＜ 臨床分子生物学教室 ＞
2007
Original Articles
1) Ito, D., Otsuka, Y., Koshino, I. and Inaba, M. 2007. Lumenal localization
in the endoplasmic reticulum of the C-terminal tail of an AE1 mutant responsible
for hereditary spherocytosis in cattle. Jpn. J. Vet. Res., 54: 191-197.
2) Chung, J. S., Sato, K., Dougherty, I. I., Cruz, P. D., Jr. and Ariizumi,
K. 2007. DC-HIL is a negative regulator of T lymphocyte activation. Blood,
109: 4320-4327.
3) Konno, A., Takiguchi, M., Takada, K., Usami, T., Azumi, K., Kubota,
H., Inaba, M., Saegusa, J. and Kon, Y. 2007. Identification of a quantitative
trait locus regulating B cell-dominant infiltration into autoimmune sialitis
lesions of the IQI mouse model of primary Sjogren’s syndrome. Immunogenetics,
59: 853-859.
4) Sato, K., Otsuka, Y., Arashiki, N., Komatsu, T., Chen-Chi, W., Tamahara,
S. and Inaba, M. 2008. Identification of genes for two major sialoglycoproteins,
glycophorin A and glycophorin C in canine red cell membranes. Jpn. J. Vet.
Res., 55: 103-114.
Publication other than original articles
1) Sato, K., Inaba, M. and Ariizumi, K. 2007. Molecular basis of innate immune responses by recognition of fungi by dendritic cell C-type lectin dectin-2. Veterinary Biochemistry, 44: 15-25.
2006
Original Articles
１）Ito, D., Koshino, I., Arashiki, N., Adachi, H., Tomihari, M., Tamahara, S., Kurogi, K., Amano, T., Ono, K. and Inaba, M．２００６． Ubiquitylation-independent ER-associated degradation of an AE１mutant associated with dominant hereditary spherocytosis in cattle. J. Cell Sci., １１９：３６０２‐ ３６１２．
２）Ohta, H., Adachi, H., Takiguchi, M. and Inaba, M．２００６．Restricted localization of claudin‐１６ at the tight junction in the thick ascending limb of Henle’s loop together with claudins３，４，and１０in bovine nephrons. J. Vet. Med. Sci.,６８：４５３‐４６３．
３）Kageyama, S., Hirayama, H., Moriyasu, S., Inaba, M., Ito, D., Ohta, H., Sawai, K., Minamihashi, A. and Onoe, S．２００６．Genetic diagnosis of band３deficiency and sexing in bovine preimplantation embryos. J. Vet. Med. Sci.,６８：３１９‐３２３．
４）Ohta, H., Adachi, H. and Inaba, M．２００６． Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys. J. Vet. Med. Sci.,６８：１４９‐１５５．
５）Sato, K., Shikano, S., Xia, G., Takao, J., Chung, J. S., Cruz, P. D. Jr., Xie, X. S. and Ari-izumi, K．２００６．Selective expression of vacuolar H＋‐ATPase subunit d２ by particular subsets of dendritic cells among leukocytes. Mol . Immunol . , ４３：１４４３‐ １４５３．
６）Sato, K., Yang, X. L., Yudate, T., Chung, J. S.,Wu, J., Luby-Phelps, K., Kimberly, R. P., Underhill, D., Cruz, P. D. Jr. and Ariizumi, K．２００６．Dectin‐２is a pattern recognition receptor for fungi that couples with the Fc receptor γ chain to induce innate immune responses. J. Biol . Chem. , ２８１： ３８８５４‐３８８６６
2005
Original Articles
１）Takada, K., Takiguchi, M., Konno, A. and Inaba, M．２００５．Autoimmunity against a tissue kallikrein in IQI/Jic mice, a model for Sjogren’s syndrome. J. Biol . Chem. ， ２８０：３９８２‐３９８８
２）Takiguchi, M. and Inaba, M．２００５．Diagnostic ultrasound of polypoid cystis in dogs. J. Vet. Med. Sci.，６７：５７‐６１
３）Takada, K., Takiguchi, M. and Inaba, M． ２００５．Different effects on the inflammatory lesions in lacrimal and salivary glands after neonatal thymectomy in IQI/ Jic mice, a model for Sjogren’s syndrome. J. Vet. Med. Sci.，６７：７５５‐７５７
Publications other than original articles
１）Inaba, M., Ito, D., and Ohta, H．２００５．Dysfunctions in membrane proteins and inherited diseases. Membrane, ３０：３１８‐３２２ （in Japanese with English abstract）
2004
Original Articles
1 ) Takada, K., Takiguchi, M., Konno, A., and Inaba, M., (2004) Spontaneous development of glandular and extraglandular .lesions in aged IQI/Jic mice: a model for primary Sjogren's syndrome. Rheumatology 43, 858-862
2 ) Kim, J.Y., Yokoyama, N., Kumar, S., Inoue, N., Inaba, M., Fujisaki, K., and Sugimoto, C. (2004) Identification od a piroplasm protein of Theileria orientalis that binds to bovine erythrocyte band 3. Mol. Biochem. Parasitol. 237, 193-200
3 ) Hirayama, H., Kageyama, S., Moriyasu, S., Hirano, T., Sugimoto, Y., Kobayashi, N., Inaba, M., Sawai, K., Onoe, S., and Minamihashi, A. (2004) Genetic diagnosis of claudin-16 deficiency and sex determination in bovine preimplantation embryos. J. Reproduct. Develop. 50, 613-618
Publications other than original articles
1 ) Inaba, M. (2004) Physiological roles of band 3: Lessons from molecular bases and pathobiology of inherited disorders in animals. (review article in Japanese) J. Anim. Genet. 31, 25-31
2003
Original Articles
1 ) Konno, A., Takada, K., Saegusa, J. and Takiguchi, M. 2003. Presence of B7-2+ dendritic cells and expression of Th1 cytokines in the early development of sialodacryoadenitis in the IQI/Jic mouse model of primary Sj?gren’s syndrome. Autoimmunity 36 : 247-254.
2 ) Asanuma, T., Matsumoto, Y., Takiguchi, M., Inanami, O., Nakao, M., Nakaya, K., Ito, A., Hashimoto, A. and Kuwabara, M. 2003. Magnetic resonanc imaging and immunoblot analyses in rats with experimentally induced cerebral alveolar echinococcosis. Comp. Med. 53 : 523-530.
3 ) Shibata, H., Sasaki, N., Honjo, T., Ohishi, I., Takiguchi, M., Ishioka, K., Ahmed, M., Soliman, M., Kimura, K. and Saito, M. 2003. Feline Leptin : Immunogenic and biological activities of the recombinant protein, and its measurement by ELISA. J. Vet. Med. Sci. 65 : 1207-1211.
Publications other than original articles
1 ) Inaba, M. 2003. Chapters 1, 3, and 4, In Animal Physiology, Kanno, T. and Taya, K., eds., pp. 1-50, and pp. 64-87, Asakura Shoten, Tokyo.
2 ) Takiguchi, M. 2003. Ultrasonographic diagnosis of gastrointestinal foreign bodies in dogs. Small Animal Clinic 132 : 22-25.
3 ) Takada, K., Kitamura, H., Takiguchi, M., Saito, M., Hashimoto, A. and Inaba, M. 2003. Cloning and polymorphic analysis of canine 21-hydroxyrase gene: a candidate gene for alopecia X in dogs. Veterinary Biochemistry 40 : 21-27.
2002
Original Articles
1 ) Tamahara, S., Inaba, M., Sato, K., Matsuki, N., Hikasa, Y. and Ono, K. 2002. Non-essential roles of cysteine residues in functional expression and redox regulatory pathways for canine glutamate/aspartate transporter based on mutagenic analysis. Biochem. J. 367 : 107-111.
2 ) Takiguchi, M., Watanabe, T., Okada, H., Kudo, T., Yamada, K., Yasuda, J. and Hashimoto, A. 2002. Rhabdomyosarcoma (botryoid sarcoma) of the urinary bladder in a Maltese. J. Small Anim. Pract. 43 : 269-71.
3 ) Matsuki, N., Inaba, M. and Ono, K. 2002. Catabolism of cytoplasmic and intramitochondrial adenine nucleotides in C2C12 skeletal myotube under chemical hypoxia. J. Vet. Med. Sci. 64 : 341-347.
4 ) Ishioka, K., Soliman, M. M., Sagawa, M., Nakadomo, F., Shibata, H., Honjoh, T., Hashimoto, A., Kitamura, H., Kimura, K. and Saito, M. 2002. Experimental and clinical studies on plasma leptin in obese dogs. J. Vet. Med. Sci. 64 : 349-353.
5 ) Boffi, F. M., Ozaki, J., Matsuki, N., Inaba, M., Desmaras, E. and Ono, K. 2002. Effects of chemical ischemia on purine nucleotides, free radical generation, lipids peroxidation and intracellular calcium levels in C2C12 myotube derived from mouse myocytes. J. Vet. Med. Sci. 64 : 483-488.
6 ) Miyoshi, M., Okazaki, K., Takiguchi, M., Kida, H. and Hashimoto, A. 2002. The immediate early gene of canine herpesvirus is transcribed through early and late phases. J. Vet. Med. Sci. 64 : 627-631.
7 ) Bonkobara, B., Thongsong, B., Ohmori, T., Matsuki, N., Inaba, M. and Ono, K. 2002. Effects of epidermal growth factor on placental amino acids uptake in pregnant rats. J. Vet. Med. Sci. 64 : 689-692.
8 ) Thongsong, B., Bonkobara, M., Matsumoto, M., Jang, J., Matsuki, N., Inaba, M. and Ono, K. 2002. Effects of isulin-like growth factor-I on maternal and fetal plasma amino acid levels in pregnant rats. J. Vet. Med. Sci. 64 : 859-861.
9 ) Mochizuki, M., Hashimoto, M., Hajima, T., Takiguchi, M., Hashimoto, A., Une, Y., Roerink, F., Ohshima, T., Parrish, C. R. and Carmichael, L. E. 2002. Virologic and serologic identification of minute virus of canines (canine parvovirus type 1) from dogs in Japan. J. Clin. Microbiol. 40 : 3993-3998.
Publications other than original articles
1 ) Takiguchi, M. 2002. Ultrasonographic appearance of the liver in a dog with hepatocutaneous syndrome. Small Animal Clinic 129 : 29-31.
2001
Original Articles
1 ) Takiguchi, M., Iida, T., Kudo, T. and Hashimoto, A. 2001. Malignant seminoma with systemic metastasis in a dog. J. Small Anim. Pract. 42 : 360-362.
2 ) Watanabe, T., Shinohara, N., Sazawa, A., Takimoto, M., Hashimoto, A., Koyanagi, T. and Kuzumaki, N. 2001. Adenovirus-mediated gene therapy for bladder cancer in an orthotopic model using a dominant negative H-ras mutant. Int. J. Cancer. 92 : 712-717.
3 ) Hashimoto, A., Takiguchi, M., Hirai, K., Kida, H. and Carmichael, L. E. 2001. A serological survey of minute virus of canines (MVC ; Canine parvovirus type-1) in dogs in the Tokai area of Japan. Jpn. J. Vet. Res. 49 : 249-253.
2000
Original Articles
1 ) Takiguchi, M., Murakami, M., Nakagawa, I., Kawaguchi, Y., Rashid, M. M., Chikuma, S., Tosa, N., Hashimoto, A. and Uede, T. 2000. Involvement of CD28/CTLA4-B7 pathway in the development of lymphadenopathy and splenomegaly in MRL/lpr mice. J. Vet. Med. Sci. 62 : 29-36.
2 ) Takiguchi, M., Murakami, M., Nakagawa, I., Hashimoto, A. and Uede, T. 2000. CTLA4IgG gene delivery prevents autoantibody production and lupus nephritis in MRL/lpr mice. Life Sci. 66 : 991-1001.
3 ) Watanabe, T., Shinohara, N., Sazawa, A., Kobayashi, Y., Ogiso, Y., Kimura, T., Takiguchi, M., Yasuda, J., Hashimoto, A., Koyanagi, T. and Kuzumaki, N. 2000. Suppressive effects of dominant negative ras mutant N116Y on transformed phenotypes of human bladder cancer cells. Cancer letters. 149 : 195-202.
4 ) Watanabe, T., Shinohara, N., Moriya, K., Sazawa, A., Kobayashi, Y., Ogiso, Y., Takiguchi, M., Yasuda, J., Koyanagi, T., Kuzumaki, N. and Hashimoto, A. 2000. Siginificance of the Grb2 and son of sevenless (SOS) proteins in human bladder cancer cell lines. IUBMB Life. 49 : 317-320.
5 ) Watanabe, T., Shinohara, N., Sazawa, A., Harabayashi, T., Ogiso, Y., Koyanagi, T., Takiguchi, M., Hashimoto, A., Kuzumaki, N., Yamashita, M., Tanaka, M,. Grossman, H. B. and Benedict, W. F. 2000. An improved intravesical model using human bladder cancer cell lines to optimize gene and other therapies. Cancer gene therapy. 7 : 1575-1580.
6 ) Miyoshi, M., Takiguchi, M., Yasuda, J., Hashimoto, A., Takada, A., Okazaki, K. and Kida, H. 2000. Structure of the infected cell protein 0 gene of canine herpesvirus. Arch. Virol. 145 : 1715-1723.
7 ) Iwata, N., Ochiai, K., Kadosawa, T., Takiguchi, M. and Umemura, T. 2000. Canine extracutaneous mast-cell tumors consisting of connective tissue mast cells. J. Comp. Pathol. 123 : 306-310.
Publications other than original articles
1 ) Takiguchi, M., Murakami, M., Nakagawa, I., Hashimoto, A. and Uede, T. 2000. CTLA4IgG gene delivery prevents autoantibody production and lupus nephritis in MRL/lpr mice. : FASEB J. 14 : Abst. A 1207.
2 ) Amanai, M., Amanai, H., Inoue, Y. and Watanabe, T. 2000. Gastric adenocartinoma in a dog. J. Hokkaido Vet. Med. Assoc. 44 : 100-104 (in Japanese).
3 ) Watanabe, T., Takiguchi, M., Kudo, T. and Hashimoto, A. 2000. Urinary bladder hematoma appeared to be an urinary bladder mass by ultrasound imaging in a dog. J. Hokkaido Vet. Med. Assoc. 44 : 104-106 (in Japanese).
1999
Original articles
1 ) Takiguchi, M., Murakami, M., Nakagawa, I., Yamada, A., Chikuma, S. Kawaguchi Y, Hashimoto, A. and Uede, T. 1999. Blockade of CD28/CTLA 4 -B7 pathway prevented autoantibody-related diseases but not lung disease in MRL/lpr mice. Lab. Invest. 79 : 317-326.
2 ) Miyoshi, M., Takiguchi, M., Yasuda, J., Okazaki, K., Kida, H. and Hashimoto, A. 1999. Structure of immediate early gene of canine herpesvirus. Arch. Virol . 144 : 407-420.
3 ) Miyoshi, M., Ishii, Y., Takiguchi, M., Yasuda, J., Hashimoto, A., Takada, A., Okazaki, K. and Kida, H. 1999. Detection of canine herpesvirus DNA in the ganglionic neurons and the lymph node lymphocyles of latently infected dogs. J Vet. Med. Sci. 61 : 375-379.
4 ) Kitamura, T.,Yasuda, J. and Hashimoto, A. 1999. Acute insulin response to intravenous arginine in nonobese healthy cats. J Vet. Intern. Med . 13 : 549-556.
Publications other than original articles
1 ) Hashimoto, A., Nishikori, T., Watanabe, M., Itakura, C. and Carmichael, L. 1999. Canine parvovirus type- 1 (MVC) : pathomorphological studies on the experimentally infected fetus and MVC-infected cultured cells. Canine Infections Disease : From clinics to Molecular Pathogenesis. Abst. p. 32.
2 ) Yasuda, J., Nakao, K., Kamata, S., Kitamura,Y. and Takiguchi, M. 1999. Development of an ultrasonic washing machine for animals and its clinical application to chronic skin disease of dogs. J Vet. Med . 52 : 801-804. (in Japanese with English summary)
1998
Original articles
1 ) Morita, Y., Takiguchi, M., Yasuda, J., Kitamura, T., Syakalima, M., Eom, K-D., Hashimoto, .1998. Endoscopic ultrasonography of the pancreas in the dog. Vet. Radiology Ultrasound 39: 552-556.
2 ) Morita, Y., Takiguchi, M., Yasuda, J., Eom, K-D.,Hashimoto,A.1998. Endoscopic ultrasonographic findings of the pancreas after pancreatic ligation in the dog. Vet. Radiology Ultrasound 39: 557-562.
3 ) Morita, Y., Takiguchi, M., Yasuda, J., Kitamura, T., Syakalima, M., Hashimoto, A.1998. Endoscopic and transcutaneous ultrasonographic findings and gray-scale histogram analysis in dogs with caerulein-induced pancreatitis. Vet. Quart. 20: 89-92.
4 ) Syakalima, M., Takiguchi, M., Yasuda, J., Morita, Y., Hashimoto, A.1998. Comparison of attenuation and liver-kidney contrast of liver ultrasonographs with histology and biochemistry in dogs with experimentally induced steroid hepatopathy. Vet. Quart. 20: 18-22.
5 ) Ito, A., Sakakibara, Y., Ma, L., Asano, K., Takiguchi, M., Yasuda, J., Hashimoto, A. 1998. Ultrasonographic and serologic studies of experimental cysticercosis in rats infected with Taenia taeniaeformis. Parasite Immunol. 20: 105-110.
6 ) Morita, Y., Takiguchi, M., Yasuda, J., Hashimoto, Y.1998. Preliminary studies on clinical application of endoscopic ultrasonography (EUS) in small animal practice: EUS findings of experimentally-induced cystic lesions in the gastric wall in dogs. Jpn J. Vet. Imag. 10: 37-40. (in apanese with English sammary)
Publication other than original articles
1 ) Syakalima, M., Takiguchi, M., Yasuda, J., Hashimoto, A.1998. The canine alkaline phosphatase: A review of the isoenzymes in serum, analytical methods and their diagnostic application. Jpn. J. Vet. Res. 46: 3-11. (Review)
2 ) Hashimoto, A.1998. Diagnostic ultrasound in small animals. V. Urinary bladder (2)-(4). Jpn. Small Anim. Pract. 17(1): 35-42, 17(5): 55-60, 17(6): 9-14.
3 ) Hashimoto, A.1998. The neutrophili: Function, disorders, and testing. Myelopoiesis and myeloproliferative disorders. In: Raskins R. E. and Meyer, D. J. eds. The Veterinary Clinics of North America: Update on clinical Pathology. pp.27-33, pp.35-49, Gakusosya, Tokyo. (Translation into Japanese)
4 ) Takiguchi, M., 1998. Congenital erythrocyte enzyme deficiencies. von Willebrandis disease in the dog and cat. Molecular tools for the diagnosis of animal diseases. Ibid. pp.19-25, pp.87-102, pp.191-201. (Translation into Japanese)
1997
Original articles
1 ) Takiguchi, M., Yasuda, J., Hashimoto, A., Ochiai, K., Itakura, C. 1997. Esophageal / gastric adenocarcinoma in a dog. J. Am. Anim. Hosp. Assoc. 33 : 42-44.
2 ) Takiguchi, M., Yasuda, J., Ochiai, K., Morita, Y., Hashimoto, A. 1997. Ultraosonographic appearance of orthotopic ureterocele in a dog. Veterinary Radiology & Ultrasound 38: 398-399.
3 ) Syakalima, M., Takiguchi, M., Yasuda, J., Hashimoto, A., 1997. The age dependent levels of serum ALP isoenzoymes and the diagnostic significance of corticosteroid-induced ALP during long term glucocorticoid treatment. J. Vet. Med. Sci. 59 : 905-909.
4 ) Syakalima, M., Takiguchi, M., Yasuda, J., Hashimoto, A. 1997. Separation and quantification of corticosteroid-induced, bone and liver alkaline phosohatase isoenzymes in canine serum. J. Vet. Med. A 44 : 603-610.
5 ) Mashita, T., Yasuda, J., Iijima, M., Takiguchi, M., Yamazaki, T., Hashimoto, A. 1997. Short-term hemodialysis treatment in dogs and cats with total uretic obstruction. Jpn. J. Vet. Res. 45: 59-65.
Publication other than original articles
1 ) Hashimoto, A. 1997. Diagnostic ultrasound in small animals. IV. Kidney (11)-(12). Jpn. Small Animal Pract . 16 : 31-35, 16 : 63-67.
2 ) Hashimoto, A. 1997. Diagnostic ultrasound in small animals. V. Urinary Bladder (1). Jpn. Samll. Animal Pract. 16 : 55- 59.
1996
Original articles
1 ) Ishida, K., Hashimoto. , A., Yasuda, J., Takiguchi, M. and Doi, K. 1996. Ultrasonugrapme exammaIlon of cephaloridine (CER)-induced renal lesions in rabbits. J. ToxicoL PathoL 9: 273-276.
2 ) Yasuda, J., Tanabe, A., Hashimoto, A. and Too, K. 1996. Adenosine deaminase (ADA) activity in tissues and sera from normal and leukaemic cattle. Br. Vet. J. ,152: 485-488.
3 ) Ito, A., Okamoto, M., Kariwa, H., Ishiguro, T., Hashimoto, A. and Nakao, M. 1996. Antibody responses against Echinococcus multilocularis antigens in naturally infected Rattus norvegicus. J. Helminthol., 70: 355-357.
4 ) Lévill, R., Miyabayashi, T., Weisbrode, S. E., Biller, D. S., Takiguchi,M., and Williams, J. F. 1996. Ultrasonographic renal changes associated with phenylbutazone administration in three foals. Can. Vet. J., 37: 235-236.
Publication other than original articles
1 ) Hashimoto, A. 1996. Diagnostic ultrasound in small animals. IV. Kidney (8)-(10). Jpn. Small Animal Pract. 15 (2): 41-46, 15 (4): 63-68, 15 (6): 39-43 (in Japanese).
2 ) Hashimoto, A. 1996. Disease of the locomotive organs; General conception. In: Textbook of Veterinary Internal Medicine, 1st ed., pp. 339-346, Murakami, T. et al. eds., Buneido shuppan, Tokyo (in Japanese).
3 ) Hashimoto, A. 1996. Large intestine. In: Donald, E. Thrall's Textbook of Veterinary Diagnostic Radiology 1st. ed., Chap. 45, pp. 581-592. Suganuma, T. et al. eds., Buneido shuppan, Tokyo (Translation into Japanese).