Original articles


1 ) Sakurai, Y., Okamatsu-Ogura, Y., Nakao, R., Ohnuma, A., Saito, M., Kobayashi, M. and Kimura, K. 2015. Brown adipose tissue expresses uncoupling protein 1 in newborn harbor seals (Phoca vitulina). Mar. mamm. Sci., 31: 818-827. (doi: 10.1111/mms.12193)


2 ) Okamatsu-Ogura, Y., Tsubota, A., Ohyama, K., Nogusa, Y., Saito, M. and Kimura, K. 2015. Capsinoids suppress diet-induced obesity through uncoupling protein 1-dependent mechanism in mice. J. Funct. Foods., 19: 278-287. (doi: 10.1016/j.jff.2015.09.005)



Original articles


1 ) Teramura, Y., Terao, A., Okada, Y., Tomida, J., Okamatsu-Ogura, Y. and Kimura, K. 2014. Organ-specific changes in norepinephrine turnover against various stress conditions in thermoneutral mice. Jpn. J. Vet. Res., 62: 117-127. (doi: 10.14943/jjvr.62.3.117)


2 ) Hiyoshi, H., Terao, A., Okamatsu-Ogura, Y. and Kimura, K. 2014. Characteristics of sleep and wakefulness in wild-derived inbred mice. Exp. Anim., 63: 205-213. (doi: 10.1538/expanim.63.205)


3 ) Sato, M. K., Toda, M., Inomata, N., Maruyama, H., Okamatsu-Ogura, Y., Arai, F., Ono, T., Ishijima, A. and Inoue, Y. 2014. Temperature changes in brown adipocytes detected with a bimaterial microcantilever. Biophys. J., 106: 2458-2464. (doi: 10.1016/j.bpj.2014.04.044)


Review  articles


1 )  Fukano, K. and Kimura, K. 2014. Measurement of enolase activity in cell lysates. In: Conceptual background and bioenergetic/mitochondrial aspects of oncometabolism. Methods in Enzymology, 542: 115-124 (Chapter 6). (doi: 10.1016/B978-0-12-416618-9.00006-6)



Original articles


1 ) Tanno, S., Terao, A., Okamatsu-Ogura, Y. and Kimura, K. 2013. Hypothalamic preproorexin mRNA level is inversely correlated to the non-rapid eye movement sleep level in high-fat diet-induced obese mice. Obes. Res. Clin. Pract., 7: e251-e257. (http://dx.doi.org/10.1016/j.orcp.2013.01.005)


2 ) Tsukiyama-Kohara, K., Katsume, A., Kimura, K., Saito, M. and Kohara, M. 2013. 4E-BP1 regulates the differentiation of white adipose tissue. Genes Cells, 18: 602-607. (doi: 10.1111/gtc.12059).


3 ) Okamatsu-Ogura, Y., Fukano, K., Tsubota, A., Uozumi, A., Terao, A., Kimura, K. and Saito, M. 2013. Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. PLoS One, 8: e84229. (doi: 10.1371/journal.pone.0084229).


4 ) Toda, C., Shiuchi, T., Kageyama, H., Okamoto, S., Coutinho, E. A., Sato, T., Okamatsu-Ogura, Y., Yokota, S., Takagi, K., Tang, L., Saito, K., Shioda, S. and Minokoshi, Y. 2013. Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptininduced glucose uptake in red-type skeletal muscle. Diabetes, 62: 2295-2307. (doi:10.2337/db12-1629).


5) Wang, T., Kusudo, T., Takeuchi, T., Yamashita, Y., Kontani, Y., Okamatsu, Y.,Saito, M., Mori, N. and Yamashita, H. 2013. Evodiamine inhibits insulin-stimulatedmTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improvesglucose tolerance in obese/diabetic mice. PLoS One, 8: e83264. (doi: 10.1371/journal.pone.0083264).


6) Sasaki, T., Shimpuku, M., Kitazumi, T., Hiraga, H., Nakagawa, Y., Shibata, H.,Okamatsu-Ogura, Y., Kikuchi, O., Kim, H. J., Fujita, Y., Maruyama, J., Susanti, V. Y., Yokota-Hashimoto, H., Kobayashi, M., Saito, M and Kitamura, T. 2013. Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates. Endocr. J., 60: 1117-1129. (http://dx.doi.org/10.1507/endocrj.EJ13-0333).


7) Pavlik, A., Slama, P., Knoll, A., Dufek, A., Kimura, K. and Subrt, J. 2013. Effect of missense mutation of leptin gene on serum leptin concentration and some blood metabolic parameters in Czech pied bulls. Bulgarian Journal of Agricultural Science, 19: 1425-1430.


Publications other than original articles


1 ) Okamatsu-Ogura, Y. and Kimura, K. 2013. Developmental mechanism and physiological role of brown and beige adipocytes. Bioindustry, 30: 4-10. (in Japanese).


2 ) Okamatsu-Ogura, Y. 2013. Comparative biology of Uncoupling Protein 1. The Lipid, 25: 29-35. (in Japanese).


3 ) Okamatsu-Ogura, Y. 2013. Roles of Uncoupling protein 1 in mammals. In: MoeruKassyokushibou no hushigi, pp.80-95, Saito, M. eds., NAP Ltd., Tokyo. (in Japanese).



Original articles


1 ) Shimada, K., Ohno, Y., Okamatsu-Ogura, Y., Suzuki, M., Kamikawa, A., Terao, A. and Kimura, K. 2012. Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes. Peptides34: 336-342.


2 ) Ishii, T., Fukano, K., Shimada, K., Kamikawa, A., Okamatsu-Ogura, Y., Terao, A., Yoshida, T., Saito, M. and Kimura, K. 2012. Proinsulin C-peptide activates α-enolase activity: Implications for C-peptide – cell membrane interactionJ. Biochem.152: 53-62. (doi: 10.1093/jb/mvs052).


3 ) Watanabe, A., Hirota, J., Shimizu, S., Inumaru, S. and Kimura, K. 2012. Single intramammary infusion of recombinant bovine interleukin-8 at dry-off induces the prolonged secretion of leukocyte elastase, inflammatory lactoferrin-derived peptides, and interleukin-8 in dairy cows. Vet. Med. Int., (doi:10.1155/2012/172072)



Original articles


1 ) Okamatsu-Ogura, Y., Nio-Kobayashi, J., Iwanaga, T., Terao, A., Kimura, K. and Saito M. 2011. Possible involvement of uncoupling protein 1 in appetite control by leptin. Exp. Biol. Med.236: 1274-1281. (doi:10.1258/ebm. 2011.011143) 


2 ) Shimba, S., Ogawa, T., Hitosugi, S., Ichihashi, Y., Nakadaira, Y., Kobayashi, M., Tezuka, M., Kosuge, Y., Ishige, K., Ito, Y., Komiyama, K., Okamatsu-Ogura, Y., Kimura, K. and Saito, M. 2011. Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS ONE, 6: e25231. (doi:10.1371/journal.pone.0025231) 


3 ) Yoneshiro, T., Aita, S., Matsushita, M., Okamatsu-Ogura, Y., Kameya, T., Kawai, Y., Miyagawa, M., Tsujisaki, M., Saito, M. 2011. Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans. Obesity,19: 1755-1760. (doi: 10.1038/oby.2011.125) 


Publication other than original articles


1) Kimura, K. and Kamikawa, A. 2011. Is NO-eNOS a target for C-peptide action and its protective effects on diabetic nephropathy? In: Sima AAF (ed) Diabetes and C-Peptide: Scientific and Clinical Aspects. Contemporary Diabetes, Chapter 6: pp. 55-65, Springer Science+Business Media LLC, PA. (DOI 10.1007/978-1-61779-391-2_6.) 



Original articles


1 ) Nordquist, L., Shimada, K., Ishii, T., Furuya, D.T., Kamikawa, A. and Kimura, K. 2010.Proinsulin C-peptide prevents Type-1 diabetes-induced decrease of renal Na+-K+-ATPase α1-subunit in ratsDiab. Metab. Res. Rev., 26: 193-199. (doi: 10.1002/dmrr.1071)


2 ) Abd Eldaim, M.A., Kamikawa, A., Soliman, M.M., Ahmed, M.M., Okamatsu-Ogura, Y., Terao, A., Miyamoto, T. and Kimura, K. 2010. Retinol binding protein 4 in dairy cows: its presence in colostrum and alteration in plasma during fasting, inflammation, and the peripartum periodJ. Dairy Res., 77: 27-32. (doi: 10.1017/S0022029909990276)


3 ) Abd Eldaim, M. A., Okamatsu-Ogura, Y., Terao, A., and Kimura, K. 2010. Effects of retinoic acid and hydrogen peroxide on sterol regulatory element-binding protein-1a activation during adipogenic differentiation of 3T3-L1 cellsJpn. J. Vet. Res., 58: 149-154. 


4 ) Sawada, T., Miyoshi, H., Shimada, K., Suzuki, A., Okamatsu, Y., Perfield II, J. W., Kondo, T., Nagai, S., Shimizu, C., Yoshioka, N., Greenberg, A. S., Kimura, K. and Koike, T. 2010.Perilipin overexpression in white adipose tissue induces a brown fat-like phenotypePLoS ONE, 5: e14006. (doi: 10.1371/journal.pone.0014006) 


Publications other than original articles


1 ) Terao, A. 2010. High-fat diet impairs sleep quality in miceAnn. Rep. Study of Food 23: 79-88. (in Japanese with English summary) 


2 ) Okamatsu, Y. and Saito, M. Brown Adipose Tissue. In: Karada to Ondo no Jiten, pp. 23-26, Kanosue, K., eds.,. Asakura Shoten, Tokyo. (in Japanese) 



Original articles


1 ) Ishioka, K., Omachi, A., Sasaki, N., Kimura, K., and Saito, M. 2009. Feline adiponectin: molecular structures and plasma concentrations in obese catsJ. Vet. Med. Sci.,71: 189-194.


2 ) Kamikawa, A., Ichii, O., Yamaji, D., Imao, T., Suzuki, C., Okamatsu-Ogura, Y., Terao, A., Kon, Y. and Kimura, K. 2009. Diet-induced obesity disrupts ductal development in the mammary glands of nonpregnant miceDev. Dyn., 238: 1092-1099. 


3 ) Soliman, M.M, El-Senosi, Y. A.-F., Salem, M.M., Hamid, O.M.A., and Kimura K. 2009.Role of protease inhibitors and acylation stimulating protein in the adipogenesis in 3T3-L1 cellsJ. Vet. Sci., 10: 197-201. 


4 ) Furuya, D.T., Ishii, T., Kamikawa, A., Shimada, K., Machado, U.F., Saito, M. and Kimura, K. 2009. Proinsulin C-peptide induces c-Jun N-terminal kinase 1 expression in LEII mouse lung capillary endothelial cellsJpn. J. Vet. Res., 57: 163-167. 


5 ) Saito, M., Okamatsu-Ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-Kobayashi, J., Iwanaga, T., Miyagawa, M., Kameya, T., Nakada, K., Kawai, Y., Tsujisaki, M. 2009. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposityDiabetes58: 1526-1531. 


Publications other than original articles


1 ) Kamikawa, A., Suzuki, C., Yamamoto, A. and Kimura, K. 2009. The inhibitory effects of diet-induced obesity on mammary gland development. Himman Kenkyu (Journal of Japan Society for the Study of Obesity)15: 222-224.(in Japanese).


2 ) Okamatsu, Y. and Kimura, K. 2009. PGC-1 and the regulation of energy metabolism in brown fat. Endocrinology & Diabetology 29:109-116.(in Japanese).


3 ) Kimura, K. 2009. UCP and Oxygen consumption. In: Karada to Sanso no Jiten, pp. 285-287, Research Group in Oxygen Dynamics, eds.,. Asakura Shoten, Tokyo. (in Japanese).


4 ) Terao, A. 2009. Identification of genes involved in prostaglandin D2 –induced sleep using GeneChip®Insomnia Res2009: 15-20.(in Japanese).



Original articles


1 ) Omachi, A., Matsushita, Y., Kimura, K. and Saito, M. 2008. Role of uncoupling protein 1 in the anti-obesity effect of β3-adrenergic agonist in the dog.Res. Vet. Sci,85: 214-219.

2 ) Omachi, A., Ishioka, K., Terao, A. and Kimura, K. 2008. Long-term feeding restriction in obese dogs reduces body fat and improves glucose metabolismJ. Pet Anim. Nutr11: 13-19. (in Japanese)

3 ) Ahmed, M., Kimura, K., Soliman, M., Yamaji, D., Ishioka, K., Hagiwara, K. and Saito, M. 2008. Leptin inhibits mitogen-induced proliferation of peripheral T lymphocytes from Holstein cows.Vet. J176: 361-368.

4 ) Kamikawa, A., Ishii, T., Shimada, K., Makondo, K., Inanami, O., Sakane, N., Yoshida, T., Saito, M. and Kimura, K. 2008. Proinsulin C-peptide abrogates Type-1 diabetes-induced increase of renal endothelial nitric oxide synthase in rats.Diabetes Metab. Res. Rev.24: 331-338.

5 ) Makondo, K., Kamikawa, A., Ahmed, M., Terao, A., Saito, M. and Kimura, K. 2008.Geldanamycin enhances hepatocyte growth factor stimulation of eNOS phosphorylation in endothelial cellsEur. J. Pharmacol582: 110-115.

6 ) Nishino, N., Tamori, Y., Tateya, S., Kawaguchi, T., Shibakusa, T., Mizunoya, W., Inoue, K., Kitazawa, R., Kitazawa, S., Matsuki, Y., Hiramatsu, R., Masubuchi, S., Omachi, A., Kimura, K., Saito, M., Amo, T., Ohta, S., Yamaguchi, T., Osumi, T., Cheng, J., Fujimoto, T., Nakao, H., Nakao, K., Aiba, A., Okamura, H., Fushiki, T. and Kasuga, M. 2008.FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets.J. Clin. Invest., 118: 2808-2821.

7 ) Terao, A., Huang, Z-L., Wisor, J. P., Mochizuki, T., Gerashchenko, D., Urade, Y. and Kilduff, T. S. 2008. Gene expression in the rat brain during prostaglandin D2-and adenosically-induced sleep.J. Neurochem105: 1480-1498.


Publications other than original articles


1 ) Terao, A., Haruyama, T. and Kimura, K. 2008. Roles of the hypocretin/orexins in the regulation of sleep and wakefulness. Jpn. J. Vet. Res55: 75-83.

2 ) Terao, A. 2008. Biological clock and non-rapid eye movement sleep. In:Chronobiology, Eds. Ishida, N. & Honma, K., pp.72-73, Asakura Co., Ltd., Tokyo. (in Japanese)

3 ) Okamatsu, Y. and Saito, M. 2008. Ectopic expression of UCP1 in WAT enhances leptin sensitivity.Himankenkyu14: 265-267. (in Japanese)

4 ) Okamatsu, Y. and Saito, M. 2008. Brown adipose tissue and obesity, metabolic syndrome. In: Obesity and fat energy metabolism, Eds. Kwada, T., Saito, M. and Ogawa, T., pp.63-81, Kenpakusha Co., Ltd., Tokyo. (in Japanese)

5 ) Saito, M. and Okamatsu, Y. 2008. Brown adipose tissue and adaptation to cold. Japanese Journal of Mountain Medicine,28: 7-13. (in Japanese)



Original Articles


1) Ishioka, K., Hosoya, K., Kitagawa, H., Shibata, H., Honjoh, H., Kimura, K. and Saito, M. 2007. Plasma leptin concentration in dogs: Effects of body condition score, age, gender and breeds. Res. Vet. Sci., 82: 11-15.

2) Okamatsu-Ogura, Y., Uozumi, A., Kitao, N., Kimura, K. and Saito, M. 2007. Day-night difference in β3-adrenoceptor agonist-induced energy expenditure: Contribution of brown fat thermogenesis and physical activity. Obesity Res. Clin. Pract., 1: 61-67.

3) Yamaji, D., Kamikawa, A., Soliman, M., Ito, T., Ahmed, M., Makondo, K., Watanabe, A., Saito, M. and Kimura, K. 2007. Leptin inhibits hepatocyte growth factor-induced ductal morphogenesis of bovine mammary epithelial cells. Jpn. J. Vet. Res., 54: 183-189.

4)  Ahmed, M., Kimura, K., Soliman, M., Yamaji, D., Okamatsu-Ogura, Y., Makondo, K., Inanami, O. and Saito, M. 2007. Effects of leptin and tumor necrosis factor-α on degranulation and superoxide production of polymorphonuclear neutrophils from Holstein cows. J. Vet.Med. Sci., 69: 125-131.

5)  Okamatsu-Ogura, Y., Kitao, N., Kimura, K. and Saito, M. 2007. Brown fat UCP1 is not involved in the febrile and thermogenic responses to IL-1β in mice. Am. J. Physiol. Endocrinol. Metab., 292: E1135-E1139.

6)  Ahmed, M., Shaban, Z., Yamaji, D., Okamatsu- Ogura, Y., Soliman, M., Abd Eldaim, M., Ishioka, K., Makondo, K., Saito, M. and Kimura, K. 2007. Induction of proinflammatory cytokines and caspase-1 by leptin in monocyte/macrophages from Holstein cows. J. Vet.Med. Sci., 69: 509-514.

7)  Fujimoto, W., Shiuchi, T., Miki, T., Minokoshi, Y., Takahashi, Y., Takeuchi, A., Kimura, K., Saito, M., Iwanaga, T. and Seino, S. 2007. Dmbx1 is essential in agouti-related protein action. Proc. Natl. Acad. Sci. USA, 104: 15514-15519.

8) Soliman, M., Kimura, K., Ahmed, M., Yamaji, D., Matsushita, Y., Okamatsu-Ogura, Y., Makondo, K. and Saito, M. 2007. Inverse regulation of leptin mRNA expression by shortand long- chain fatty acids in the cultured bovine adipocytes. Domest. Anim. Endocrinol., 33: 400-409.

9)  Kitao, N., Yahata, T., Matsumoto, T., Okamatasu-ogura, Y., Omachi, A., Kimura, K. and Saito, M. 2007. Molecular cloning and tissue distribution of uncoupling protein 1 (UCP1) in Plateau Pika (Ochotona dauurica). J. Vet. Med. Sci., 69: 1065-1068

10) Omachi, A., Ishioka, K., Uozumi, A., Kamikawa, A., Toda, C., Kimura, K. and Saito, M. 2007. β3-Adrenoceptor agonist AJ-9677 reduces body fat in obese beagles. Res. Vet. Sci., 83: 5-11

11) Okamatsu-Ogura, Y., Uozumi, A., Toda, C., Kimura, K., Yamashita, H. and Saito, M. 2007. Uncoupling protein 1 contributes to fatreducing effect of leptin. Obesity Res. Clin. Pract., 1: 233-241


Publications other than original articles


1) Yamaji, D., Saito, M. and Kimura, K. 2007. Role of adipokines in the mammary gland development. Himankenkyu, 13: 314-316. (in Japanese)

2) Terao, A. and Miyamoto, M. 2007. Recent and potential drugs for treatment of insomnia. Folia Pharmacol. Jpn., 129: 35-41. (in Japanese)

3) Terao, A. 2007. Identification of genes determining sleep disorder narcolepsy. Hokkaido Juishikai Zassi, 51: 393-396. (in Japanese)

4) Terao, A. 2007. Overview of pipeline hypnotics under active development. Pharmstage, 7:62-69. (in Japanese)

5) Kimura, K. 2007. Leptin. Hormone Handbook (The Japan Society for Comparative Endocrinologyed.), Nankou-do (Tokyo) (in Japanese)



Original Articles


1 ) Ishioka, K., Omachi, A., Sagawa, M., Shibata, H., Honjoh, T., Kimura, K. and Saito, M. 2006. Canine adiponectin : cDNA structure, mRNA expression in adipose tissues and reduced plasma levels in obesity. Res. Vet. Sci., 80: 127-132.

2 ) Nishii, N., Takasu, M., Ohba, Y., Maeda, S., Kitoh, K., Ohtsuka, Y., Honjoh, T. , Saito, M. and Kitagawa, H. 2006. Effects of administration of glucocorticoids and feeding status on plasma leptin concentrations in dogs. Am. J. Vet. Res., 67: 266-270.

3 ) Yamaji , D., Kimura, K., Watanabe, A. , Kon, Y., Iwanaga, T., Soliman, M. M.,Ahmed, M. M. and Saito, M. 2006. Bovine hepatocyte growth factor and its receptor c- Met : cDNA cloning and expression analysis in the mammary gland . Domest . Anim. Endocrinol., 30: 239-246.

4 ) Wang, Y., Kimura, K., Inokuma, K., Saito, M., Kontani, Y., Kobayashi, Y., Mori, N. and Yamashita, H. 2006. Potential contribution of vasoconstriction to suppression of heat loss and homeothermic regulation in UCP1‐deficient mice. Pflug. Arch. Eur. J. Physiol., 452: 363-369.

5 ) Inokuma, K., Okamatsu-Ogura, Y., Omachi , A. , Matsushita , Y. , Kimura , K. , Yamashita, H. and Saito, M. 2006.  Indispensable role of mitochondrial UCP1for antiobesity effect of β3‐adrenergic stimulation. Am. J. Physiol. Endocrinol. Metab.,  290: E1014-E1021.

6 ) Nishii, N., Nodake, H., Takasu, M., Soe, O., Ohba, Y., Maeda, S., Ohtsuka, Y., Honjoh, T., Saito, M. and Kitagawa, H. 2006. Postprandial changes in leptin concentrations of cerebrospinal fluid in dogs during development of obesity. Am. J. Vet . Res., 67:2006-2011.

7 ) Jeusette, I., Daminet, S., Nguyen, P., Shibata, H., Saito, M., Honjoh, T., Istasse, L. and Diez, M. 2006. Effect of ovariectomy and ad libitum feeding on body composition , thyroid status, ghrelin and leptin plasma concentrations in female dogs. J. Anim. Physiol. Anim. Nutr., 90: 12-18.


Publications other than original articles


1 ) Okamatsu , Y. and Saito , M. 2006. The function and differentiation of brown adipose tissue. Saibou, 38: 14-18. (in Japanese)

2 ) Okamatsu, Y. and Saito, M. 2006. Origin and differentiation of brown adipocytes. The Lipid, 17: 157-163. (in Japanese)

3 ) Okamatsu, Y. and Saito, M. 2006. Role of uncoupling protein1in the fat-reducing effect of leptin. Himankenkyu, 12:73-75. (in Japanese)

4 ) Okamatsu , Y. , Omachi , A. and Saito , M. 2006. Brown and white adipocytes : the roles in energy metabolism. Bunshisaibochiryo,  5: 28-34. (in Japanese)

5)  Okamatsu, Y. and Saito, M. 2006. Control of whole body energy metabolism by brown adipose tissue. Clinical Neuroscience, 24:914-916. (in Japanese)



Original Articles


1 ) Ishioka, K., Okumura, M., Sagawa, M., Nakadomo, F., Kimura, K. and Saito, M.  2005. Computed tomographic assessment of body fat in beagles. Vet. Radiol. Ultrasound, 46: 49-53.

2 ) Ishioka, K., Hatai, H., Komabayashi, K., Soliman, M. M., Shibata, H., Honjoh, T., Kimura, K. and Saito, M. 2005. Diurnal variations of serum leptin in dogs : effects of fasting and re-feeding. Vet . J. , 169: 85-90.

3 ) Inokuma, K., Ogura-Okamatsu, Y., Toda, C., Kimura, K., Yamashita, H. and Saito, M. 2005.  Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue. Diabetes, 54: 1385-1391.

4 ) Kontani , Y. , Wang , Y. , Kimura , K . , Inokuma, K., Saito, M., Suzuki, T.,Wang, Z., Sato, Y., Mori, N. and Yamashita, H. 2005. UCP1 deficiency increases susceptibility to diet-induced obesity with age .Aging Cell, 4: 147-155.

5 ) Shibata, H. , Akahane, R. , Honjoh, T. , Asano , M. , Mominoki , K . , Fujii , K . , Suzuki, M., Ohtaishi, N., Ishioka, K., Ahmed, M. M., Solilman, M. M., Kimura, K. and Saito, M. 2005. Seasonal changes in serum leptin of the feral raccoon(Procyon lotor) determined by canine-leptinspecific ELISA. J. Exp. Zool., 303A: 527-533.

6 ) Moore, M.C., Kimura, K., Shibata, H., Honjoh, T., Saito, M., Everett,C.A., Smith, M.S. and Cherrington, A.D. 2005. Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs. Am. J. Physiol. Endocrinol. Metab., 289: E225-E231.

7 ) Kimura, K., Niijima, A., Yoshida, R., Kitamura, T., Kamikawa,A., Furuya, D. T., Kitamura, N., Konno, A. , Nakamoto, H. , Sakane, N., Yoshida, T. and Saito, M. 2005. Proinsulin C-peptide activates vagus efferent output in rats. Peptides, 26: 2547-2553.

8 ) Jeusette, I. C., Detilleux, J., Shibata, H., Saito, M., Honjoh, T., Delobel, A., Istasse, L. and Diez, M. 2005. Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs. Res. Vet. Sci., 79: 169-175.

9 ) Knudson, J.D., Dincer, U.D., Dick, G.M., Shibata, H., Akahane, R., Saito, M. and Tune, J.D. 2005. Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction . Am. J. Physiol. Heart Circ. Physiol., 289: H1038-H1046.

10) Mominoki , K . , Morimatsu , M. , Karjalainen, M., Hohtola, E., Hissa, R. and Saito, M. 2005. Elevated plasma concentrations of haptoglobin in European brown bears during hibernation. Comp. Biochem. Physiol., 142: 472-477.


Publications other than original articles


1 ) Matsushita, Y. and Saito,M. 2005. Obesity and genes. Taiiku no kagaku, 55: 194-198. (in Japanese)

2 ) Inokuma, K., Okamatsu-Ogura, Y. and Saito, M. 2005.  UCP1 is necessary for anti -obesity effect of β3 agonist . Himankenkyu, 11: 188-190. (in Japanese)

3 ) Saito , M. 2005. Studies on the control mechanism of energy metabolism and its relation to obesity. J. Hokkaido Vet. Med. Assoc., 49: 305-307. (in Japanese)

4 ) Kimura, K. 2005. Biological effects of proinsulin C-peptide. Seikagaku, 77: 419-423. (in Japanese)

5 )  Hardie , G. and Saito, M. 2005. AMPactivated protein kinase : signal transduction mechanism and physiological roles. Adiposciences, 2: 404-413. (in Japanese)

6 ) Saito, M. 2005. Dietary control of energy dissipating UCP. Brain techno news, 110: 1-4. (in Japanese)

7 ) Saito, M. 2005.  Obesity, lifestyle-related diseases and dietary factors. Brain techno news, 110: 5-9. (in Japanese)



Original Articles


1 ) Makondo, K., Kimura, K., Kitamura, T., Yamaji, D., Bae, D, J., Shibata, H., Saito, M. 2004. Hepatocyte growth factor/scatter factor suppresses TNF-α-induced E-selectin expression in human umbilical vein endothelial cells. Biochim. Biophys. Acta, 1644: 9-15.


2 ) Nakamoto, H., Sakane, N., Kimura, K., Yoshida, T., Mochizuki, S., Ogasawara, Y., Kajiya, F. 2004. Synergistic effects of C-Peptide and insulin on coronary flow in early diabetic rats.Metabolism, 53: 335-339.


3 ) Yamaji, D., Kitamura, H., Kimura, K., Matsushita, Y., Okada, H., Shiina, T., Morimatsu, M., Saito, M. 2004. Cloning of bovine MAIL and its mRNA expression in white blood cells of Holstein cows. Vet. Immnol.

Immunopath., 98: 175-184.


4 ) Soliman, M., Okamoto, S., Kitamura, H., Kushibiki, S., Kimura, K., Saito, M. 2004. Adrenocortical responses to tumor necrosis factor-α and interferon-γ in cattle. Jpn. J. Vet. Res., 52: 95-99.


5 ) Rung-ruangkijkrai, T., Fujikura, D., Kitamura, H., Saito, M., Iwanaga, T. 2004. The expression of src-suppressed C kinase substrate(SSeCKS) and uptake of exogenous particles in endothelial and reticular cells. Arch. Histol. Cytol., 67: 135-147.


6 ) Shaban, Z., El-Shazly, S., Abdelhady, S., Fattouh, I., Muzandu, K., Ishizuka, M., Kimura, K., Kazusaka, A., Fujita, S. 2004. Down regulation of hepatic PPARα function by AhR ligand. J. Vet. Med. Sci., 66: 1377-1386.


7 ) Shaban, Z., El-Shazly, S., Ishizuka, M., Kimura, K., Kazusaka, A., Fujita, S. 2004. PPARα-dependent modulation of hepatic CYP1A by clofibric acid in rats. Arch. Toxicol, 78: 496-507.


8 ) Ohashi, A., Matsushita, Y., Shibata, H., Kimura, K., Miyashita, K., Saito, M. 2004. Conjugated linoleic acid deteriorates insulin resistance in obese/diabetic mice in association with decreased production of adiponectin and leptin. J. Nutr. Sci. Vitaminol., 50: 416-421.


Publications other than original articles


1 ) Omachi, A., Ishioka, K., Shibata, H., Honjoh, T., Kimura, K., Saito, M. 2004. Canine adiponectin: measurement of its serem/plasma concentration by ELISA and effects of obesity. Vet. Biochem., 41: 31-37. (in Japanese)


2 ) Inokuma, K., Okamatsu-Ogura, Y., Saito, M. 2004. The mechanism of energy expenditure by uncoupling protein 1 (UCP1) and its physiological role..Gendaiiryo, 36: 33-38. (in Japanese)


3 ) Matsushita, Y., Noda, S., Irie, Y., Kimura, K., Saito, M. 2004. A search for brown adipocyte-specific genes. Himankenkyu, 10: 99-100. (in Japanese)


4 ) Saito, M. 2004. Molecular mechanism of fat energy dissipation and dietary factors. J. Jpn. Soc. Metab. Clin. Nutr., 7: 229-235. (in Japanese)


5 ) Omachi, A., Saito, M. 2004. Isolation and cell culture of brown adipocytes. Adiposciences, 1: 443-447. (in Japanese)


6 ) Okamatsu-Ogura, Y., Inokuma, K. 2004. The role of uncoupling protein 1 in energy consumption. Diabetes and metabolic syndrome, 406-408. (in Japanese)



Original Articles


1 ) Kitamura, H., Matsushita, Y., Iwanaga, T., Mori, K., Kanehira, K., Fujikura, D.,Morimatsu, M., Saito, M.2003. Bacterial lipopolysaccharide-induced expression of the IkB protein MAIL in B-lymphocytes and macrophages. Arch. Histol. Cytol.,66:53-62.


2 ) Makondo, K., Kimura, K., Kitamura, T., Yamaji, D., Saito, M.2003. Hepatocyte growth factor transduces different intracellular signals in aortic and umbilical venous endothelial cells. Jpn. J. Vet. Res., 51:105-112.


3 ) Makondo, K., Kimura, K., Kitamura., N., Kitamura, T., Yamaji, D., Jung B. D.,Saito, M.2003. Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca2- and phosphoinositide 3-kinase/Akt-dependent phosphorylation in aortic endothelial cells.Biochem. J., 374:63-69.


4 ) Shibata, H., Sasaki, N., Honjoh, T., Ohishi, I.,Takiguchi, M., Ishioka, K., Ahmed, M., Soliman, M., Kimura, K., Saito, M.2003. Feline Leptin : Immunogenic and biological activities of the recombinant protein, and its measurement by ELISA. J. Vet. Med. Sci., 65:207-1211.


5 ) Kitamura, T., Kimura, K., Makondo, K., Furuya, D T., Suzuki, M., Yoshida, T., Saito, M. 2003. Proinsulin C-peptide increases nitric oxide production by enhancing mitogen-activated protein kinase-dependent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats. Diabetologia, 46:1698-1705.


Publications other than original articles


1 ) Kimura, K., Ishioka, K., Sasaki, N., Shibata, H., Honjoh, T., Ohishi, I., Saito, M.2003. Canine and feline leptin: a biomarker for quantitative assessment of obesity. J. Vet. Med., 56:43-46. (in Japanese)


2 ) Saito, M. 2003. Mechanism of energy expenditure regulation in brown adipose tissue and obesity. J. Jpn. Soc. Nutr. Food. Sci., 56:33-39. (in Japanese)


3 ) Ohashi, A. and Saito, M.2003. Uncoupling protein and energy metabolism. Nippon Rinsyo, 61:271-276. (in Japanese)


4 ) Ohashi, A., Saito, M. 2003. Conjugated linoleic acid inducse body fat loss, insulin resistance and fatty liver. Himan Kenkyu, 9:128-135. (in Japanese)


5 ) Kimura, K., Kitamura, T., Saito, M.2003. Proinsulin C-peptide:cellular signaling and action. Vet. Biochem., 40:9-16. (in Japanese)


6 ) Saito, M. 2003. Crosstalk between brain and nutrition. Nutrition, Brain and Behavior. pp1-22. Saito, M., Torii, K. and Aoyama, Y. eds., Kenpakusya, Tokyo. (in Japanese)


7 ) Saito, M. 2003. Regulation of energy expenditure and nutrition. Nutrition, Brain and Behavior. pp157-182. Saito, M., Torii, K. and Aoyama, Y. eds., Kenpakusya, Tokyo. (in Japanese)


8 ) Saito, M.2003. Roles of UCP in the regulation of energy expenditure. 124th Nihon Igakukai Symposium, 62-70. (in Japanese)



Original Articles


1 ) Sagawa, M. M., Nakadomo, F., Honjoh, T., Ishioka, K. and Saito, M. 2002. Correlation between plasma leptin concentration and body fat content in dogs. Am. J. Vet. Res., 63: 7-10.


2 ) Ishioka, K., Kanehira, K., Sasaki, N., Kitamura, H., Kimura, K. and Saito, M. 2002. Canine mitochondrial uncoupling proteins: structure and mRNA expression of three isoforms in adult beagles. Comp. Biochem. Physiol.

B, 131: 483-489.


3 ) Kitamura, H., Okita, K., Fujikura, D., Mori, K., Iwanaga, T. and Saito, M. 2002. Induction of src-suppressed C kinase substrate (SSeCKS) in vascular endothelial cells by bacterial lipopolysaccharide. J. Histochem. Cytochem., 50: 245-255.


4 ) Ishioka, K., Soliman, M., Sagawa, M., Nakadomo, F., Shibata, H., Honjoh, T., Hashimoto, A., Kitamura, H., Kimura, K. and Saito, M. 2002. Experimental and clinical studies on plasma leptin in obese dogs. J. Vet. Med. Sci., 64: 349-353.


5 ) Takahashi, N., Kawada, T., Goto, T., Yamamoto, T., Taimatsu, A., Matsui, N., Kimura, K., Saito, M., Hosokawa, M., Miyashita, K. and Fushiki, T. 2002. Dual action of isoprenols from herbal medicines on both PPARγ and PPARα in 3T3-L1 adiopocytes and HepG2 hepatocytes. FEBS Lett., 514: 315-322.


6 ) Kitamura, H., Kanehira, K., Shiina, T., Morimatsu, M., Jung, B. D., Akashi, S. and Saito, M. 2002. Bacterial lipopolysaccharide induces mRNA expression of an IκB MAIL through toll-like receptor 4. J. Vet. Med. Sci., 64: 419-422.


7 ) Kitamura, T., Kimura, K., Jung, B. D., Makondo, K., Sakane, N., Yoshida, T. and Saito, M. 2002. Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells. Biochem. J., 366: 737-744.


8 ) Soliman, M., Ishioka, K., Yoshida, R., Komabayashi, K., Hatai, H., Matsui, Y., Hirai, T., Katagiri, S., Takahashi, Y., Kawakita, Y., Abe, H., Kitamura, H., Kimura, K. and Saito, M. 2002. Serum leptin levels during the periparturient period in cows. J. Vet. Med. Sci., 64: 1053-1056.


9 ) Soliman, M., Ishioka, K., Kimura, K. Kushibiki, S. and Saito, M. 2002. Plasma leptin responses to lipopolysaaccharide and tumor necrosis factor α in cows. Jpn. J. Vet. Res., 50: 107-114.


10) Takada, K., Kitamura, H., Takiguchi, M., Saito, M. and Hashimoto, A. 2002. Cloning of canine 21-hydroxylase gene and its polymorphic analysis as a candidate gene for congenital adrenal hyperplasia-like syndrome in Pomeranians. Res. Vet. Sci., 73: 159-163.


11) Ishioka, K., Soliman, M. M., Okumura, M., Sagawa, M., Shibata, H., Honjoh, T., Kitamura, H., Kimura, K. and Saito, M. 2002. Effects of fish oil feeding on obesity and UCP expression in dogs. Vet. Biochem., 39: 31-38. (in Japanese with English summary)


12) Ishioka, K., Soliman, M. M., Honjoh, T., Shibata, H., Kimura, K. and Saito, M. 2002. Dexamethasone increases serum leptin concentration. Vet. J., 164: 295-297.


13) Nagase, I. and Saito, M. 2002. Up-regulation of UCP by long-chain fatty acids in L6 myotubes. Himankenkyu (J. Jpn. Soc. Study Obesity), 8: 75-79. (in Japanese)


14) Fujimoto, W., Suzuki, M., Kimura, K. and Iwanaga, T. 2002. Cellular expression of the gut chitinase in the stomach of frogs Xenopus laevis and Rana catesbeiana. Biomed. Res., 23: 91-99.


Publications other than original articles


1 ) Saito, M. 2002. Molecular mechanism of energy expenditure. Bio Clinica, 17: 139-143. (in Japanese)


2 ) Ohashi, A. and Saito, M. 2002. Energy metabolism and uncoupling protein. Medical Science Digest, 28: 487-491. (in Japanese)


3 ) Ishioka, K., Sagawa, M., Morooka, T., Niiyama, M. and Saito, M. 2002. Evaluation of obesity. SA Medicine, 4: 12-20. (in Japanese)


4 ) Noda, S., Irie, Y., Kimura, K. and Saito, M. 2002. Energy metabolism and brown adipocyte. Pharma Medica, 20: 61-67. (in Japanese)



Original Articles


1 ) Morooka, T., Niiyama, M., Uchida, E., Uemura, M., Miyoshi, K. and Saito, M. 2001. Measurement of the back fat layer in beagles for estimation of obesity using two-dimensional ultrasonography. J. Small Anim. Pract. 42: 56-59.


2 ) Iwai, M., Cui, T. X., Kitamura, H., Saito, M. and Shimazu, T. 2001. Increased secretion of tumor necrosis factor and interleukin-6 from isolated, perfused liver of rats after partial hepatectomy. Cytokine 13: 60-64.


3 ) Murase, T., Kondo, H., Hase, T., Tokimitsu, I. and Saito, M. 2001. Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates. Biochim. Biophys. Acta 1530: 15-22.


4 ) Nakamura, Y., Nagase, I., Asano, A., Sasaki, N., Yoshida, T., Umekawa, T., Sakane, N. and Saito, M. 2001. β3-Adrenergic agonist up-regulates uncoupling proteins 2 and 3 in skeletal muscle of the mouse. J. Vet. Med. Sci. 63: 309-314.


5 ) Asano, A., Irie, Y. and Saito, M. 2001. Isoform-specific regulation of vascular endothelial growth factor (VEGF) family mRNA expression in cultured mouse brown adipocytes. Mol. Cell. Endocrinol. 174: 71-76.


6 ) Kitamura, T., Kimura, K., Jung, B. D., Makondo, K., Okamoto, S., Canyas, X., Sakane, N., Yoshida, T. and Saito, M. 2001. Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein. Biochem. J. 355: 123-129.


7 ) Ishikawa, I., Kitamura, H., Kimura, K. and Saito, M. 2001. Brain interleukin-1 is involved in blood interleukin-6 response to immobilization stress in rats. Jpn. J. Vet. Res. 49: 19-25.


8 ) Shiroshita, N., Musashi, M., Sakurada, K., Kimura, K., Tsuda, Y., Ota, S., Iwasaki, H., Miyazaki, T., Kato, T., Miyazaki, H., Shimosaka, A. and Asaka, M. 2001. Involvement of protein kinase C-ε in signal transduction of thrombopoietin in enhancement of interleukin-3-dependent proliferation of primitive hematopoietic progenitors. J. Pharmacol. Exp. Ther. 297: 868-875.


9 ) Nagase, I., Yoshida, T. and Saito, M. 2001. Up-reguration of uncoupling proteins by β-adrenergic stimulation in L6 myotubes. FEBS Lett. 494: 175-180.


10) Okamoto, S., Kimura, K. and Saito, M. 2001. Anorectic effect of leptin is mediated by hypothalamic corticotropin-releasing hormone, but not by urocortin, in rats. Neurosci. Lett. 307: 179-182.


11) Sasaki, N., Shibata, H., Honjoh, T, Kimura, K., Saito, M. and Ohishi, I. 2001. cDNA cloning of feline leptin and its mRNA expression in adipose tissue. J. Vet. Med. Sci. 63: 1115-1120.


12) Soliman, M., Abdelhady, S., Fattouh, I., Ishioka, K., Kitamura, H., Kimura, K. and Saito, M. 2001. No alteration in serum leptin during acute endotoxemia in sheep. J. Vet. Med. Sci. 63: 1143-1145.


13) Abe, H., Kawakita, Y., Kodate, K. and Saito, M. 2001. Postnatal development of glucose transporter proteins in bovine skeletal muscle and adipose tissue. J. Vet. Med. Sci. 63: 1071-1075.


14) Shiina, T., Morimatsu, M., Kitamura, H., Ito, T., Kidou, S., Matsubara, K., Matsuda, Y., Saito, M. and Syuto, B. 2001. Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene. Immunogenetics 53: 649-655.


15) Konno, A., Ahn, J.-S., Kitamura, H., Hamilton, M. J., Gebe, J. A., Aruffo, A. and Davis, W. C. 2001. Tissue distribution of CD6 and CD6 ligand in cattle: expression of the CD6 ligand (CD166) in the autonomic nervous system of cattle and the human. J. Leukoc. Biol. 69: 944-950.


16) Ishioka, K., Shibata, H., Honjo, T., Sagawa, M., Nakadomo, F., Kimura, K. and Saito, M. 2001. Enzyme-linked immunosorbent assay of canine leptin and increased serum concentrations in obese beagles. Vet. Biochem. 38: 35-41.(in Japanese with English summary)


Publications other than original articles


1 ) Kitamura, H., Jung, B. D., Kimura, K. and Saito, M. 2001. Interaction of immune cytokines and the sympathetic nervous system: mechanisms of hepaic cytokine induction in stress situations. Auton Nerv. Sys. 38: 234-241. (in Japanese)


2 ) Irie, Y. and Saito, M. 2001. Ectopic expression of UCP1 in white adipose tissue. Himankenkyu 1: 63-65. (in Japanese)


3 ) Saito, M. 2001. UCP family and lipid energy metabolism. Therap. Res. 22: 1200-1204. (in Japanese)


4 ) Ishioka, K. and Saito, M. 2001. Obesity in dogs: novel methods for diagnosis. SA Medicine 3: pp55-64. (in Japanese)


5 ) Saito, M. and Ohashi, A. 2001. Mitochondrial uncoupling protein as a target of pharmacotherapy for obesity. Folia Pharmacol. Jpn. 118: 327-333. (in Japanese)


6 ) Ohashi, A. and Saito, M. 2001. Uncoupling protein, obesity and glucose metabolism. Diabetes J. 29: 103-110. (in Japanese)



Original Articles


1 ) Okamoto, S., Irie, Y., Ishikawa, I., Kimura, K. and Saito, M. 2000. Central leptin suppresses splenic lymphocyte functions through activation of the corticotropin-releasing hormone-sympathetic nervous system. Brain Res. 855 : 192-197.


2 ) Iwase, M., Kimura, K., Komagome, R., Sasaki, N., Ishioka, K., Honjoh, T. and Saito, M. 2000. Sandwich enzyme-linked immunorbent assay of canine leptin. J. Vet. Med. Sci. 62 : 207-209.


3 ) Jung, B. D., Kimura, K., Kitamura, H., Makondo, K., Kanehira, K. and Saito, M. 2000. Sympathetic activation of hepatic and splenic IL-1β mRNA expression during oscillation stress in the rat. J. Vet. Med. Sci. 62 : 409-413.


4 ) Jung, B. D., Kimura, K., Kitamura, H., Makondo, K., Okita, K., Kawasaki, M. and Saito, M. 2000. Norepinephrine stimulates interleukin-6 mRNA expression in primary cultured rat hepatocytes. J. Biochem. 127 : 205-209.


5 ) Iwase, M., Kimura, K., Sasaki, N., Komagome, R., Ishioka, K., Morimatsu, M., Murakami, T. and Saito, M. 2000. Canine leptin: cDNA cloning, expression and activity of recombinant protein. Res. Vet. Sci. 68 : 109-114


6 ) Soliman, M. M., Okamoto, S., Kitamura, H., Kimura, K. and Saito, M. 2000. Neuroendocrine and metabolic responses to recombinant interferon-γ in cattles. Proceeding of the international veterinary cytokine and vaccine conference. : 294-297.


7 ) Kimura, K., Sasaki, N., Asano, A., Mizukami, J., Kayahashi, S., Kawada, T., Fushiki, T., Morimatsu, M., Yoshida, T. and Saito, M. 2000. Mutated human β3-adrenergic receptor (Trp64Arg) lowers the response to β3-adrenergic agonists in transfected 3T3-L1 preadipocytes. Horm. Metab. Res. 36 : 91-96.


8 ) Komagome, R., Kimura, K. and Saito, M. 2000. Postnatal changes in Rho and Rho-related proteins in the mouse brain. Jpn. J. Vet. Res. 47 : 127-133.


9 ) Kitamura, H., Kanehira, K., Okita, K., Morimatsu, M. and Saito, M. 2000. MAIL, a novel nuclear IκB protein that potentiates LPS-induced IL-6 protein. FEBS Lett. 485 : 53-56.


10) Okamoto, S., Kimura, K., Kitamura, T., Canas, X., Yoshida, T. and Saito, M. 2000. Proinsulin C peptide obviates sympathetically mediated suppression of splenic lymphocyte activity in rats. Diabetologia 43 : 1512-1517.


11) Jung, B. D., Kimura, K., Kitamura, H. and Saito, M. 2000. Sympathetic regulation of hepatic interleukin expression during non-invasive stress. Animal Biochemistry 36 (2) : 21-28. (in Japanese with English summary)


12) Ishioka, K., Kanehira, K., Kitamura, H., Sasaki, N., Kimura, K. and Saito, M. 2000. Canine uncoupling proteins: cDNA cloning and tissue distribution. Veterinary Biochemistry 37 (2) : 57-64. (in Japanese with English summary)


Publications other than original articles


1 ) Saito, M. 2000. An obsity-related gene UCP. Yakuji-nippo 9237 : 22. (in Japanese)


2 ) Kimura, K. 2000. Role of prostanoid in hepatic glycogenolysis. Zoukikanryu-jikken-kouza : 39-42. (in Japanese)


3 ) Nagase, I. and Saito, M. 2000. Energy metabolism and obesity. The Lipid 11 : 468-473. (in Japanese)


4 ) Saito, M. 2000. Role of UCP in energy exoenditure. Diabetes Frontier 11 : 812-816. (in Japanese).


5 ) Kitamura, H., Terao, A, and Saito, M. 2000. Neuroregulatory actions of inflammatory cytokines. Handbook of biomimetics(Nagata, Y. eds.) NTS Tokyo : pp752-757. (in Japanese).


6 ) Kitamura, H., Morimatsu, M. and Saito, M. 2000. Stress and immunity : an general view of interactions between nervous endocrine, and immune systems. Karada-no-naka-kara-stress-wo-miru. (Nihon-hikaku-naibunnpitsu-gakkai eds.) Tokyo : pp93-121. (in Japanese)



Original Articles


1 ) Irie, Y., Asano, A., Canas, X., Nikami, H., Aizawa, S. and Saito, M. 1999. Immortal brown adipocytes from p53-knockout mice Differentiation and expression of uncoupling proteins. Biochem. Biophys. Res. Commun., 255 : 221-225.


2 ) Asano,A., Kimura, K. and Saito, M. 1999. Cold-induced mRNA expression of angiogenic factors in rat brown adipose tissue. J Vet. Med. Sci.. 61 : 403-409.


3 ) Shimamoto, Y., Kitamura, H., Iwai, M., Saito, M., Kazusaka, A. and Fujita, S. 1999. Mechanism of decrease in levels of hepatic P450 isozymes induced by intracerebral endotoxin : independence from sympathetic nervous and adrenocortical systems. Arch Toxicol ., 73 : 41-49.


4 ) Kltamura, P. H.,Yanase, H., Kitamura, H. and lwanaga, T. 1999. Unique localization of protein gene product 9. 5 in type B synoviocyies in the joints of the horse. J Histochem. Cytochem. , 47 : 343-351.


5 ) Shimamoto, Y., Tasaki, T., Kitamura, H., Hirose, K., Kazusaka, A. and Fujita, S. 1999. Decrease in hepatic CYP 2 C11 mRNA and increase in heme oxygenase activity after intracerebroventricular injection of bacterial endotoxin. J Vet. Med. Sci., 61 : 609-613.


6 ) White, B. H., Kimura, K. and Sidhu, A. 1999. Inhibition of hormonally induced inositol triphosphate production in transfected GH 4 C I cells : A novel role for the D- 5 subtype of the dopamine receptor. Neuroendocrinology , 69 : 209-216.


7 ) Sidhu, A., Olde, B., Humblot, N., Kimura, K. and Gardner, N. 1999. Regulation of human D- I dopamine receptor function and gene expression in SK-N-MC neuro-blastoma cells. Neuroscience, 91 : 537-547.


8 ) Komagome, R., Shuto, B., Moriishi, K., Kimura, K. and Saito, M. 1999. Neuronal and glial differentiation of neuroblastoma and glioma cell lines by Rho inhibitory exoenzyme C3. Neuropathology. 19 : 288-293.


9 ) Kimura, K., Jung, B. D., Kanehira, K., Irie, Y., Canas, X. and Saito, M. 1999. Induction of uncoupling protein (UCP) 2 in primary cultured hepatocytes. FEBS Lett . , 457 : 75-79.


10) Yoshida, T., Sakane, N., Umekawa, T., Kogure, A., Kondo, M., Kumamoto, K., Kagawa, T., Nagase, I. and Saito, M. 1999. Nicotine induces uncoupling protein I in white adipose tissue of obese mice. Int. J Obesity, 23 : 570-575.


11) Nagase, I., Yoshida, S., Canas, X., Irie, Y., Kimura, K., Yoshida, T. and Saito, M. 1999. Up-regulation of uncoupling protein 3 by thyroid hormone, peroxisome proliferator-activated receptor ligands and 9 -cis retinoic acid in L 6 myotubes. FEBS Lett., 461 : 319-322.


Publications other than original articles


1 ) Irie,Y. and Saito, M. 1999. Brown adipocytes and UCP family. Molecular Medicine, 36 : 264-270 (in Japanese) .


2 ) Kitamura, H. and Saito, M. 1999. Molecuar and cellular biology of brain. ( 2 ) Isolation of novel genes using the RAP-PCR technique. Neuroscience Experimental Manual. (K. Honma. and K. Fukushima. eds. ) Hokkaido Univ. Sapporo : 61-66 (in Japanese) .


3 ) Nagase, I. and Saito, M. 1999. UCP3. Himan-Kenkyu, 5 : 48-50 (in Japanese).


4 ) Irie, Y. and Saito, M. 1999. Mitochondorial uncoupling protein family and energy metabolism, obesity. Kagaku-to-seibutsu, 37 : 514-520 (in Japanese) .


5 ) Saito, M. 1999. Himan UPDATE, Uncoupling protein UCP. Mebio. 16 Supplement. Multiple Risk Factor Syndrome, 3 : 122-128 (in Japanese).



Original Articles


1 ) Kimura,K., Moriyama,M., Nishisako,M., Kannan,Y., Shiota,M., Sakurada,K., Musashi,M. and Sugano,T. 1998. Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. J. Biochem., 123 : 142-149.


2 ) Yoshida,T., Umekawa,T., Kumamoto,K., Sakane,N., Kogure,A., Kondo,M., Wakabayashi,Y., Kawada,T., Nagase,I. and Saito,M. 1998. β3-adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers. Am. J. Physiol., 274 ( Endocrinol. Metab. 37) : E469-E475.


3 ) Sasaki,N., Uchida,E., Niiyama,M., Yoshida,T. and Saito,M. 1998. Anti-obesity effects of selective agonists to the β3-adrenergic receptor in dogs. 1. The presence of canine β3-adrenergic receptor and in vivo lipomobilization by Its agonists. J. Vet. Med. Sci., 60 (4) : 459-463.


4 ) Sasaki,N., Uchida,E., Niiyama,M., Yoshida,T. and Saito,M. 1998. Anti-obesity effects of selective agonists to the β3-adrenergic receptor in dogs. 2. Recruitment of adiposity after chronic treatment with a β3-adrenergic agonist. J. Vet. Med. Sci., 60 (4) : 465-469.


5 ) Kitamura,H., Okamoto,S., Shimamoto,Y., Morimatsu,M., Terao,A. and Saito,M. 1998. Central IL-1 differentially regulates peripheral IL-6 and TNF synthesis. Cell. Mol. Life Sci., 54 : 282-287.


6 ) Kimura,K., Moriyama,M., Nishisako,M., Kannan,Y., Shiota,M. and Sugano,T. 1998. Endotoxin modulates arachidonic acid-induced glycogenolysis in the perfused rat liver. Horm. Metab. Res., 30 : 178-181.


7 ) Abe,H., Kawakita,Y., Miyashige,T., Morimatsu,M. and Saito,M. 1998. Comparison of amino acid sequence of the C-terminal domain of insulin-responsive glucose transporter (GLUT4) in livestock mammals. J. Vet. Med. Sci., 60 (6) : 769-771.


8 ) Sidhu,A., Kimura,K., Uh,M., White,B.H., and Patel,S. 1998. Multipule coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz. J. Neurochem., 70 : 2459-2467.


9 ) Terao,A., Matsumura,H. and Saito,M. 1998. Interleukin-1 induces slow-wave sleep at the prostaglandin D2-sensitive sleep-promoting zone in the rat brain. J. Neurosci., 18 (16) : 6599-6607.


10) Shimamoto,Y., Kitamura,H., Hoshi,H., Kazusaka,A., Funae,Y., Imaoka,S., Saito,M. and Fujita,S. 1998. Differential alterations in levels of hepatic microsomal cytochrome P450 isozymes following intracerebroventricular injection of bacterial lipopolysaccharide in rats. Arch. Toxicol., 72 : 492-498.


11) Li,Y-Q., Kobayashi,M., Yuan,L., Wang,J., Matsushita,K., Hamada,J-I., Kimura,K., Yagita,H., Okumura,K. and Hosokawa,M. 1998. Protein kinase C mediates the signal for interferon-γ mRNA expression in cytotoxic T cells after their adhesion to laminin. Immunology, 93 : 455-461.


12) Sakane,N., Yoshida,T., Umekawa,T., Kogure,A., Kondo,M., Nakamura,Y., Sasaki,N., Asano,A. and Saito,M. 1998. Acute and chronic regulation of ob mRNA levels by β3-adrenoceptor agonists in obese yellow KK mice. Endocrine J., 45 (5) : 647-651.


13) Terao,A., Matsumura,H., Yoneda,H. and Saito,M. 1998. Enhancement of slow-wave sleep by tumor necrosis factor-α is mediated by cyclooxygenase-2 in rats. Neuroreport, 9 : 3791-3796.


14) Okamoto,S., Ishikawa,I., Kimura,K. and Saito,M. 1998. Potent suppressive effects of urcortin on splenic lymphocyte activity in rats. Neuroreport, 9 : 4035-4039.


Publications other than original articles


1 ) Saito,M. 1998. Obesity, sympathetic nerve, and adipocyte β3-adrenoceptor. Brain Science, 20 : 41-48 ( in Japanese).


2 ) Saito,M. 1998. Uncoupling protein family : molecular structure and physiological roles. Igakunoayumi, 184 : 578-581 ( in Japanese).


3 ) Okamoto,S.,Ishikawa,I. and Saito,M. 1998. Effects of ginsenosides on the stress-induced immunosuppression. The Ginseng Review, 24 : 108-111 ( in Japanese).


4 ) Saito,M. 1998. Mitochondrial uncoupling protein as a thermogenic molecule. Seikagaku, 70 : 212-216 ( in Japanese).


5 ) Kimura,K. and Saito,M. 1998. Brown adipose tissue and β3-adrenergic receptor. The Lipid, 9 : 253-258 ( in Japanese).


6 ) Asano,A. and Saito,M. 1998. The physiological role of uncoupling protein family. Endocrinology & Diabetology, 6 (3) : 260-266 ( in Japanese).


7 ) Saito,M. 1998. Structure and function of uncoupling protein (UCP). Igakunoayumi, 185. 9 : 596-599 ( in Japanese).


8 ) Saito,M. 1998. Energy metabolism and uncoupling protein. Diabetes Frontier, 9 (4) : 405-414 ( in Japanese).


9 ) Saito,M. 1998. Brown adipocyte and uncoupling protein. Journal of Clinical Sciences, 34 (8) : 1043-48 ( in Japanese).



Original Articles


1 ) Asano, A., Morimatsu, M., Nikami, H., Yoshida, T. & Saito, M. : Adrenergic activation of vascular endothelial growth factor mRNA expression in rat brown adipose tissue: implication in cold-induced angiogenesis. Biochem. J. 328: 179-183, 1997.


2 ) Sharan, S.K., Morimatsu, M., Albrecht, U., Lim, D.-S., Regel, E., Dinh, C., Sands, A., Eichele, G., Hasty, P. & Bradley, A.: Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca 2. Nature 386: 804-810, 1997.


3 ) Kitamura, H., Konno, A., Morimatsu, M., Jung, B.-D., Kimura, K., & Saito, M.: Immobilization stress increases hepatic IL-6 expression in mice. Biochem. Biophys. Res. Commun.238: 707-711, 1997.


4 ) Abe, H., Morimatsu, M., Nikami, H., Miyasghige, T. & Saito, M.: Molecular cloning and mRNA expression of the bovine insulin-responsive glucose transporter (GLUT 4). J. Anim. Sci. 75: 182-188, 1997.


5 ) Umekawa, T., Yoshida, T., Sakane, N., Saito, M., Kumamoto, K. & Kondo, M.: Anti-obesity and anti-diabetic effects of CL316,243, a highly specific b3-adrenoceptor agonist, in Otsuka Long-Evans tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur. J. Endocrinol. 136: 429-437, 1997.


6 ) Sidhu, A., & Kimura, K.: A novel regulation of expression of the a-subunit of the G stimulatory protein by dopamine via D1 dopamine receptors. J. Neurochem. 68: 187-194, 1997.


7 ) Sela, S., White, B.H., Uh, M., Kimura, K., Patel, S. & Sidhu, A.: Dysfunctional D1A receptor-G-protein coupling in proximal tubules of spontaneously hypertensive rats is not due to abnormal G-proteins. J. Hypertension. 15: 259-267, 1997.


8 ) Sidhu, A., Uh, M., Sela, S., White, B. H., Kimura, K. & Patel, S.: Molecular and structural differences between rat brain D-1 and renal DA-1 dopamine receptors. Neurosci. Res.29: 1-8, 1997.


Publications other than original articles


1 ) Sasaki, N., Asano, A. & Saito, M.: Obesity and Thermogenesis: UCP as a target molecule. Himan Kenkyu 3:60-62, 1997 (in Japanese).


2 ) Asano, A. & Saito, M.: The characteristics, proliferation and differentiation of brown adipocytes. Gendai Iryo 29: 977-983,1997 (in Japanese).


3 ) Saito, M.: Uncoupling protein family and regulation of energy expenditure. Hissu-Aminosan Kenkyu 150: 12-18, 1997 (in Japanese).


4 ) Sasaki, N., Asano, A. & Saito, M.: Characteristics of brown adipocytes. Saishin Igaku 52: 1093-1100, 1997 (in Japanese).


5. Saito, M.: Function of brown adiptocytes and its regulation. Mebio 14 (11): 22-28, 1997 (in Japanese).



Original articles


1 ) Nikami, H., Shimizu, Y., Sumida, M., Minokoshi, Y.,Yoshida, T., Saito, M. and Shimazu, T. 1996. Expression of ,ァ3-adrenoceptor and stimulation of glucose transport by β3-agonists in brown adipocyte primary culture. J. Biochem., 119: 120-125.


2 ) Saito, M. and Okamoto, S. 1996. Effects of red ginseng on stress-induced immunosuppression. The Ginseng Rev., 21: 7-11 (in Japanese with English summary).


3 ) Sasaki, N., Uchida, E., Niiyama, M. and Saito, M. 1996. Anti-obesity effect of an adipocyte-specific adrenergic receptor agonist in dogs. Anim. Biochem., 33: 13-18 (in Japanese with English summary).


4 ) Kitamura, H., Okamoto, S., Shimamoto, Y., Terao, A., Morimatsu, M. and Saito, M. 1996. Peripheral IL-6 and TNF expression induced by brain IL-1: new aspect of the acute phase response in liver. In: Liver Innervation, pp. 213-219, Shimazu, T., ed., John Libbey & Company Ltd., London.


5 ) Mominoki, K., Morimatsu, M., Hohtola, E., Kaqalainen, M., Hissa, R. and Saito, M. 1996. Seasonal variation of blood haptoglobin level in brown bears. In: Adaptation to the Cotd: Tenth Internationat Hibernation Symposium, pp 367-372, Geiser. F., Hulbert, A. J. and Nicol, S. C., eds., Univ. New England Press, Armidale.


6 ) Asano, A., Nikami, H., Morimatsu, M. and Saito, M. 1996. Vascular endothelial growth factor in brown adipose tissue: role in angiogenesis during tissue growth after cold exposure. ibid, pp. 299-303.


7 ) Moriyama, M., Makiyama, I., Shiota, M., Uesugi, K., Kannan, Y., Ohta, M., Kimura, K. and Sugano, T. 1996. Decreased ureagenesis from alanine, but not from ammonia and glutamme, in the perfused rat liver after partial hepatectomy. Hepatology, 23: 1584-1590.


8 ) Nagase, I., Yoshida, T., Kumamoto, K., Umekawa, T., Sakane, N., Nikami, H., Kawada. T. and Saito, M. 1996. Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic ァ3-adrenergic agonist. J. Clin. Invest., 97: 2898-2904.


9 ) Mominoki, K., Tsurga, H., Morimatsu, M. and Saito, M. 1996. Seasonal variations of blood haptoglobin level of brown bears in Japan. Comp. Biochem. Physiol., 114A: 349-353.


10) Sasaki, N., Uchida, E., Niiyama, M. and Saito, M. 1996. Anti-obesity effect of an adrenergic agonist activating lipid metabolism in dogs. J. Anim. Clin. Res. Found., 5: 1-14 (in Japanese).


11) Kobayashi, M., Nikami, H., Morimatsu, M. and Saito, M. 1996. Expresssion and localization of insulin-regulatable glucose transporter (GLUT 4) in rat brain. Neurosci. Lett., 213: 103-106.


12) Kimura, K., Hamada, M., Moriyama, M., Kannan, Y., Shiota, M., Sakuraba, K., Musashi, M. and Sugano, T. 1996. Phorbol ester, but not endotoxin, desensitizes mannan-induced glycogenolysis in the perfused rat liver. J. Biochem., 120: 488-493.


13) Okamoto, S., Ibaraki,K., Hayashi, S. and Saito, M. 1996. Ventromedial hypothalamus suppresses splenic Iymphocyte activity through sympathetic innervation. Brain Res., 739: 308-313.


Publications other than original articles.


1 ) Sasaki, N. and Saito, M. 1996. Regulation of energy balance and obesity. Diagnosis and Treatment, 84: 987-992 (in Japanese).


2 ) Okamoto, S., Terao, A., Morimatsu, M. and Saito, M. 1996. Suppression of splenic lymphocyte activities by ventromedial hypothalamic stimulation: Role of sympathetic nervous system. In: Discussions on Future Direction in Psychoneuroimmunoiogy and Cancer, pp. 74-77, Sendo, F. and Herberman, R. B., eds., Nishimura Co. Ltd., Nigata.


3 ) Saito, M. and Sasaki, N. 1996. Uncoupling-protein and ァ3-adrenergic receptor in brown adipocyte. Exp. Med., 14: 40-45 (in Japanese).


4 ) Abe, H., Morimatsu, M. and Saito, M. 1996. Glucose metabolism and glucose transporters in cattle. Anim. Biochem., 33: 1-10 (in Japanese).


5 ) Saito, M. 1996. Interaction between immune and neuro-endocrine system. In: Immunology of Animals, pp. 228 235, Onuma, M., Onodera. and Yamanouchi, K., eds., Buneido Shuppan, Tokyo.