatsu-Ogura, Y., Yokota, S., Takagi, K., Tang, L., Saito, K., Shioda, S. and Minokoshi, Y. 2013. Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptininduced glucose uptake in red-type skeletal muscle. Diabetes, 62: 2295-2307. (doi:10.2337/db12-1629).


5) Wang, T., Kusudo, T., Takeuchi, T., Yamashita, Y., Kontani, Y., Okamatsu, Y.,Saito, M., Mori, N. and Yamashita, H. 2013. Evodiamine inhibits insulin-stimulatedmTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improvesglucose tolerance in obese/diabetic mice. PLoS One, 8: e83264. (doi: 10.1371/journal.pone.0083264).


6) Sasaki, T., Shimpuku, M., Kitazumi, T., Hiraga, H., Nakagawa, Y., Shibata, H.,Okamatsu-Ogura, Y., Kikuchi, O., Kim, H. J., Fujita, Y., Maruyama, J., Susanti, V. Y., Yokota-Hashimoto, H., Kobayashi, M., Saito, M and Kitamura, T. 2013. Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates. Endocr. J., 60: 1117-1129. (http://dx.doi.org/10.1507/endocrj.EJ13-0333).


7) Pavlik, A., Slama, P., Knoll, A., Dufek, A., Kimura, K. and Subrt, J. 2013. Effect of missense mutation of leptin gene on serum leptin concentration and some blood metabolic parameters in Czech pied bulls. Bulgarian Journal of Agricultural Science, 19: 1425-1430.


Publications other than original articles


1 ) Okamatsu-Ogura, Y. and Kimura, K. 2013. Developmental mechanism and physiological role of brown and beige adipocytes. Bioindustry, 30: 4-10. (in Japanese).


2 ) Okamatsu-Ogura, Y. 2013. Comparative biology of Uncoupling Protein 1. The Lipid, 25: 29-35. (in Japanese).


3 ) Okamatsu-Ogura, Y. 2013. Roles of Uncoupling protein 1 in mammals. In: MoeruKassyokushibou no hushigi, pp.80-95, Saito, M. eds., NAP Ltd., Tokyo. (in Japanese).



Original articles


1 ) Shimada, K., Ohno, Y., Okamatsu-Ogura, Y., Suzuki, M., Kamikawa, A., Terao, A. and Kimura, K. 2012. Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes. Peptides34: 336-342.


2 ) Ishii, T., Fukano, K., Shimada, K., Kamikawa, A., Okamatsu-Ogura, Y., Terao, A., Yoshida, T., Saito, M. and Kimura, K. 2012. Proinsulin C-peptide activates α-enolase activity: Implications for C-peptide – cell membrane interactionJ. Biochem.152: 53-62. (doi: 10.1093/jb/mvs052).


3 ) Watanabe, A., Hirota, J., Shimizu, S., Inumaru, S. and Kimura, K. 2012. Single intramammary infusion of recombinant bovine interleukin-8 at dry-off induces the prolonged secretion of leukocyte elastase, inflammatory lactoferrin-derived peptides, and interleukin-8 in dairy cows. Vet. Med. Int., (doi:10.1155/2012/172072)



Original articles


1 ) Okamatsu-Ogura, Y., Nio-Kobayashi, J., Iwanaga, T., Terao, A., Kimura, K. and Saito M. 2011. Possible involvement of uncoupling protein 1 in appetite control by leptin. Exp. Biol. Med.236: 1274-1281. (doi:10.1258/ebm. 2011.011143) 


2 ) Shimba, S., Ogawa, T., Hitosugi, S., Ichihashi, Y., Nakadaira, Y., Kobayashi, M., Tezuka, M., Kosuge, Y., Ishige, K., Ito, Y., Komiyama, K., Okamatsu-Ogura, Y., Kimura, K. and Saito, M. 2011. Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS ONE, 6: e25231. (doi:10.1371/journal.pone.0025231) 


3 ) Yoneshiro, T., Aita, S., Matsushita, M., Okamatsu-Ogura, Y., Kameya, T., Kawai, Y., Miyagawa, M., Tsujisaki, M., Saito, M. 2011. Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans. Obesity,19: 1755-1760. (doi: 10.1038/oby.2011.125) 


Publication other than original articles


1) Kimura, K. and Kamikawa, A. 2011. Is NO-eNOS a target for C-peptide action and its protective effects on diabetic nephropathy? In: Sima AAF (ed) Diabetes and C-Peptide: Scientific and Clinical Aspects. Contemporary Diabetes, Chapter 6: pp. 55-65, Springer Science+Business Media LLC, PA. (DOI 10.1007/978-1-61779-391-2_6.) 



Original articles


1 ) Nordquist, L., Shimada, K., Ishii, T., Furuya, D.T., Kamikawa, A. and Kimura, K. 2010.Proinsulin C-peptide prevents Type-1 diabetes-induced decrease of renal Na+-K+-ATPase α1-subunit in ratsDiab. Metab. Res. Rev., 26: 193-199. (doi: 10.1002/dmrr.1071)


2 ) Abd Eldaim, M.A., Kamikawa, A., Soliman, M.M., Ahmed, M.M., Okamatsu-Ogura, Y., Terao, A., Miyamoto, T. and Kimura, K. 2010. Retinol binding protein 4 in dairy cows: its presence in colostrum and alteration in plasma during fasting, inflammation, and the peripartum periodJ. Dairy Res., 77: 27-32. (doi: 10.1017/S0022029909990276)


3 ) Abd Eldaim, M. A., Okamatsu-Ogura, Y., Terao, A., and Kimura, K. 2010. Effects of retinoic acid and hydrogen peroxide on sterol regulatory element-binding protein-1a activation during adipogenic differentiation of 3T3-L1 cellsJpn. J. Vet. Res., 58: 149-154. 


4 ) Sawada, T., Miyoshi, H., Shimada, K., Suzuki, A., Okamatsu, Y., Perfield II, J. W., Kondo, T., Nagai, S., Shimizu, C., Yoshioka, N., Greenberg, A. S., Kimura, K. and Koike, T. 2010.Perilipin overexpression in white adipose tissue induces a brown fat-like phenotypePLoS ONE, 5: e14006. (doi: 10.1371/journal.pone.0014006) 


Publications other than original articles


1 ) Terao, A. 2010. High-fat diet impairs sleep quality in miceAnn. Rep. Study of Food 23: 79-88. (in Japanese with English summary) 


2 ) Okamatsu, Y. and Saito, M. Brown Adipose Tissue. In: Karada to Ondo no Jiten, pp. 23-26, Kanosue, K., eds.,. Asakura Shoten, Tokyo. (in Japanese) 



Original articles


1 ) Ishioka, K., Omachi, A., Sasaki, N., Kimura, K., and Saito, M. 2009. Feline adiponectin: molecular structures and plasma concentrations in obese catsJ. Vet. Med. Sci.,71: 189-194.


2 ) Kamikawa, A., Ichii, O., Yamaji, D., Imao, T., Suzuki, C., Okamatsu-Ogura, Y., Terao, A., Kon, Y. and Kimura, K. 2009. Diet-induced obesity disrupts ductal development in the mammary glands of nonpregnant miceDev. Dyn., 238: 1092-1099. 


3 ) Soliman, M.M, El-Senosi, Y. A.-F., Salem, M.M., Hamid, O.M.A., and Kimura K. 2009.Role of protease inhibitors and acylation stimulating protein in the adipogenesis in 3T3-L1 cellsJ. Vet. Sci., 10: 197-201. 


4 ) Furuya, D.T., Ishii, T., Kamikawa, A., Shimada, K., Machado, U.F., Saito, M. and Kimura, K. 2009. Proinsulin C-peptide induces c-Jun N-terminal kinase 1 expression in LEII mouse lung capillary endothelial cellsJpn. J. Vet. Res., 57: 163-167. 


5 ) Saito, M., Okamatsu-Ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-Kobayashi, J., Iwanaga, T., Miyagawa, M., Kameya, T., Nakada, K., Kawai, Y., Tsujisaki, M. 2009. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposityDiabetes58: 1526-1531. 


Publications other than original articles


1 ) Kamikawa, A., Suzuki, C., Yamamoto, A. and Kimura, K. 2009. The inhibitory effects of diet-induced obesity on mammary gland development. Himman Kenkyu (Journal of Japan Society for the Study of Obesity)15: 222-224.(in Japanese).


2 ) Okamatsu, Y. and Kimura, K. 2009. PGC-1 and the regulation of energy metabolism in brown fat. Endocrinology & Diabetology 29:109-116.(in Japanese).


3 ) Kimura, K. 2009. UCP and Oxygen consumption. In: Karada to Sanso no Jiten, pp. 285-287, Research Group in Oxygen Dynamics, eds.,. Asakura Shoten, Tokyo. (in Japanese).


4 ) Terao, A. 2009. Identification of genes involved in prostaglandin D2 –induced sleep using GeneChip®Insomnia Res2009: 15-20.(in Japanese).



Original articles


1 ) Omachi, A., Matsushita, Y., Kimura, K. and Saito, M. 2008. Role of uncoupling protein 1 in the anti-obesity effect of β3-adrenergic agonist in the dog.Res. Vet. Sci,85: 214-219.

2 ) Omachi, A., Ishioka, K., Terao, A. and Kimura, K. 2008. Long-term feeding restriction in obese dogs reduces body fat and improves glucose metabolismJ. Pet Anim. Nutr11: 13-19. (in Japanese)

3 ) Ahmed, M., Kimura, K., Soliman, M., Yamaji, D., Ishioka, K., Hagiwara, K. and Saito, M. 2008. Leptin inhibits mitogen-induced proliferation of peripheral T lymphocytes from Holstein cows.Vet. J176: 361-368.

4 ) Kamikawa, A., Ishii, T., Shimada, K., Makondo, K., Inanami, O., Sakane, N., Yoshida, T., Saito, M. and Kimura, K. 2008. Proinsulin C-peptide abrogates Type-1 diabetes-induced increase of renal endothelial nitric oxide synthase in rats.Diabetes Metab. Res. Rev.24: 331-338.

5 ) Makondo, K., Kamikawa, A., Ahmed, M., Terao, A., Saito, M. and Kimura, K. 2008.Geldanamycin enhances hepatocyte growth factor stimulation of eNOS phosphorylation in endothelial cellsEur. J. Pharmacol582: 110-115.

6 ) Nishino, N., Tamori, Y., Tateya, S., Kawaguchi, T., Shibakusa, T., Mizunoya, W., Inoue, K., Kitazawa, R., Kitazawa, S., Matsuki, Y., Hiramatsu, R., Masubuchi, S., Omachi, A., Kimura, K., Saito, M., Amo, T., Ohta, S., Yamaguchi, T., Osumi, T., Cheng, J., Fujimoto, T., Nakao, H., Nakao, K., Aiba, A., Okamura, H., Fushiki, T. and Kasuga, M. 2008.FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets.J. Clin. Invest., 118: 2808-2821.

7 ) Terao, A., Huang, Z-L., Wisor, J. P., Mochizuki, T., Gerashchenko, D., Urade, Y. and Kilduff, T. S. 2008. Gene expression in the rat brain during prostaglandin D2-and adenosically-induced sleep.J. Neurochem105: 1480-1498.


Publications other than original articles


1 ) Terao, A., Haruyama, T. and Kimura, K. 2008. Roles of the hypocretin/orexins in the regulation of sleep and wakefulness. Jpn. J. Vet. Res55: 75-83.

2 ) Terao, A. 2008. Biological clock and non-rapid eye movement sleep. In:Chronobiology, Eds. Ishida, N. & Honma, K., pp.72-73, Asakura Co., Ltd., Tokyo. (in Japanese)

3 ) Okamatsu, Y. and Saito, M. 2008. Ectopic expression of UCP1 in WAT enhances leptin sensitivity.Himankenkyu14: 265-267. (in Japanese)

4 ) Okamatsu, Y. and Saito, M. 2008. Brown adipose tissue and obesity, metabolic syndrome. In: Obesity and fat energy metabolism, Eds. Kwada, T., Saito, M. and Ogawa, T., pp.63-81, Kenpakusha Co., Ltd., Tokyo. (in Japanese)

5 ) Saito, M. and Okamatsu, Y. 2008. Brown adipose tissue and adaptation to cold. Japanese Journal of Mountain Medicine,28: 7-13. (in Japanese)



Original Articles


1) Ishioka, K., Hosoya, K., Kitagawa, H., Shibata, H., Honjoh, H., Kimura, K. and Saito, M. 2007. Plasma leptin concentration in dogs: Effects of body condition score, age, gender and breeds. Res. Vet. Sci., 82: 11-15.

2) Okamatsu-Ogura, Y., Uozumi, A., Kitao, N., Kimura, K. and Saito, M. 2007. Day-night difference in β3-adrenoceptor agonist-induced energy expenditure: Contribution of brown fat thermogenesis and physical activity. Obesity Res. Clin. Pract., 1: 61-67.

3) Yamaji, D., Kamikawa, A., Soliman, M., Ito, T., Ahmed, M., Makondo, K., Watanabe, A., Saito, M. and Kimura, K. 2007. Leptin inhibits hepatocyte growth factor-induced ductal morphogenesis of bovine mammary epithelial cells. Jpn. J. Vet. Res., 54: 183-189.

4)  Ahmed, M., Kimura, K., Soliman, M., Yamaji, D., Okamatsu-Ogura, Y., Makondo, K., Inanami, O. and Saito, M. 2007. Effects of leptin and tumor necrosis factor-α on degranulation and superoxide production of polymorphonuclear neutrophils from Holstein cows. J. Vet.Med. Sci., 69: 125-131.

5)  Okamatsu-Ogura, Y., Kitao, N., Kimura, K. and Saito, M. 2007. Brown fat UCP1 is not involved in the febrile and thermogenic responses to IL-1β in mice. Am. J. Physiol. Endocrinol. Metab., 292: E1135-E1139.

6)  Ahmed, M., Shaban, Z., Yamaji, D., Okamatsu- Ogura, Y., Soliman, M., Abd Eldaim, M., Ishioka, K., Makondo, K., Saito, M. and Kimura, K. 2007. Induction of proinflammatory cytokines and caspase-1 by leptin in monocyte/macrophages from Holstein cows. J. Vet.Med. Sci., 69: 509-514.

7)  Fujimoto, W., Shiuchi, T., Miki, T., Minokoshi, Y., Takahashi, Y., Takeuchi, A., Kimura, K., Saito, M., Iwanaga, T. and Seino, S. 2007. Dmbx1 is essential in agouti-related protein action. Proc. Natl. Acad. Sci. USA, 104: 15514-15519.

8) Soliman, M., Kimura, K., Ahmed, M., Yamaji, D., Matsushita, Y., Okamatsu-Ogura, Y., Makondo, K. and Saito, M. 2007. Inverse regulation of leptin mRNA expression by shortand long- chain fatty acids in the cultured bovine adipocytes. Domest. Anim. Endocrinol., 33: 400-409.

9)  Kitao, N., Yahata, T., Matsumoto, T., Okamatasu-ogura, Y., Omachi, A., Kimura, K. and Saito, M. 2007. Molecular cloning and tissue distribution of uncoupling protein 1 (UCP1) in Plateau Pika (Ochotona dauurica). J. Vet. Med. Sci., 69: 1065-1068

10) Omachi, A., Ishioka, K., Uozumi, A., Kamikawa, A., Toda, C., Kimura, K. and Saito, M. 2007. β3-Adrenoceptor agonist AJ-9677 reduces body fat in obese beagles. Res. Vet. Sci., 83: 5-11

11) Okamatsu-Ogura, Y., Uozumi, A., Toda, C., Kimura, K., Yamashita, H. and Saito, M. 2007. Uncoupling protein 1 contributes to fatreducing effect of leptin. Obesity Res. Clin. Pract., 1: 233-241


Publications other than original articles


1) Yamaji, D., Saito, M. and Kimura, K. 2007. Role of adipokines in the mammary gland development. Himankenkyu, 13: 314-316. (in Japanese)

2) Terao, A. and Miyamoto, M. 2007. Recent and potential drugs for treatment of insomnia. Folia Pharmacol. Jpn., 129: 35-41. (in Japanese)

3) Terao, A. 2007. Identification of genes determining sleep disorder narcolepsy. Hokkaido Juishikai Zassi, 51: 393-396. (in Japanese)

4) Terao, A. 2007. Overview of pipeline hypnotics under active development. Pharmstage, 7:62-69. (in Japanese)

5) Kimura, K. 2007. Leptin. Hormone Handbook (The Japan Society for Comparative Endocrinologyed.), Nankou-do (Tokyo) (in Japanese)



Original Articles


1 ) Ishioka, K., Omachi, A., Sagawa, M., Shibata, H., Honjoh, T., Kimura, K. and Saito, M. 2006. Canine adiponectin : cDNA structure, mRNA expression in adipose tissues and reduced plasma levels in obesity. Res. Vet. Sci., 80: 127-132.

2 ) Nishii, N., Takasu, M., Ohba, Y., Maeda, S., Kitoh, K., Ohtsuka, Y., Honjoh, T. , Saito, M. and Kitagawa, H. 2006. Effects of administration of glucocorticoids and feeding status on plasma leptin concentrations in dogs. Am. J. Vet. Res., 67: 266-270.

3 ) Yamaji , D., Kimura, K., Watanabe, A. , Kon, Y., Iwanaga, T., Soliman, M. M.,Ahmed, M. M. and Saito, M. 2006. Bovine hepatocyte growth factor and its receptor c- Met : cDNA cloning and expression analysis in the mammary gland . Domest . Anim. Endocrinol., 30: 239-246.

4 ) Wang, Y., Kimura, K., Inokuma, K., Saito, M., Kontani, Y., Kobayashi, Y., Mori, N. and Yamashita, H. 2006. Potential contribution of vasoconstriction to suppression of heat loss and homeothermic regulation in UCP1‐deficient mice. Pflug. Arch. Eur. J. Physiol., 452: 363-369.

5 ) Inokuma, K., Okamatsu-Ogura, Y., Omachi , A. , Matsushita , Y. , Kimura , K. , Yamashita, H. and Saito, M. 2006.  Indispensable role of mitochondrial UCP1for antiobesity effect of β3‐adrenergic stimulation. Am. J. Physiol. Endocrinol. Metab.,  290: E1014-E1021.

6 ) Nishii, N., Nodake, H., Takasu, M., Soe, O., Ohba, Y., Maeda, S., Ohtsuka, Y., Honjoh, T., Saito, M. and Kitagawa, H. 2006. Postprandial changes in leptin concentrations of cerebrospinal fluid in dogs during development of obesity. Am. J. Vet . Res., 67:2006-2011.

7 ) Jeusette, I., Daminet, S., Nguyen, P., Shibata, H., Saito, M., Honjoh, T., Istasse, L. and Diez, M. 2006. Effect of ovariectomy and ad libitum feeding on body composition , thyroid status, ghrelin and leptin plasma concentrations in female dogs. J. Anim. Physiol. Anim. Nutr., 90: 12-18.


Publications other than original articles


1 ) Okamatsu , Y. and Saito , M. 2006. The function and differentiation of brown adipose tissue. Saibou, 38: 14-18. (in Japanese)

2 ) Okamatsu, Y. and Saito, M. 2006. Origin and differentiation of brown adipocytes. The Lipid, 17: 157-163. (in Japanese)

3 ) Okamatsu, Y. and Saito, M. 2006. Role of uncoupling protein1in the fat-reducing effect of leptin. Himankenkyu, 12:73-75. (in Japanese)

4 ) Okamatsu , Y. , Omachi , A. and Saito , M. 2006. Brown and white adipocytes : the roles in energy metabolism. Bunshisaibochiryo,  5: 28-34. (in Japanese)

5)  Okamatsu, Y. and Saito, M. 2006. Control of whole body energy metabolism by brown adipose tissue. Clinical Neuroscience, 24:914-916. (in Japanese)



Original Articles


1 ) Ishioka, K., Okumura, M., Sagawa, M., Nakadomo, F., Kimura, K. and Saito, M.  2005. Computed tomographic assessment of body fat in beagles. Vet. Radiol. Ultrasound, 46: 49-53.

2 ) Ishioka, K., Hatai, H., Komabayashi, K., Soliman, M. M., Shibata, H., Honjoh, T., Kimura, K. and Saito, M. 2005. Diurnal variations of serum leptin in dogs : effects of fasting and re-feeding. Vet . J. , 169: 85-90.

3 ) Inokuma, K., Ogura-Okamatsu, Y., Toda, C., Kimura, K., Yamashita, H. and Saito, M. 2005.  Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue. Diabetes, 54: 1385-1391.

4 ) Kontani , Y. , Wang , Y. , Kimura , K . , Inokuma, K., Saito, M., Suzuki, T.,Wang, Z., Sato, Y., Mori, N. and Yamashita, H. 2005. UCP1 deficiency increases susceptibility to diet-induced obesity with age .Aging Cell, 4: 147-155.

5 ) Shibata, H. , Akahane, R. , Honjoh, T. , Asano , M. , Mominoki , K . , Fujii , K . , Suzuki, M., Ohtaishi, N., Ishioka, K., Ahmed, M. M., Solilman, M. M., Kimura, K. and Saito, M. 2005. Seasonal changes in serum leptin of the feral raccoon(Procyon lotor) determined by canine-leptinspecific ELISA. J. Exp. Zool., 303A: 527-533.

6 ) Moore, M.C., Kimura, K., Shibata, H., Honjoh, T., Saito, M., Everett,C.A., Smith, M.S. and Cherrington, A.D. 2005. Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs. Am. J. Physiol. Endocrinol. Metab., 289: E225-E231.

7 ) Kimura, K., Niijima, A., Yoshida, R., Kitamura, T., Kamikawa,A., Furuya, D. T., Kitamura, N., Konno, A. , Nakamoto, H. , Sakane, N., Yoshida, T. and Saito, M. 2005. Proinsulin C-peptide activates vagus efferent output in rats. Peptides, 26: 2547-2553.

8 ) Jeusette, I. C., Detilleux, J., Shibata, H., Saito, M., Honjoh, T., Delobel, A., Istasse, L. and Diez, M. 2005. Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs. Res. Vet. Sci., 79: 169-175.

9 ) Knudson, J.D., Dincer, U.D., Dick, G.M., Shibata, H., Akahane, R., Saito, M. and Tune, J.D. 2005. Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction . Am. J. Physiol. Heart Circ. Physiol., 289: H1038-H1046.

10) Mominoki , K . , Morimatsu , M. , Karjalainen, M., Hohtola, E., Hissa, R. and Saito, M. 2005. Elevated plasma concentrations of haptoglobin in European brown bears during hibernation. Comp. Biochem. Physiol., 142: 472-477.


Publications other than original articles


1 ) Matsushita, Y. and Saito,M. 2005. Obesity and genes. Taiiku no kagaku, 55: 194-198. (in Japanese)

2 ) Inokuma, K., Okamatsu-Ogura, Y. and Saito, M. 2005.  UCP1 is necessary for anti -obesity effect of β3 agonist . Himankenkyu, 11: 188-190. (in Japanese)

3 ) Saito , M. 2005. Studies on the control mechanism of energy metabolism and its relation to obesity. J. Hokkaido Vet. Med. Assoc., 49: 305-307. (in Japanese)

4 ) Kimura, K. 2005. Biological effects of proinsulin C-peptide. Seikagaku, 77: 419-423. (in Japanese)

5 )  Hardie , G. and Saito, M. 2005. AMPactivated protein kinase : signal transduction mechanism and physiological roles. Adiposciences, 2: 404-413. (in Japanese)

6 ) Saito, M. 2005. Dietary control of energy dissipating UCP. Brain techno news, 110: 1-4. (in Japanese)

7 ) Saito, M. 2005.  Obesity, lifestyle-related diseases and dietary factors. Brain techno news, 110: 5-9. (in Japanese)



Original Articles


1 ) Makondo, K., Kimura, K., Kitamura, T., Yamaji, D., Bae, D, J., Shibata, H., Saito, M. 2004. Hepatocyte growth factor/scatter factor suppresses TNF-α-induced E-selectin expression in human umbilical vein endothelial cells. Biochim. Biophys. Acta, 1644: 9-15.


2 ) Nakamoto, H., Sakane, N., Kimura, K., Yoshida, T., Mochizuki, S., Ogasawara, Y., Kajiya, F. 2004. Synergistic effects of C-Peptide and insulin on coronary flow in early diabetic rats.Metabolism, 53: 335-339.


3 ) Yamaji, D., Kitamura, H., Kimura, K., Matsushita, Y., Okada, H., Shiina, T., Morimatsu, M., Saito, M. 2004. Cloning of bovine MAIL and its mRNA expression in white blood cells of Holstein cows. Vet. Immnol.

Immunopath., 98: 175-184.


4 ) Soliman, M., Okamoto, S., Kitamura, H., Kushibiki, S., Kimura, K., Saito, M. 2004. Adrenocortical responses to tumor necrosis factor-α and interferon-γ in cattle. Jpn. J. Vet. Res., 52: 95-99.


5 ) Rung-ruangkijkrai, T., Fujikura, D., Kitamura, H., Saito, M., Iwanaga, T. 2004. The expression of src-suppressed C kinase substrate(SSeCKS) and uptake of exogenous particles in endothelial and reticular cells. Arch. Histol. Cytol., 67: 135-147.


6 ) Shaban, Z., El-Shazly, S., Abdelhady, S., Fattouh, I., Muzandu, K., Ishizuka, M., Kimura, K., Kazusaka, A., Fujita, S. 2004. Down regulation of hepatic PPARα function by AhR ligand. J. Vet. Med. Sci., 66: 1377-1386.


7 ) Shaban, Z., El-Shazly, S., Ishizuka, M., Kimura, K., Kazusaka, A., Fujita, S. 2004. PPARα-dependent modulation of hepatic CYP1A by clofibric acid in rats. Arch. Toxicol, 78: 496-507.


8 ) Ohashi, A., Matsushita, Y., Shibata, H., Kimura, K., Miyashita, K., Saito, M. 2004. Conjugated linoleic acid deteriorates insulin resistance in obese/diabetic mice in association with decreased production of adiponectin and leptin. J. Nutr. Sci. Vitaminol., 50: 416-421.


Publications other than original articles


1 ) Omachi, A., Ishioka, K., Shibata, H., Honjoh, T., Kimura, K., Saito, M. 2004. Canine adiponectin: measurement of its serem/plasma concentration by ELISA and effects of obesity. Vet. Biochem., 41: 31-37. (in Japanese)


2 ) Inokuma, K., Okamatsu-Ogura, Y., Saito, M. 2004. The mechanism of energy expenditure by uncoupling protein 1 (UCP1) and its physiological role..Gendaiiryo, 36: 33-38. (in Japanese)


3 ) Matsushita, Y., Noda, S., Irie, Y., Kimura, K., Saito, M. 2004. A search for brown adipocyte-specific genes. Himankenkyu, 10: 99-100. (in Japanese)


4 ) Saito, M. 2004. Molecular mechanism of fat energy dissipation and dietary factors. J. Jpn. Soc. Metab. Clin. Nutr., 7: 229-235. (in Japanese)


5 ) Omachi, A., Saito, M. 2004. Isolation and cell culture of brown adipocytes. Adiposciences, 1: 443-447. (in Japanese)


6 ) Okamatsu-Ogura, Y., Inokuma, K. 2004. The role of uncoupling protein 1 in energy consumption. Diabetes and metabolic syndrome, 406-408. (in Japanese)



Original Articles


1 ) Kitamura, H., Matsushita, Y., Iwanaga, T., Mori, K., Kanehira, K., Fujikura, D.,Morimatsu, M., Saito, M.2003. Bacterial lipopolysaccharide-induced expression of the IkB protein MAIL in B-lymphocytes and macrophages. Arch. Histol. Cytol.,66:53-62.


2 ) Makondo, K., Kimura, K., Kitamura, T., Yamaji, D., Saito, M.2003. Hepatocyte growth factor transduces different intracellular signals in aortic and umbilical venous endothelial cells. Jpn. J. Vet. Res., 51:105-112.


3 ) Makondo, K., Kimura, K., Kitamura., N., Kitamura, T., Yamaji, D., Jung B. D.,Saito, M.2003. Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca2- and phosphoinositide 3-kinase/Akt-dependent phosphorylation in aortic endothelial cells.Biochem. J., 374:63-69.


4 ) Shibata, H., Sasaki, N., Honjoh, T., Ohishi, I.,Takiguchi, M., Ishioka, K., Ahmed, M., Soliman, M., Kimura, K., Saito, M.2003. Feline Leptin : Immunogenic and biological activities of the recombinant protein, and its measurement by ELISA. J. Vet. Med. Sci., 65:207-1211.


5 ) Kitamura, T., Kimura, K., Makondo, K., Furuya, D T., Suzuki, M., Yoshida, T., Saito, M. 2003. Proinsulin C-peptide increases nitric oxide production by enhancing mitogen-activated protein kinase-dependent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats. Diabetologia, 46:1698-1705.


Publications other than original articles


1 ) Kimura, K., Ishioka, K., Sasaki, N., Shibata, H., Honjoh, T., Ohishi, I., Saito, M.2003. Canine and feline leptin: a biomarker for quantitative assessment of obesity. J. Vet. Med., 56:43-46. (in Japanese)


2 ) Saito, M. 2003. Mechanism of energy expenditure regulation in brown adipose tissue and obesity. J. Jpn. Soc. Nutr. Food. Sci., 56:33-39. (in Japanese)


3 ) Ohashi, A. and Saito, M.2003. Uncoupling protein and energy metabolism. Nippon Rinsyo, 61:271-276. (in Japanese)


4 ) Ohashi, A., Saito, M. 2003. Conjugated linoleic acid inducse body fat loss, insulin resistance and fatty liver. Himan Kenkyu, 9:128-135. (in Japanese)


5 ) Kimura, K., Kitamura, T., Saito, M.2003. Proinsulin C-peptide:cellular signaling and action. Vet. Biochem., 40:9-16. (in Japanese)


6 ) Saito, M. 2003. Crosstalk between brain and nutrition. Nutrition, Brain and Behavior. pp1-22. Saito, M., Torii, K. and Aoyama, Y. eds., Kenpakusya, Tokyo. (in Japanese)


7 ) Saito, M. 2003. Regulation of energy expenditure and nutrition. Nutrition, Brain and Behavior. pp157-182. Saito, M., Torii, K. and Aoyama, Y. eds., Kenpakusya, Tokyo. (in Japanese)


8 ) Saito, M.2003. Roles of UCP in the regulation of energy expenditure. 124th Nihon Igakukai Symposium, 62-70. (in Japanese)



Original Articles


1 ) Sagawa, M. M., Nakadomo, F., Honjoh, T., Ishioka, K. and Saito, M. 2002. Correlation between plasma leptin concentration and body fat content in dogs. Am. J. Vet. Res., 63: 7-10.


2 ) Ishioka, K., Kanehira, K., Sasaki, N., Kitamura, H., Kimura, K. and Saito, M. 2002. Canine mitochondrial uncoupling proteins: structure and mRNA expression of three isoforms in adult beagles. Comp. Biochem. Physiol.

B, 131: 483-489.


3 ) Kitamura, H., Okita, K., Fujikura, D., Mori, K., Iwanaga, T. and Saito, M. 2002. Induction of src-suppressed C kinase substrate (SSeCKS) in vascular endothelial cells by bacterial lipopolysaccharide. J. Histochem. Cytochem., 50: 245-255.


4 ) Ishioka, K., Soliman, M., Sagawa, M., Nakadomo, F., Shibata, H., Honjoh, T., Hashimoto, A., Kitamura, H., Kimura, K. and Saito, M. 2002. Experimental and clinical studies on plasma leptin in obese dogs. J. Vet. Med. Sci., 64: 349-353.


5 ) Takahashi, N., Kawada, T., Goto, T., Yamamoto, T., Taimatsu, A., Matsui, N., Kimura, K., Saito, M., Hosokawa, M., Miyashita, K. and Fushiki, T. 2002. Dual action of isoprenols from herbal medicines on both PPARγ and PPARα in 3T3-L1 adiopocytes and HepG2 hepatocytes. FEBS Lett., 514: 315-322.


6 ) Kitamura, H., Kanehira, K., Shiina, T., Morimatsu, M., Jung, B. D., Akashi, S. and Saito, M. 2002. Bacterial lipopolysaccharide induces mRNA expression of an IκB MAIL through toll-like receptor 4. J. Vet. Med. Sci., 64: 419-422.


7 ) Kitamura, T., Kimura, K., Jung, B. D., Makondo, K., Sakane, N., Yoshida, T. and Saito, M. 2002. Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells. Biochem. J., 366: 737-744.


8 ) Soliman, M., Ishioka, K., Yoshida, R., Komabayashi, K., Hatai, H., Matsui, Y., Hirai, T., Katagiri, S., Takahashi, Y., Kawakita, Y., Abe, H., Kitamura, H., Kimura, K. and Saito, M. 2002. Serum leptin levels during the periparturient period in cows. J. Vet. Med. Sci., 64: 1053-1056.


9 ) Soliman, M., Ishioka, K., Kimura, K. Kushibiki, S. and Saito, M. 2002. Plasma leptin responses to lipopolysaaccharide and tumor necrosis factor α in cows. Jpn. J. Vet. Res., 50: 107-114.


10) Takada, K., Kitamura, H., Takiguchi, M., Saito, M. and Hashimoto, A. 2002. Cloning of canine 21-hydroxylase gene and its polymorphic analysis as a candidate gene for congenital adrenal hyperplasia-like syndrome in Pomeranians. Res. Vet. Sci., 73: 159-163.


11) Ishioka, K., Soliman, M. M., Okumura, M., Sagawa, M., Shibata, H., Honjoh, T., Kitamura, H., Kimura, K. and Saito, M. 2002. Effects of fish oil feeding on obesity and UCP expression in dogs. Vet. Biochem., 39: 31-38. (in Japanese with English summary)


12) Ishioka, K., Soliman, M. M., Honjoh, T., Shibata, H., Kimura, K. and Saito, M. 2002. Dexamethasone increases serum leptin concentration. Vet. J., 164: 295-297.


13) Nagase, I. and Saito, M. 2002. Up-regulation of UCP by long-chain fatty acids in L6 myotubes. Himankenkyu (J. Jpn. Soc. Study Obesity), 8: 75-79. (in Japanese)


14) Fujimoto, W., Suzuki, M., Kimura, K. and Iwanaga, T. 2002. Cellular expression of the gut chitinase in the stomach of frogs Xenopus laevis and Rana catesbeiana. Biomed. Res., 23: 91-99.


Publications other than original articles


1 ) Saito, M. 2002. Molecular mechanism of energy expenditure. Bio Clinica, 17: 139-143. (in Japanese)


2 ) Ohashi, A. and Saito, M. 2002. Energy metabolism and uncoupling protein. Medical Science Digest, 28: 487-491. (in Japanese)


3 ) Ishioka, K., Sagawa, M., Morooka, T., Niiyama, M. and Saito, M. 2002. Evaluation of obesity. SA Medicine, 4: 12-20. (in Japanese)


4 ) Noda, S., Irie, Y., Kimura, K. and Saito, M. 2002. Energy metabolism and brown adipocyte. Pharma Medica, 20: 61-67. (in Japanese)



Original Articles


1 ) Morooka, T., Niiyama, M., Uchida, E., Uemura, M., Miyoshi, K. and Saito, M. 2001. Measurement of the back fat layer in beagles for estimation of obesity using two-dimensional ultrasonography. J. Small Anim. Pract. 42: 56-59.


2 ) Iwai, M., Cui, T. X., Kitamura, H., Saito, M. and Shimazu, T. 2001. Increased secretion of tumor necrosis factor and interleukin-6 from isolated, perfused liver of rats after partial hepatectomy. Cytokine 13: 60-64.


3 ) Murase, T., Kondo, H., Hase, T., Tokimitsu, I. and Saito, M. 2001. Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates. Biochim. Biophys. Acta 1530: 15-22.


4 ) Nakamura, Y., Nagase, I., Asano, A., Sasaki, N., Yoshida, T., Umekawa, T., Sakane, N. and Saito, M. 2001. β3-Adrenergic agonist up-regulates uncoupling proteins 2 and 3 in skeletal muscle of the mouse. J. Vet. Med. Sci. 63: 309-314.


5 ) Asano, A., Irie, Y. and Saito, M. 2001. Isoform-specific regulation of vascular endothelial growth factor (VEGF) family mRNA expression in cultured mouse brown adipocytes. Mol. Cell. Endocrinol. 174: 71-76.


6 ) Kitamura, T., Kimura, K., Jung, B. D., Makondo, K., Okamoto, S., Canyas, X., Sakane, N., Yoshida, T. and Saito, M. 2001. Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein. Biochem. J. 355: 123-129.


7 ) Ishikawa, I., Kitamura, H., Kimura, K. and Saito, M. 2001. Brain interleukin-1 is involved in blood interleukin-6 response to immobilization stress in rats. Jpn. J. Vet. Res. 49: 19-25.


8 ) Shiroshita, N., Musashi, M., Sakurada, K., Kimura, K., Tsuda, Y., Ota, S., Iwasaki, H., Miyazaki, T., Kato, T., Miyazaki, H., Shimosaka, A. and Asaka, M. 2001. Involvement of protein kinase C-ε in signal transduction of thrombopoietin in enhancement of interleukin-3-dependent proliferation of primitive hematopoietic progenitors. J. Pharmacol. Exp. Ther. 297: 868-875.


9 ) Nagase, I., Yoshida, T. and Saito, M. 2001. Up-reguration of uncoupling proteins by β-adrenergic stimulation in L6 myotubes. FEBS Lett. 494: 175-180.


10) Okamoto, S., Kimura, K. and Saito, M. 2001. Anorectic effect of leptin is mediated by hypothalamic corticotropin-releasing hormone, but not by urocortin, in rats. Neurosci. Lett. 307: 179-182.


11) Sasaki, N., Shibata, H., Honjoh, T, Kimura, K., Saito, M. and Ohishi, I. 2001. cDNA cloning of feline leptin and its mRNA expression in adipose tissue. J. Vet. Med. Sci. 63: 1115-1120.


12) Soliman, M., Abdelhady, S., Fattouh, I., Ishioka, K., Kitamura, H., Kimura, K. and Saito, M. 2001. No alteration in serum leptin during acute endotoxemia in sheep. J. Vet. Med. Sci. 63: 1143-1145.


13) Abe, H., Kawakita, Y., Kodate, K. and Saito, M. 2001. Postnatal development of glucose transporter proteins in bovine skeletal muscle and adipose tissue. J. Vet. Med. Sci. 63: 1071-1075.


14) Shiina, T., Morimatsu, M., Kitamura, H., Ito, T., Kidou, S., Matsubara, K., Matsuda, Y., Saito, M. and Syuto, B. 2001. Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene. Immunogenetics 53: 649-655.


15) Konno, A., Ahn, J.-S., Kitamura, H., Hamilton, M. J., Gebe, J. A., Aruffo, A. and Davis, W. C. 2001. Tissue distribution of CD6 and CD6 ligand in cattle: expression of the CD6 ligand (CD166) in the autonomic nervous system of cattle and the human. J. Leukoc. Biol. 69: 944-950.


16) Ishioka, K., Shibata, H., Honjo, T., Sagawa, M., Nakadomo, F., Kimura, K. and Saito, M. 2001. Enzyme-linked immunosorbent assay of canine leptin and increased serum concentrations in obese beagles. Vet. Biochem. 38: 35-41.(in Japanese with English summary)


Publications other than original articles


1 ) Kitamura, H., Jung, B. D., Kimura, K. and Saito, M. 2001. Interaction of immune cytokines and the sympathetic nervous system: mechanisms of hepaic cytokine induction in stress situations. Auton Nerv. Sys. 38: 234-241. (in Japanese)


2 ) Irie, Y. and Saito, M. 2001. Ectopic expression of UCP1 in white adipose tissue. Himankenkyu 1: 63-65. (in Japanese)


3 ) Saito, M. 2001. UCP family and lipid energy metabolism. Therap. Res. 22: 1200-1204. (in Japanese)


4 ) Ishioka, K. and Saito, M. 2001. Obesity in dogs: novel methods for diagnosis. SA Medicine 3: pp55-64. (in Japanese)


5 ) Saito, M. and Ohashi, A. 2001. Mitochondrial uncoupling protein as a target of pharmacotherapy for obesity. Folia Pharmacol. Jpn. 118: 327-333. (in Japanese)


6 ) Ohashi, A. and Saito, M. 2001. Uncoupling protein, obesity and glucose metabolism. Diabetes J. 29: 103-110. (in Japanese)



Original Articles


1 ) Okamoto, S., Irie, Y., Ishikawa, I., Kimura, K. and Saito, M. 2000. Central leptin suppresses splenic lymphocyte functions through activation of the corticotropin-releasing hormone-sympathetic nervous system. Brain Res. 855 : 192-197.


2 ) Iwase, M., Kimura, K., Komagome, R., Sasaki, N., Ishioka, K., Honjoh, T. and Saito, M. 2000. Sandwich enzyme-linked immunorbent assay of canine leptin. J. Vet. Med. Sci. 62 : 207-209.


3 ) Jung, B. D., Kimura, K., Kitamura, H., Makondo, K., Kanehira, K. and Saito, M. 2000. Sympathetic activation of hepatic and splenic IL-1β mRNA expression during oscillation stress in the rat. J. Vet. Med. Sci. 62 : 409-413.


4 ) Jung, B. D., Kimura, K., Kitamura, H., Makondo, K., Okita, K., Kawasaki, M. and Saito, M. 2000. Norepinephrine stimulates interleukin-6 mRNA expression in primary cultured rat hepatocytes. J. Biochem. 127 : 205-209.


5 ) Iwase, M., Kimura, K., Sasaki, N., Komagome, R., Ishioka, K., Morimatsu, M., Murakami, T. and Saito, M. 2000. Canine leptin: cDNA cloning, expression and activity of recombinant protein. Res. Vet. Sci. 68 : 109-114


6 ) Soliman, M. M., Okamoto, S., Kitamura, H., Kimura, K. and Saito, M. 2000. Neuroendocrine and metabolic responses to recombinant interferon-γ in cattles. Proceeding of the international veterinary cytokine and vaccine conference. : 294-297.


7 ) Kimura, K., Sasaki, N., Asano, A., Mizukami, J., Kayahashi, S., Kawada, T., Fushiki, T., Morimatsu, M., Yoshida, T. and Saito, M. 2000. Mutated human β3-adrenergic receptor (Trp64Arg) lowers the response to β3-adrenergic agonists in transfected 3T3-L1 preadipocytes. Horm. Metab. Res. 36 : 91-96.


8 ) Komagome, R., Kimura, K. and Saito, M. 2000. Postnatal changes in Rho and Rho-related proteins in the mouse brain. Jpn. J. Vet. Res. 47 : 127-133.


9 ) Kitamura, H., Kanehira, K., Okita, K., Morimatsu, M. and Saito, M. 2000. MAIL, a novel nuclear IκB protein that potentiates LPS-induced IL-6 protein. FEBS Lett. 485 : 53-56.


10) Okamoto, S., Kimura, K., Kitamura, T., Canas, X., Yoshida, T. and Saito, M. 2000. Proinsulin C peptide obviates sympathetically mediated suppression of splenic lymphocyte activity in rats. Diabetologia 43 : 1512-1517.


11) Jung, B. D., Kimura, K., Kitamura, H. and Saito, M. 2000. Sympathetic regulation of hepatic interleukin expression during non-invasive stress. Animal Biochemistry 36 (2) : 21-28. (in Japanese with English summary)


12) Ishioka, K., Kanehira, K., Kitamura, H., Sasaki, N., Kimura, K. and Saito, M. 2000. Canine uncoupling proteins: cDNA cloning and tissue distribution. Veterinary Biochemistry 37 (2) : 57-64. (in Japanese with English summary)


Publications other than original articles


1 ) Saito, M. 2000. An obsity-related gene UCP. Yakuji-nippo 9237 : 22. (in Japanese)


2 ) Kimura, K. 2000. Role of prostanoid in hepatic glycogenolysis. Zoukikanryu-jikken-kouza : 39-42. (in Japanese)


3 ) Nagase, I. and Saito, M. 2000. Energy metabolism and obesity. The Lipid 11 : 468-473. (in Japanese)


4 ) Saito, M. 2000. Role of UCP in energy exoenditure. Diabetes Frontier 11 : 812-816. (in Japanese).


5 ) Kitamura, H., Terao, A, and Saito, M. 2000. Neuroregulatory actions of inflammatory cytokines. Handbook of biomimetics(Nagata, Y. eds.) NTS Tokyo : pp752-757. (in Japanese).


6 ) Kitamura, H., Morimatsu, M. and Saito, M. 2000. Stress and immunity : an general view of interactions between nervous endocrine, and immune systems. Karada-no-naka-kara-stress-wo-miru. (Nihon-hikaku-naibunnpitsu-gakkai eds.) Tokyo : pp93-121. (in Japanese)



Original Articles


1 ) Irie, Y., Asano, A., Canas, X., Nikami, H., Aizawa, S. and Saito, M. 1999. Immortal brown adipocytes from p53-knockout mice Differentiation and expression of uncoupling proteins. Biochem. Biophys. Res. Commun., 255 : 221-225.


2 ) Asano,A., Kimura, K. and Saito, M. 1999. Cold-induced mRNA expression of angiogenic factors in rat brown adipose tissue. J Vet. Med. Sci.. 61 : 403-409.


3 ) Shimamoto, Y., Kitamura, H., Iwai, M., Saito, M., Kazusaka, A. and Fujita, S. 1999. Mechanism of decrease in levels of hepatic P450 isozymes induced by intracerebral endotoxin : independence from sympathetic nervous and adrenocortical systems. Arch Toxicol ., 73 : 41-49.


4 ) Kltamura, P. H.,Yanase, H., Kitamura, H. and lwanaga, T. 1999. Unique localization of protein gene product 9. 5 in type B synoviocyies in the joints of the horse. J Histochem. Cytochem. , 47 : 343-351.


5 ) Shimamoto, Y., Tasaki, T., Kitamura, H., Hirose, K., Kazusaka, A. and Fujita, S. 1999. Decrease in hepatic CYP 2 C11 mRNA and increase in heme oxygenase activity after intracerebroventricular injection of bacterial endotoxin. J Vet. Med. Sci., 61 : 609-613.


6 ) White, B. H., Kimura, K. and Sidhu, A. 1999. Inhibition of hormonally induced inositol triphosphate production in transfected GH 4 C I cells : A novel role for the D- 5 subtype of the dopamine receptor. Neuroendocrinology , 69 : 209-216.


7 ) Sidhu, A., Olde, B., Humblot, N., Kimura, K. and Gardner, N. 1999. Regulation of human D- I dopamine receptor function and gene expression in SK-N-MC neuro-blastoma cells. Neuroscience, 91 : 537-547.


8 ) Komagome, R., Shuto, B., Moriishi, K., Kimura, K. and Saito, M. 1999. Neuronal and glial differentiation of neuroblastoma and glioma cell lines by Rho inhibitory exoenzyme C3. Neuropathology. 19 : 288-293.


9 ) Kimura, K., Jung, B. D., Kanehira, K., Irie, Y., Canas, X. and Saito, M. 1999. Induction of uncoupling protein (UCP) 2 in primary cultured hepatocytes. FEBS Lett . , 457 : 75-79.


10) Yoshida, T., Sakane, N., Umekawa, T., Kogure, A., Kondo, M., Kumamoto, K., Kagawa, T., Nagase, I. and Saito, M. 1999. Nicotine induces uncoupling protein I in white adipose tissue of obese mice. Int. J Obesity, 23 : 570-575.


11) Nagase, I., Yoshida, S., Canas, X., Irie, Y., Kimura, K., Yoshida, T. and Saito, M. 1999. Up-regulation of uncoupling protein 3 by thyroid hormone, peroxisome proliferator-activated receptor ligands and 9 -cis retinoic acid in L 6 myotubes. FEBS Lett., 461 : 319-322.


Publications other than original articles


1 ) Irie,Y. and Saito, M. 1999. Brown adipocytes and UCP family. Molecular Medicine, 36 : 264-270 (in Japanese) .


2 ) Kitamura, H. and Saito, M. 1999. Molecuar and cellular biology of brain. ( 2 ) Isolation of novel genes using the RAP-PCR technique. Neuroscience Experimental Manual. (K. Honma. and K. Fukushima. eds. ) Hokkaido Univ. Sapporo : 61-66 (in Japanese) .


3 ) Nagase, I. and Saito, M. 1999. UCP3. Himan-Kenkyu, 5 : 48-50 (in Japanese).


4 ) Irie, Y. and Saito, M. 1999. Mitochondorial uncoupling protein family and energy metabolism, obesity. Kagaku-to-seibutsu, 37 : 514-520 (in Japanese) .


5 ) Saito, M. 1999. Himan UPDATE, Uncoupling protein UCP. Mebio. 16 Supplement. Multiple Risk Factor Syndrome, 3 : 122-128 (in Japanese).



Original Articles


1 ) Kimura,K., Moriyama,M., Nishisako,M., Kannan,Y., Shiota,M., Sakurada,K., Musashi,M. and Sugano,T. 1998. Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. J. Biochem., 123 : 142-149.


2 ) Yoshida,T., Umekawa,T., Kumamoto,K., Sakane,N., Kogure,A., Kondo,M., Wakabayashi,Y., Kawada,T., Nagase,I. and Saito,M. 1998. β3-adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers. Am. J. Physiol., 274 ( Endocrinol. Metab. 37) : E469-E475.


3 ) Sasaki,N., Uchida,E., Niiyama,M., Yoshida,T. and Saito,M. 1998. Anti-obesity effects of selective agonists to the β3-adrenergic receptor in dogs. 1. The presence of canine β3-adrenergic receptor and in vivo lipomobilization by Its agonists. J. Vet. Med. Sci., 60 (4) : 459-463.


4 ) Sasaki,N., Uchida,E., Niiyama,M., Yoshida,T. and Saito,M. 1998. Anti-obesity effects of selective agonists to the β3-adrenergic receptor in dogs. 2. Recruitment of adiposity after chronic treatment with a β3-adrenergic agonist. J. Vet. Med. Sci., 60 (4) : 465-469.


5 ) Kitamura,H., Okamoto,S., Shimamoto,Y., Morimatsu,M., Terao,A. and Saito,M. 1998. Central IL-1 differentially regulates peripheral IL-6 and TNF synthesis. Cell. Mol. Life Sci., 54 : 282-287.


6 ) Kimura,K., Moriyama,M., Nishisako,M., Kannan,Y., Shiota,M. and Sugano,T. 1998. Endotoxin modulates arachidonic acid-induced glycogenolysis in the perfused rat liver. Horm. Metab. Res., 30 : 178-181.


7 ) Abe,H., Kawakita,Y., Miyashige,T., Morimatsu,M. and Saito,M. 1998. Comparison of amino acid sequence of the C-terminal domain of insulin-responsive glucose transporter (GLUT4) in livestock mammals. J. Vet. Med. Sci., 60 (6) : 769-771.


8 ) Sidhu,A., Kimura,K., Uh,M., White,B.H., and Patel,S. 1998. Multipule coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz. J. Neurochem., 70 : 2459-2467.


9 ) Terao,A., Matsumura,H. and Saito,M. 1998. Interleukin-1 induces slow-wave sleep at the prostaglandin D2-sensitive sleep-promoting zone in the rat brain. J. Neurosci., 18 (16) : 6599-6607.


10) Shimamoto,Y., Kitamura,H., Hoshi,H., Kazusaka,A., Funae,Y., Imaoka,S., Saito,M. and Fujita,S. 1998. Differential alterations in levels of hepatic microsomal cytochrome P450 isozymes following intracerebroventricular injection of bacterial lipopolysaccharide in rats. Arch. Toxicol., 72 : 492-498.


11) Li,Y-Q., Kobayashi,M., Yuan,L., Wang,J., Matsushita,K., Hamada,J-I., Kimura,K., Yagita,H., Okumura,K. and Hosokawa,M. 1998. Protein kinase C mediates the signal for interferon-γ mRNA expression in cytotoxic T cells after their adhesion to laminin. Immunology, 93 : 455-461.


12) Sakane,N., Yoshida,T., Umekawa,T., Kogure,A., Kondo,M., Nakamura,Y., Sasaki,N., Asano,A. and Saito,M. 1998. Acute and chronic regulation of ob mRNA levels by β3-adrenoceptor agonists in obese yellow KK mice. Endocrine J., 45 (5) : 647-651.


13) Terao,A., Matsumura,H., Yoneda,H. and Saito,M. 1998. Enhancement of slow-wave sleep by tumor necrosis factor-α is mediated by cyclooxygenase-2 in rats. Neuroreport, 9 : 3791-3796.


14) Okamoto,S., Ishikawa,I., Kimura,K. and Saito,M. 1998. Potent suppressive effects of urcortin on splenic lymphocyte activity in rats. Neuroreport, 9 : 4035-4039.


Publications other than original articles


1 ) Saito,M. 1998. Obesity, sympathetic nerve, and adipocyte β3-adrenoceptor. Brain Science, 20 : 41-48 ( in Japanese).


2 ) Saito,M. 1998. Uncoupling protein family : molecular structure and physiological roles. Igakunoayumi, 184 : 578-581 ( in Japanese).


3 ) Okamoto,S.,Ishikawa,I. and Saito,M. 1998. Effects of ginsenosides on the stress-induced immunosuppression. The Ginseng Review, 24 : 108-111 ( in Japanese).


4 ) Saito,M. 1998. Mitochondrial uncoupling protein as a thermogenic molecule. Seikagaku, 70 : 212-216 ( in Japanese).


5 ) Kimura,K. and Saito,M. 1998. Brown adipose tissue and β3-adrenergic receptor. The Lipid, 9 : 253-258 ( in Japanese).


6 ) Asano,A. and Saito,M. 1998. The physiological role of uncoupling protein family. Endocrinology & Diabetology, 6 (3) : 260-266 ( in Japanese).


7 ) Saito,M. 1998. Structure and function of uncoupling protein (UCP). Igakunoayumi, 185. 9 : 596-599 ( in Japanese).


8 ) Saito,M. 1998. Energy metabolism and uncoupling protein. Diabetes Frontier, 9 (4) : 405-414 ( in Japanese).


9 ) Saito,M. 1998. Brown adipocyte and uncoupling protein. Journal of Clinical Sciences, 34 (8) : 1043-48 ( in Japanese).



Original Articles


1 ) Asano, A., Morimatsu, M., Nikami, H., Yoshida, T. & Saito, M. : Adrenergic activation of vascular endothelial growth factor mRNA expression in rat brown adipose tissue: implication in cold-induced angiogenesis. Biochem. J. 328: 179-183, 1997.


2 ) Sharan, S.K., Morimatsu, M., Albrecht, U., Lim, D.-S., Regel, E., Dinh, C., Sands, A., Eichele, G., Hasty, P. & Bradley, A.: Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca 2. Nature 386: 804-810, 1997.


3 ) Kitamura, H., Konno, A., Morimatsu, M., Jung, B.-D., Kimura, K., & Saito, M.: Immobilization stress increases hepatic IL-6 expression in mice. Biochem. Biophys. Res. Commun.238: 707-711, 1997.


4 ) Abe, H., Morimatsu, M., Nikami, H., Miyasghige, T. & Saito, M.: Molecular cloning and mRNA expression of the bovine insulin-responsive glucose transporter (GLUT 4). J. Anim. Sci. 75: 182-188, 1997.


5 ) Umekawa, T., Yoshida, T., Sakane, N., Saito, M., Kumamoto, K. & Kondo, M.: Anti-obesity and anti-diabetic effects of CL316,243, a highly specific b3-adrenoceptor agonist, in Otsuka Long-Evans tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur. J. Endocrinol. 136: 429-437, 1997.


6 ) Sidhu, A., & Kimura, K.: A novel regulation of expression of the a-subunit of the G stimulatory protein by dopamine via D1 dopamine receptors. J. Neurochem. 68: 187-194, 1997.


7 ) Sela, S., White, B.H., Uh, M., Kimura, K., Patel, S. & Sidhu, A.: Dysfunctional D1A receptor-G-protein coupling in proximal tubules of spontaneously hypertensive rats is not due to abnormal G-proteins. J. Hypertension. 15: 259-267, 1997.


8 ) Sidhu, A., Uh, M., Sela, S., White, B. H., Kimura, K. & Patel, S.: Molecular and structural differences between rat brain D-1 and renal DA-1 dopamine receptors. Neurosci. Res.29: 1-8, 1997.


Publications other than original articles


1 ) Sasaki, N., Asano, A. & Saito, M.: Obesity and Thermogenesis: UCP as a target molecule. Himan Kenkyu 3:60-62, 1997 (in Japanese).


2 ) Asano, A. & Saito, M.: The characteristics, proliferation and differentiation of brown adipocytes. Gendai Iryo 29: 977-983,1997 (in Japanese).


3 ) Saito, M.: Uncoupling protein family and regulation of energy expenditure. Hissu-Aminosan Kenkyu 150: 12-18, 1997 (in Japanese).


4 ) Sasaki, N., Asano, A. & Saito, M.: Characteristics of brown adipocytes. Saishin Igaku 52: 1093-1100, 1997 (in Japanese).


5. Saito, M.: Function of brown adiptocytes and its regulation. Mebio 14 (11): 22-28, 1997 (in Japanese).



Original articles


1 ) Nikami, H., Shimizu, Y., Sumida, M., Minokoshi, Y.,Yoshida, T., Saito, M. and Shimazu, T. 1996. Expression of ,ァ3-adrenoceptor and stimulation of glucose transport by β3-agonists in brown adipocyte primary culture. J. Biochem., 119: 120-125.


2 ) Saito, M. and Okamoto, S. 1996. Effects of red ginseng on stress-induced immunosuppression. The Ginseng Rev., 21: 7-11 (in Japanese with English summary).


3 ) Sasaki, N., Uchida, E., Niiyama, M. and Saito, M. 1996. Anti-obesity effect of an adipocyte-specific adrenergic receptor agonist in dogs. Anim. Biochem., 33: 13-18 (in Japanese with English summary).


4 ) Kitamura, H., Okamoto, S., Shimamoto, Y., Terao, A., Morimatsu, M. and Saito, M. 1996. Peripheral IL-6 and TNF expression induced by brain IL-1: new aspect of the acute phase response in liver. In: Liver Innervation, pp. 213-219, Shimazu, T., ed., John Libbey & Company Ltd., London.


5 ) Mominoki, K., Morimatsu, M., Hohtola, E., Kaqalainen, M., Hissa, R. and Saito, M. 1996. Seasonal variation of blood haptoglobin level in brown bears. In: Adaptation to the Cotd: Tenth Internationat Hibernation Symposium, pp 367-372, Geiser. F., Hulbert, A. J. and Nicol, S. C., eds., Univ. New England Press, Armidale.


6 ) Asano, A., Nikami, H., Morimatsu, M. and Saito, M. 1996. Vascular endothelial growth factor in brown adipose tissue: role in angiogenesis during tissue growth after cold exposure. ibid, pp. 299-303.


7 ) Moriyama, M., Makiyama, I., Shiota, M., Uesugi, K., Kannan, Y., Ohta, M., Kimura, K. and Sugano, T. 1996. Decreased ureagenesis from alanine, but not from ammonia and glutamme, in the perfused rat liver after partial hepatectomy. Hepatology, 23: 1584-1590.


8 ) Nagase, I., Yoshida, T., Kumamoto, K., Umekawa, T., Sakane, N., Nikami, H., Kawada. T. and Saito, M. 1996. Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic ァ3-adrenergic agonist. J. Clin. Invest., 97: 2898-2904.


9 ) Mominoki, K., Tsurga, H., Morimatsu, M. and Saito, M. 1996. Seasonal variations of blood haptoglobin level of brown bears in Japan. Comp. Biochem. Physiol., 114A: 349-353.


10) Sasaki, N., Uchida, E., Niiyama, M. and Saito, M. 1996. Anti-obesity effect of an adrenergic agonist activating lipid metabolism in dogs. J. Anim. Clin. Res. Found., 5: 1-14 (in Japanese).


11) Kobayashi, M., Nikami, H., Morimatsu, M. and Saito, M. 1996. Expresssion and localization of insulin-regulatable glucose transporter (GLUT 4) in rat brain. Neurosci. Lett., 213: 103-106.


12) Kimura, K., Hamada, M., Moriyama, M., Kannan, Y., Shiota, M., Sakuraba, K., Musashi, M. and Sugano, T. 1996. Phorbol ester, but not endotoxin, desensitizes mannan-induced glycogenolysis in the perfused rat liver. J. Biochem., 120: 488-493.


13) Okamoto, S., Ibaraki,K., Hayashi, S. and Saito, M. 1996. Ventromedial hypothalamus suppresses splenic Iymphocyte activity through sympathetic innervation. Brain Res., 739: 308-313.


Publications other than original articles.


1 ) Sasaki, N. and Saito, M. 1996. Regulation of energy balance and obesity. Diagnosis and Treatment, 84: 987-992 (in Japanese).


2 ) Okamoto, S., Terao, A., Morimatsu, M. and Saito, M. 1996. Suppression of splenic lymphocyte activities by ventromedial hypothalamic stimulation: Role of sympathetic nervous system. In: Discussions on Future Direction in Psychoneuroimmunoiogy and Cancer, pp. 74-77, Sendo, F. and Herberman, R. B., eds., Nishimura Co. Ltd., Nigata.


3 ) Saito, M. and Sasaki, N. 1996. Uncoupling-protein and ァ3-adrenergic receptor in brown adipocyte. Exp. Med., 14: 40-45 (in Japanese).


4 ) Abe, H., Morimatsu, M. and Saito, M. 1996. Glucose metabolism and glucose transporters in cattle. Anim. Biochem., 33: 1-10 (in Japanese).


5 ) Saito, M. 1996. Interaction between immune and neuro-endocrine system. In: Immunology of Animals, pp. 228 235, Onuma, M., Onodera. and Yamanouchi, K., eds., Buneido Shuppan, Tokyo.